활용 현황
약효 검색 활용
- 연평균 100건 이상의 산·학·연 과제에 화합물 지원 (연평균 40만개 화합물 활용지원)
- 누적활용 : 1,000여건의 과제에 화합물 제공 (누적 1,000만여개 화합물 제공활용)
- 신약개발연구 활용사례 : KCB 제공 화합물의 활용결과로 도출된 유효화합물을 바탕으로 다양한 국책과제 및 신약개발연구사업 (21C 프론티어 사업, 신약후보물질 발굴사업, 범부처 신약개발사업 등)이 과제화 되어 진행되었습니다. 또한 일부 바이오벤처의 주요사업으로 진행된 경우도 있습니다.
최근 4년간 화합물 활용 현황
활용과제 건수
화합물 분양 횟수
분양 화합물 개수
년도
전체과제
신규과제
전체과제
신규과제
전체과제
신규과제
2019
188건
97건
306회
185회
239,034개
206,980개
2020
223건
105건
414회
254회
479,332개
423,120개
2021
213건
116건
387회
238회
491,985개
340,996개
2022
246건
126건
442회
244회
1,000,752개
245,653개
* 2021년 : 442회에 걸쳐 총 1,000,752개 화합물 분양(평균 4,169개/일)
기관별 화합물 활용 현황
(신규과제건수)
년도
2019
2020
2021
2022
연구기관
37
36
25
33
산업체
17
33
40
49
대학교
43
36
51
44
계
97
105
116
126
연도별 화합물 활용현황
후보물질도출 기여사례
KCB가 제공한 화합물의 활용하여 발견된 유효화합물의 진전연구결과로 도출된 후보물질을 국내외 제약사에 기술이전한 사례를 소개합니다.
활용논문 현황
KCB가 제공한 화합물의 활용결과로 도출된 연구결과를 국내외 전문학술지에 게재된 논문 (KCB에 대한 사사가 포함된 논문)을 소개합니다.
All
2022
2021
2020
2019
2018
2017
2016
2015
2014
2013
2012
2011
2010 ~ 2006
2005 ~
All
| # | Title | Author(s) | Journal | Year | link | Published | 구분 |
|---|---|---|---|---|---|---|---|
| Exploitation of a novel adjuvant for polymyxin B against multidrug-resistant Acinetobacter baumannii | Seon-Yeong Kim, Hwi Won Seo, Min-Seon Park, Chul Min Park, Jinho Seo, Jaerang Rho, Subeen Myung, Kwan Soo Ko, Jun-Seob Kim, Choong-Min Ryu | Journal of Antimicrobial Chemotherapy 2023, dkac445 | 2023 | https://doi.org/10.1093/jac/dkac445 | 연 | ||
| Discovery of 2-Aminoquinolone Acid Derivatives as Potent Inhibitors of SARS-CoV-2 | Young Sup Shin, Jun Young Lee, Sangeun Jeon, Subeen Myung, Hyun June Gong, Seungtaek Kim, Hyoung Rae Kim, Lak Shin Jeong, Chul Min Park | Bioorganic & Medicinal Chemistry Letters | 2023 | https://doi.org/10.1016/j.bmcl.2023.129214 | 연 | ||
| Fasudil alleviates the vascular endothelial dysfunction and several phenotypes of Fabry disease | Jong Bin Choi, Dong-Won Seol, Hyo-Sang Do, Hee-Young Yang, Taek-Min Kim, Youkyeong Gloria Byun, Jae-Min Park, Jinhyuk Choi, Seon Pyo Hong, Won-Suk Chung, Jae Myoung Suh, Gou Young Koh, Beom Hee Lee, Gabbine Wee, Yong-Mahn Han* | Molecular Therapy 2023, 1525-0016(23)00066-7 | 2023 | https://doi.org/10.1016/j.ymthe.2023.02.003 | 2023.06.07 | 학 | |
| Screening of Anti-Adhesion Agents for Pathogenic Escherichia coli O157:H7 by Targeting the GrlA Activator | Sin Young Hong and Byoung Sik Kim* | Journal of Microbiology and Biotechnology 2023, 33(3), 1-10 | 2023 | https://doi.org/10.4014/jmb.2207.07065 | 2023.01.30 | 학 | |
| Tranilast protects pancreatic β-cells from palmitic acid-induced lipotoxicity via FoxO-1 inhibition | Hye-Eun Choi, Dong Young Kim, Mi Jin Choi, Jea Il Kim, Ok-Hee Kim, Jinwook Lee, Eunhui Seo & Hyae Gyeong Cheon* | Scientific Reports 2023, 13, 101 | 2023 | https://doi.org/10.1038/s41598-022-25428-3 | 2023.01.03 | 학 | |
| Identification of a Target Site for Covalent Inhibition of Protein Phosphohistidine Phosphatase 1 | Hyeong Jun Kim,† Hoyoung Jung,† Soyeon Kim, Jeong Kon Seo,* and Jung-Min Kee* | ACS Medicinal Chemistry Letters 2022, 13, 12, 1911–1915 | 2022 | https://doi.org/10.1021/acsmedchemlett.2c00450 | 2022.11.28 | 학 | |
| PredMS: a random forest model for predicting metabolic stability of drug candidates in human liver microsomes | Jae Yong Ryu*, Jeong Hyun Lee, Byung Ho Lee, Jin Sook Song, Sunjoo Ahn and Kwang-Seok Oh* | Bioinformatics 2022, 38(2), 364–368 | 2022 | https://doi.org/10.1093/bioinformatics/btab547 | 2021.09.13 | 연 | |
| A simple protein histidine kinase activity assay for high-throughput inhibitor screening | Donghee Lee, Yunmi Lee, SonHye Shin, SuMin Choi, ShinHyeon Lee, Seonghun Jeong, Soojin Jang*, Jung-Min Kee* | Bioorganic Chemistry 2022, 130, 106232 | 2022 | https://doi.org/10.1016/j.bioorg.2022.106232 | 학 | ||
| Pharmacological inhibition of AIMP2 aggregation attenuates α-synuclein aggregation and toxicity in Parkinson’s disease | Jeong-YongShin, BinaLee, Sangwoo Ham, Ji Hun Kim, Hyojung Kim, Heejeong Kim, Min Gi Jo, Hye Jung Kim, Sang Won Park, Hee-Seok Kweon, Yong Jun Kim, Seung Pil Yun, Yunjong Lee* | Biomedicine & Pharmacotherapy 2022, 156, 113908 | 2022 | https://doi.org/10.1016/j.biopha.2022.113908 | 학 | ||
| 1,3-Dibenzyl-5-Fluorouracil Prevents Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Differentiation | Hyoeun Jeon, Jungeun Yu, Jung Me Hwang, Hye-Won Park, Jiyeon Yu, Zee-Won Lee, Taesoo Kim, and Jaerang Rho* | Immune Network 2022, 26;22(5):e43 | 2022 | https://doi.org/10.4110/in.2022.22.e43 | 2022.09.26 | 학 | |
| DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis | Jee-Heun Kim, So-Yeon Park, So-El Jeon, Jang-Hyun Choi, Choong-Jae Lee, Tae-Young Jang, Hyeon-Ji Yun, Yuno Lee, Pilho Kim, Sang Hee Cho, Ji Shin Lee, Jeong-Seok Nam* | Theranostics 2022, 12(12):5258-5271 | 2022 | https://www.thno.org/v12p5258.htm | 학 | ||
| AI-based prediction of new binding site and virtual screening for the discovery of novel P2X3 receptor antagonists | Koon Mook Kang, Ingoo Lee, Hojung Nam*, Yong-Chul Kim* | European Journal of Medicinal Chemistry 2022, 240, 114556 | 2022 | https://doi.org/10.1016/j.ejmech.2022.114556 | 2022.10.05 | 학 | |
| Anti-biofilm effects of sinomenine against Staphylococcus aureus | Su-Jin Yum, Hee Gon Jeong* & Seung Min Kim* | Food Science and Biotechnology | 2022 | https://doi.org/10.1007/s10068-022-01174-0 | 2022.09.21 | 학 | |
| Combining structure-based pharmacophore modeling and machine learning for the identification of novel BTK inhibitors | Tanuj Sharma, Venu Venkatarame Gowda Saralamma, Duk Chul Lee, Mohammad Azhar Imran, Jaehyuk Choi, Mohammad Hassan Baig*, Jae-June Dong* | International Journal of Biological Macromolecules 2022, 222, 239-250 | 2022 | https://doi.org/10.1016/j.ijbiomac.2022.09.151 | 2022.09.24 | 산 | |
| Discovery of GSK3β Inhibitors through In Silico Prediction-and-Experiment Cycling Strategy, and Biological Evaluation | Yuno Lee, Sae-Bom Yoon, Hyowon Hong, Hyun Young Kim, Daeyoung Jung, Byoung-San Moon, Woo-Kyu Park, Sunkyung Lee, Hyukjin Kwon, Jihyeong Park, Heeyeong Cho* | Molecules 2022, 27(12), 3825 | 2022 | https://doi.org/10.3390/molecules27123825 | 2022.06.14 | 연 | |
| CDI Exerts Anti-Tumor Effects by Blocking the FoxM1-DNA Interaction | Woo Dae Jang, Mi Young Lee, Jihye Mun, Gyutae Lim and Kwang-Seok Oh* | Biomedicines 2022, 10, 1671 | 2022 | https:// doi.org/10.3390/ biomedicines10071671 | 2022.07.11 | 연 | |
| AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis | Dae Gyu Kim, Yongseok Choi, Yuno Lee, Semi Lim, Jiwon Kong, JaeHa Song, Younah Roh, Dipesh S. Harmalkar, Kwanshik Lee, Ja-il Goo, Hye Young Cho, Ameeq Ul Mushtaq, Jihye Lee, Song Hwa Park, Doyeun Kim, Byung Soh Min, Kang Young Lee, Young Ho Jeon, Sunkyung Lee, Kyeong Lee* & Sunghoon Kim* | Nature Communications, 2022, 13:2572 | 2022 | https://doi.org/10.1038/s41467-022-30149-2 | 2022.05.11 | 학 | |
| Novel Thioxothiazolo[3,4-a]quinazolin-5(4H)-one Derivatives as BKCa Channel Activators for Urinary Incontinence | Eun Jung Bae, Heeji Jo, Seong Soon Kim, Dae-Seop Shin, Jung Yoon Yang, Myung Ae Bae, Pyeonghwa Jeong, Chul-Seung Park*, and Jin Hee Ahn* | ACS Medicinal Chemistry Letters, online | 2022 | https://doi.org/10.1021/acsmedchemlett.2c00070 | 2022.06.21 | 학 | |
| BayeshERG: a robust, reliable and interpretable deep learning model for predicting hERG channel blockers | Hyunho Kim, Minsu Park, Ingoo Lee, Hojung Nam* | Briefings in Bioinformatics, 2022, bbac211 | 2022 | https://doi.org/10.1093/bib/bbac211 | 2022.06.17 | 학 | |
| Discovery and characterization of a potent activator of the BKCa channel that relives overactive bladder syndrome in rats | Heeji Jo, Eun Jung Bae, Narasaem Lee, Jae Won Kwon, Suhan Cho, Sung Joon Kim, Jin Hee Ahn, Chul-Seung Park* | European Journal of Pharmacology | 2022 | https://doi.org/10.1016/j.ejphar.2022.175055 | 2022.07.15 | 학 | |
| Eltrombopag as an Allosteric Inhibitor of the METTL3-14 Complex Affecting the m6A Methylation of RNA in Acute Myeloid Leukemia Cells | Je-Heon Lee, Namjeong Choi, Subin Kim, Mi Sun Jin*, Haihong Shen* and Yong-Chul Kim* | Pharmaceuticals 2022, 15(4), 440 | 2022 | https://doi.org/10.3390/ph15040440 | 2022.04.01 | 학 | |
| 22 | Discovery of harmalanium halides as anti-ovarian cancer agents | Yunha Choi, Sang Hee Ji, Vineet Patil, Eun Hye Kim, Hoyeong Park, Seong Hwan Kim*, Pilho Kim* | Bulletin of the Korean Chemical Society 2022, 43(4), 559-563 | 2022 | https://doi.org/10.1002/bkcs.12498 | 2022.02.16 | 연 |
| 23 | Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin | Na Hui Kim, Minji Kwon, Jiwoo Jung, Hyo Byeong Chae, Jiwoo Lee, Yeo-Jun Yoon, In Seok Moon, Ho K. Lee, Wan Namkung, Konstantina M. Stankovic, Se A. Lee, Jong Dae Lee* & Sin-Aye Park* | Acta Pharmacologica Sinica | 2022 | https://doi.org/10.1038/s41401-022-00908-4 | 2022.04.27 | 학 |
| 24 | Discovery and synthesis of 1,2,4-oxadiazole derivatives as novel inhibitors of Zika, dengue, Japanese encephalitis, and classical swine fever virus infections | Sangwoo Nam, Hyo Gyeong Na, Eun Hye Oh, Eunhye Jung, Yeon Hee Lee, Eun Ju Jeong, Yu-Da Ou, Bin Zhou, Sunjoo Ahn, Jin Soo Shin, Soo Bong Han* & Yun Young Go* | Archives of Pharmacal Research | 2022 | https://doi.org/10.1007/s12272-022-01380-8 | 2022.04.20 | 연 |
| 25 | Identification and New Indication of Melanin-Concentrating Hormone Receptor 1 (MCHR1) Antagonist Derived from Machine Learning and Transcriptome-Based Drug Repositioning Approaches | Gyutae Lim , Ka Young You, Jeong Hyun Lee, Moon Kook Jeon, Byung Ho Lee, Jae Yong Ryu* and Kwang-Seok Oh* | International Journal of Molecular Sciences 2022, 23(7), 3807 | 2022 | https://doi.org/10.3390/ijms23073807 | 2022.03.30 | 연 |
| 26 | Discovery of substituted indole derivatives as allosteric inhibitors of m6A-RNA methyltransferase, METTL3-14 complex | Je-Heon Lee,Subin Kim,Mi Sun Jin,Yong-Chul Kim* | DRUG DEVELOPMENT RESEARCH online | 2022 | https://doi.org/10.1002/ddr.21910 | 2022.01.18 | 학 |
| 27 | Synthesis and Structure–Activity Relationship Studies of Benzimidazole-4,7-dione-Based P2X3 Receptor Antagonists as Novel Anti-Nociceptive Agents | Jinsu Bae, Yeo-Ok Kim, Xuehao Han, Myung-Ha Yoon, Woong-Mo Kim,* and Yong-Chul Kim* | Molecules 2022, 27, 1337 | 2022 | https://doi.org/10.3390/molecules27041337 | 2022.02.16 | 학 |
| 28 | Development of in vitro three-dimensional drug screening system for obesity-related metabolic syndrome | Kyoung Jin Choi, Joon Ho Lee, Sung Bum Park, Yoon-Ju Na, Won Hoon Jung ,Hyuk Lee*, Ki Young Kim* | Journal of Pharmacological Sciences 2022, 148(4),377-386 | 2022 | https://doi.org/10.1016/j.jphs.2022.02.002 | 2022.04 | 연 |
| 29 | Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer’s disease mice | Min Hee Park, Kang Ho Park, Byung Jo Choi, Wan Hui Han, Hee Ji Yoon, Hye Yoon Jung, Jihoon Leed, Im-Sook Song, Dong Yu Lim, Min-Koo Choi* , Yang-Ha Lee, Cheol-Min Park, Ming Wang, Jihoon Jo, Hee-Jin Kim*, Seung Hyun Kim*, Edward H. Schuchman, Hee Kyung Jin and Jae-sung Bae | PNAS 2022, 119(3), e2115082119 | 2022 | https://doi.org/10.1073/pnas.2115082119 | 2022.01.13 | 학 |
| 30 | Discovery of Mycobacterium tuberculosis Rv3364c-Derived Small Molecules as Potential Therapeutic Agents to Target SNX9 for Sepsis | Daeun Lee, Eunbi Lee, Sein Jang, Kyungmin Kim, Euni Cho, Seok-Jun Mun, Wooic Son, Hye-In Jeon, Hyo Keun Kim, Young Jin Jeong, Yuno Lee, Ji Eun Oh, Hye Hyun Yoo, Youngbok Lee, Sun-Joon Min,* and Chul-Su Yang* | Journal of Medicinal Chemistry, 2022, online | 2022 | https://doi.org/10.1021/acs.jmedchem.1c01551 | 2022.01.04 | 학 |
| 31 | Discovery and Characterization of a Novel MASTL Inhibitor MKI-2 Targeting MASTL-PP2A in Breast Cancer Cells and Oocytes | Minsung Kang, Chijung Kim, Jiyeon Leem, Ye-hyun Kim, Young-ju Kwon, Yi Na Yoon, Chong Hak Chae, Jiyeon Ahn, Kwan-Young Jung* , Jeong Su Oh* and Jae-Sung Kim* | Pharmaceuticals 2021, 14(7), 647 | 2021 | https://doi.org/10.3390/ph14070647 | ||
| 32 | Chemical Inhibitors of the Conserved Bacterial Transcriptional Regulator DksA1 Suppressed Quorum Sensing-Mediated Virulence of Pseudomonas aeruginosa | Kyung Bae Min, Wontae Hwang, Kang-Mu Lee, June Beom Kim, Sang Sun Yoon* | Journal of Biological Chemistry 2021, 296, 100576 | 2021 | https://doi.org/10.1016/j.jbc.2021.100576 | ||
| 5 | Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2–Depleted Splice Variant of Aminoacyl–Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70S | Dae Gyu Kim, Srigouri Huddar, Semi Lim, Jiwon Kong, Yuno Lee, Chul Min Park, Seungbeom Lee, Young-Ger Suh, Minkyoung Kim, Kyeong Lee, Sunkyung Lee and Sunghoon Kim* | The Journal of Pharmacology and Experimental Therapeutics 2021, 379(3), 358-371 | 2021 | https://doi.org/10.1124/jpet.121.000766 | ||
| 6 | New quinoxaline compounds as DPP-4 inhibitors and hypoglycemics: design, synthesis, computational and bio-distribution studies | Yasmin M. Syam, Manal M. Anwar, Somaia S. Abd El-Karim, Samia A. Elseginy, Basma M. Essa and Tamer M. Sakr | RSC Advances 2021,11, 36989-37010 | 2021 | https://pubs.rsc.org/en/content/articlelanding/2021/RA/D1RA06799K | ||
| 7 | Di (Isoquinolin-1-Yl) Sulfane (DIQS) Inhibits Melaninogenesis by Modulating PKA/CREB and MAPK Signaling Pathways | Jung Yoon Yang, Dae-Seop Shin, Kyu-Seok Hwang, Seong Soon Kim, Byung Hoi Lee, Se Hwan Ahn, Jin Hee Ahn and Myung Ae Bae* | Cosmetics 2021, 8(4), 104 | 2021 | https://doi.org/10.3390/cosmetics8040104 | ||
| 8 | Aberrant activation of the CD45-Wnt signaling axis promotes stemness and therapy resistance in colorectal cancer cells | So-Yeon Park, Ji-Young Kim, Gyu-Beom Jang, Jang-Hyun Choi, Jee-Heun Kim, Choong-Jae Lee, Sunjae Lee, Jeong-Heum Baek, Kwan-Kyu Park, Jin-Man Kim, Hee Jin Chang, Nam-Chul Cho, and Jeong-Seok Nam* | Theranostics 2021, 11(18), 8755-8770 | 2021 | https://www.thno.org/v11p8755.htm | ||
| 9 | Development of a FOXM1-DBD Binding Assay for High-Throughput Screening Using TR-FRET Assay | Mi Young Lee, Chae Eun Haam, Jihye Mun, Gyutae Lim, Byung Ho Lee, and Kwang-Seok Oh* | Biological and Pharmaceutical Bulletin 2021, 44(10), 1484–1491 | 2021 | https://www.jstage.jst.go.jp/article/bpb/44/10/44_b21-00322/_pdf | ||
| 10 | Screening of small molecules attenuating biofilm formation of Acinetobacter baumannii by inhibition of ompA promoter activity | Seok Hyeon Na, Hyejin Jeon, Man Hwan Oh, Yoo Jeong Kim & Je Chul Lee* | Journal of Microbiology 2021, 59, 871–878 | 2021 | https://doi.org/10.1007/s12275-021-1394-z | ||
| 11 | Identification of new IL-7Rα small-molecule agonists: a multi-computational approach | J-Y Lee, K Lee, B Koh | SAR and QSAR in Environmental Research 2021, 32, 719-729 | 2021 | https://doi.org/10.1080/1062936X.2021.1969684 | ||
| 12 | Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1 | Jain Ha, Sewoong Lee, Jiyoung Park, Jihye Seo, Eunjeong Kang, Haelim Yoon, Ba Reum Kim, Hyeon Kyu Lee, Seong Eon Ryu* & Sayeon Cho* | Scientific Reports 2021, 11:16765 | 2021 | https://doi.org/10.1038/s41598-021-95933-4 | ||
| 13 | A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses | Dae-Gyun Ahn, Gun Young Yoon, Sunhee Lee, Keun Bon Ku, Chonsaeng Kim, Kyun-Do Kim, Young-Chan Kwon, Geon-Woo Kim, Bum-Tae Kim and Seong-Jun Kim* | Viruses 2021, 13(8), 1639 | 2021 | https://doi.org/10.3390/v13081639 | ||
| 14 | Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes | Miri Choi, Ae-kyeong Kim, Youngwook Ham, Joo-Youn Lee, Daeyong Kim, Ansook Yang, Min Ju Jo, Eunyoung Yoon, Jung-Nyoung Heo, Sang-Bae Han, Min-Hyo Ki, Kyu-Sun Lee, Sungchan Cho* | Phytomedicine 2021, 92, 153695 | 2021 | https://doi.org/10.1016/j.phymed.2021.153695 | ||
| 15 | PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease | Areum Jo, Yunjong Lee, Tae-In Kam, Sung-Ung Kang, Stewart Neifert, Senthilkumar S. Karuppagounder, Rin Khang, Hojin Kang, Hyejin Park, Shih-Ching Chou, Sungtaek Oh, Haisong Jiang, Deborah A. Swing, Sangwoo Ham, Sheila Pirooznia, George K. E. Umanah, Xiaobo Mao, Manoj Kumar, Han Seok Ko, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Shaida A. Andrabi, Chi-Hu Park, Ji-Yeong Lee, Hanna Kim, Hyein Kim, Hyojung Kim, Jin Whan Cho, Sun Ha Paek, Chan Hyun Na, Lino Tessarollo, Valina L. Dawson, Ted M. Dawson*, Joo-Ho Shin* | Science Translational Medicine 2021, 13(604), eaax8891 | 2021 | https://stm.sciencemag.org/content/scitransmed/13/604/eaax8891.full.pdf | ||
| 16 | Antiviral Activity of Isoquinolone Derivatives against Influenza Viruses and Their Cytotoxicity | Yejin Jang, Jinhe Han, Xiaoli Li, Hyunjin Shin, Won-Jea Cho* and Meehyein Kim* | Pharmaceuticals 2021, 14(7), 650 | 2021 | https://doi.org/10.3390/ph14070650 | ||
| 17 | Efficient kinetic resolution in the asymmetric transfer hydrogenation of 3-aryl-indanones: applications to a short synthesis of (+)-indatraline and a formal synthesis of (R)-tolterodine† | Songsoon Park, Hyeon-Kyu Lee* | RSC Advances 2021,11, 23161-23183 | 2021 | https://doi.org/10.1039/D1RA04538E | ||
| 18 | SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation | Hye Jin Shin, Keun Bon Ku, Gun Young Yun, Hyun-Woo Moon, Chonsaeng Kim, Bum-Tae Kim, Jong-Won Oh, Aleem Siddiqui, and Seong-Jun Kim,* | Research Square 2021, online | 2021 | https://doi.org/10.21203/rs.3.rs-593889/v1 | ||
| 19 | Structure-Based Virtual Screening: Identification of a Novel NS2B-NS3 Protease Inhibitor with Potent Antiviral Activity against Zika and Dengue Viruses | Hye Jin Shin, Mi-Hwa Kim, Joo-Youn Lee, Insu Hwang, Gun Young Yoon, Hae Soo Kim, Young-Chan Kwon, Dae-Gyun Ahn, Kyun-Do Kim, Bum-Tae Kim, Seong-Jun Kim*, Chonsaeng Kim* | Microorganisms 2021, 9(3), 545 | 2021 | https://doi.org/10.3390/microorganisms9030545 | ||
| 20 | Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced lipotoxicity and gluconeogenesis in a murine model | Hye-Eun Choi, YuSik Kim, Han-Joo Lee, Hyae Gyeong Cheon* | European Journal of Pharmacology 2021, 899, 174011 | 2021 | https://doi.org/10.1016/j.ejphar.2021.174011 | ||
| 21 | A new KSRP-binding compound suppresses distant metastasis of colorectal cancer by targeting the oncogenic KITENIN complex | Jeong A Bae, Woo Kyun Bae, Sung Jin Kim, Yoo-Seung Ko, Keon Young Kim, So-Yeon Park, Young Hyun Yu, Eun Ae Kim, Ik Joo Chung, Hangun Kim, Hyung-Ho Ha & Kyung Keun Kim | Molecular Cancer 2021, 20, 78 | 2021 | https://doi.org/10.1186/s12943-021-01368-w | ||
| 22 | Anti-Cancer Effects of Glaucarubinone in the Hepatocellular Carcinoma Cell Line Huh7 via Regulation of the Epithelial-To-Mesenchymal Transition-Associated Transcription Factor Twist1 | Jihye Seo, Jain Ha, Eunjeong Kang, Haelim Yoon, Sewoong Lee, Shi Yong Ryu, Kwonseop Kim and Sayeon Cho* | International Journal of Molecular Sciences 2021, 22(4), 1700 | 2021 | https://doi.org/10.3390/ijms22041700 | ||
| 23 | Discovery of μ,δ-Opioid Receptor Dual-Biased Agonists That Overcome the Limitation of Prior Biased Agonists | Jin Hee Lee, Suh-Youn Shon, Woojin Jeon, Sung-Jun Hong, Junsu Ban, and Do Sup Lee* | ACS Pharmacology & Translational Science 2021, online | 2021 | https://doi.org/10.1021/acsptsci.1c00044 | ||
| 24 | Sildenafil prevents HDACi-induced Epstein-Barr virus reactivation through the PKG pathway in NK/T cell lymphoma; potential implications for HDACi-mediated fatal complications | Joo Hyun Kim, Won Seog Kim*, Chaehwa Park* | Antiviral Research 2021, 189, 105063 | 2021 | https://doi.org/10.1016/j.antiviral.2021.105063 | ||
| 25 | Identification of non-covalent 3C-like protease inhibitors against severe acute respiratory syndrome coronavirus-2 via virtual screening of a Korean compound library | Joo-Youn Lee, Chih-Jung Kuo, Jin Soo Shin, Eunhye Jung, Po-Huang Liang*, and Young-Sik Jung* | Bioorganic & Medicinal Chemistry Letters 2021, 42, 128067 | 2021 | https://doi.org/10.1016/j.bmcl.2021.128067 | ||
| 26 | Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments | Jun Young Lee, Young Sup Shin, Sangeun Jeon, Se In Lee, Soojin Noh, Jung-Eun Cho, Min Seong Jang, Seungtaek Kim, Jong Hwan Song, Hyoung Rae Kim, Chul Min Park* | Bioorganic & Medicinal Chemistry Letters 2021, 39, 127885 | 2021 | https://doi.org/10.1016/j.bmcl.2021.127885 | ||
| 27 | Antimicrobial activity of IDD-B40 against drug-resistant Mycobacterium tuberculosis | Md Imtiazul Islam, Hoonhee Seo, Sukyung Kim, Venkata S. Sadu, Kee-In Lee & Ho-Yeon Song | Scientific Reports 2021,11,740 | 2021 | https://www.nature.com/articles/s41598-020-80227-y | ||
| 28 | Radicicol Inhibits Chikungunya Virus Replication by Targeting Nonstructural Protein-2 | Sangwoo Nam, Yun Ji Ga, Joo-Youn Lee, Woo-Yeon Hwang, Eunhye Jung, Jinsoo Shin, Weiyi Chen, Gildon Choi, Bin Zhou, Jung-Yong Yeh, Yun Young Go* | Antimicrobial Agents and Chemotherapy 2021, 65(7), e00135-21 | 2021 | https://doi.org/10.1128/AAC.00135-21 | ||
| 29 | Application of the antitussive agents oxelaidin and butamirate as anti-glioma agents | Sook-Ja Lee, Seon-Yong Yeom, Jee-Young Lee & Chaehwa Park* | Scientific Reports 2021, 11:10145 | 2021 | https://doi.org/10.1038/s41598-021-89238-9 | ||
| 30 | Novel brd4 inhibitors with a unique scaffold exhibit antitumor effects | Young Hun Kim, Minsung Kim, Ji Eun Kim, Miyoun Yoo, Heung Kyoung Lee, Chong Ock Lee, Minjin Yoo, Kwan-Young Jung, Yeongrin Kim, Sang Un Choi, Chi Hoon Park* | Oncology Letters 2021, 21(6), 473 | 2021 | https://doi.org/10.3892/ol.2021.12734 | ||
| 31 | TIMP-1-expressing breast tumor spheroids for the evaluation of drug penetration and efficacy | In Yeong Bae, Wooshik Choi, Seung Ja Oh, Chansoo Kim, Sang-Heon Kim* | Bioengineering & Translational Medicine 2021, e10286 | 2021 | https://doi.org/10.1002/btm2.10286 | ||
| 32 | A microwave-assisted synthetic approach to analyzing disubstituted pyrrolo[2,3-d]pyrimidine diversity via ligand-free Cu-catalyzed N-arylation | Chang Sung Hong, Seung Yeong Park, Jeong Seob Byeon, Eul Kgun Yum* | Bulletin of the Korean Chemical Society 2021, 42(12), 1641-1649 | 2021 | https://doi.org/10.1002/bkcs.12422 | ||
| 33 | Therapeutic Effects of Inhibitor of ompA Expression against Carbapenem-Resistant Acinetobacter baumannii Strains | Seok-Hyeon Na, Hyejin Jeon, Man-Hwan Oh, Yoo-Jeong Kim, Mingi Chu, Ill-Young Lee and Je-Chul Lee* | International Journal of Molecular Sciences 2021, 22(22), 12257 | 2021 | https://doi.org/10.3390/ijms222212257 | ||
| 34 | In Silico Exploration of Conformational Dynamics and Novel Inhibitors for Targeting MEF2-Associated Transcriptional Activity | Ayisha Zia Orcid, Muhammad Imran and Sajid Rashid* | Journal of Chemical Information and Modeling2020, 60, 1892−1909 | 2020 | https://doi.org/10.1021/acs.jcim.0c00008 | ||
| 35 | Development and structure-activity relationship study of SHP2 inhibitor containing3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene | Bohee Kim, Seungjin Jo, Sung Bum Park, Chong Hak Chae, Kwangho Lee, Byumseok Koh*, Inji Shin* | Bioorganic & Medicinal Chemistry Letters2020, 30(1), 126756 | 2020 | https://doi.org/10.1016/j.bmcl.2019.126756 | ||
| 36 | Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agent | Bui Thi Bich Hanh, June-Woo Park, Tae Ho Kim, Jae-Sung Kim, Chul-Su Yang, Kiseok Jang, Jinsheng Cui, Dong-Chan Oh and Jichan Jang* | Molecules2020, 25(7), 1597 | 2020 | https://doi.org/10.3390/molecules25071597 | ||
| 37 | Discovery of a Novel Chemical Scaffold Against Mutant Isocitrate Dehydrogenase 1 (IDH1) | Chung Hyo Kang, Sang Un Choi, You Hwa Son, Heung Kyoung Lee, Hye Gwang Jeong , Chang-Soo Yun, Sunjoo Ahn, Chi Hoon Park | Anticancer Research | 2020 | http://ar.iiarjournals.org/content/40/9/4929 | ||
| 38 | Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2 | Dae Gyu Kim, Chul Min Park, Srigouri Huddar, Semi Lim, Sunghoon Kim*, Sunkyung Lee* | Molecules2020, in press | 2020 | https://chembank.org/%ed%99%9c%ec%9a%a9%eb%85%bc%eb%ac%b8/ | ||
| 39 | Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity | Dong-Gyun Kim, Sujin Cho, Kyu-Yeon Lee, Seung-Ho Cheon, Hye-Jin Yoon, Joo-Youn Lee, Dongyoon Kim, Kwang-Soo Shin, Choong-Hyun Koh, Ji Sung Koo, Yuri Choi, Hyung Ho Lee, Yu-Kyoung Oh, Yoo-Seong Jeong, Suk-Jae Chung, Moonkyu Baek, Kwan-Young Jung, Hyo Jin Lim, Hyoun Sook Kim, Sung Jean Park, Jeong-Yeon Lee, Sang Jae Lee* & Bong-Jin Lee* | Cellular and Molecular Life Sciences, 2021, 78(1), 207-225 | 2020 | https://doi.org/10.1007/s00018-020-03490-2 | ||
| 40 | Peripheral Inhibition of Small C‐Terminal Domain Phosphatase 1 With Napthoquinone Analogs | Harikrishna Reddy Rallabandi, Dongsun Lee, Jinmo Sung, YoungJun Kim | Bulletin of the Korean Chemical Society2020, in press | 2020 | https://doi.org/10.1002/bkcs.12051 | ||
| 41 | Autophagic inhibition via lysosomal integrity dysfunction leads to antitumor activity in glioma treatment | Hui-Yun Hwang, Yoon Sun Cho, Jin Young Kim, Ki Na Yun, Jong Shin Yoo, Eunhyeong Lee, Injune Kim and Ho Jeong Kwon* | Cancers2020, 12(3), 543 | 2020 | https://doi.org/10.3390/cancers12030543 | ||
| 42 | TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation | Hyun-Kyoung Kim, Kashi Raj Bhattarai, Raghu Patil Junjappa, Jin Hee Ahn, Suvarna H. Pagire, Hyun Ju Yoo, Jaeseok Han, Duckgue Lee, Kyung-Woon Kim, Hyung-Ryong Kim *, Han-Jung Chae* | Nature Communications | 2020 | https://www.nature.com/articles/s41467-020-17802-4 | ||
| 43 | Identification of a New Chemotype of Anti-Obesity Compounds by Ensemble Screening | Hyunkyung Cho, Joo-Youn Lee, Sang Yoon Choi, Chaemin Lim, Min-Kyoung Park, Hyejin An, Jeong Ok Lee, Minsoo Noh, Seunghee Lee* and Sanghee Kim* | ACS Omega2020, 5, 8, 4338-4346 | 2020 | https://doi.org/10.1021/acsomega.9b04454 | ||
| 44 | Role of RS-1 derivatives in homology-directed repair at the human genome ATG5 locus | In-Sook Jeon, Jae-Cheon Shin, Seung Ryul Kim, Kwan Sik Park, Hyun Jung Yoo, Kwang Youl Lee, Hak-Kyo Lee, Joong-Kook Choi | Archives of Pharmacal Research2020, in press | 2020 | https://link.springer.com/article/10.1007/s12272-020-01226-1 | ||
| 45 | DeepHIT: a deep learning framework for prediction of hERG-induced cardiotoxicity | Jae Yong Ryu*, Mi Young Lee, Jeong Hyun Lee, Byung Ho Lee and Kwang-Seok Oh* | Bioinformatics2020, 36(10), 3049–3055 | 2020 | https://doi.org/10.1093/bioinformatics/btaa075 | ||
| 46 | L-type Calcium Channel Blocker Enhances Cellular Delivery and Gene Silencing Potency of Cell-Penetrating Asymmetric siRNAs | Jeong Yong Choe, Da Seul Son, Yanghee Kim, Jun-kyoung Lee, Hanho Shin, Won Jun Kim, Young Gyu Kang, Pooja Dua, Sun Woo Hong, June Hyun Park and Dong-ki Lee* | Molecular Pharmaceutics2020, 17, 3, 777-786 | 2020 | https://doi.org/10.1021/acs.molpharmaceut.9b00942 | ||
| 47 | Identification of Diphenoxylate as an Antiviral Agent Against Severe Acute Respiratory Syndrome Coronavirus 2 | Jin Soo Shin Eunhye Jung Yejin Jang Soo Bong Han Meehyein Kim* | ChemRxivs2020, in press | 2020 | https://doi.org/10.26434/chemrxiv.12496547.v1 | ||
| 48 | In silico screening of GABA aminotransferase inhibitors from the constituents of Valeriana officinalis by molecular docking and molecular dynamics simulation study | Jin-Young Park, Yuno Lee, Hee Jae Lee, Yong-Soo Kwon, Wanjoo Chun* | Journal of Molecular Modeling | 2020 | https://link.springer.com/article/10.1007/s00894-020-04495-1#Sec9 | ||
| 49 | Inhibitory effects on Streptococcus mutans of antibacterial agents mixed withexperimental fluoride varnish | Ju-Lee SON, Ah-Jin KIM, Seunghan OH, Ji-Myung BAE | Dental Materials Journal2020, in press | 2020 | https://doi.org/10.4012/dmj.2020-016 | ||
| 50 | Identification of 4-Anilino-6-aminoquinazoline Derivatives as Potential MERS-CoV Inhibitors | Jun Young Lee, Young Sup Shin, Jihye Lee, Sunoh Kwon, Young-hee Jin, Min Seong Jang, Seungtaek Kim, Jong Hwan Song, Hyoung Rae Kim, Chul Min Park* | Bioorganic & Medicinal Chemistry Letters | 2020 | https://www.sciencedirect.com/science/article/pii/S0960894X20305837 | ||
| 51 | Efficacy and pharmacokinetics evaluation of 4-(2-chloro-4-fluorobenzyl)-3-(2-thienyl)-1,2,4-oxadiazol-5(4H)-one (GM-90432) as an anti-seizure agent | Kyu-Seok Hwang, Hyemin Kan, Seong Soon Kim, Jin Sil Chae, Jung Yoon Yang, Dae-Seop Shin, Se Hwan Ahn, Jin Hee Ahn, Jin-Hwa Cho, Il-Sung Jang, Junnyeong Shin, Jaeyoung Joo, Cheol-Hee Kim, Myung Ae Bae* | Neurochemistry International | 2020 | https://doi.org/10.1016/j.neuint.2020.104870 | ||
| 52 | Chemical Inhibitors of DksA1, a Conserved Bacterial Transcriptional Regulator, Suppressed Quorum Sensing-Mediated Virulence in Pseudomonas aeruginosa | Kyung Bae Min, Wontae Hwang, Kang-Mu Lee, Sang Sun Yoon | bioRxiv | 2020 | https://doi.org/10.1101/2020.12.10.420422 | ||
| 53 | A novel tyrosine kinase inhibitor can augment radioactive iodine uptake through endogenous sodium/iodide symporter (NIS) expression in anaplastic thyroid cancer | Ms. Ji Min Oh, Mr. Se Hwan Baek, Dr. Prakash Gangadaran, Dr. Chae Moon Hong, Dr. Ramya Lakshmi Rajendran, Dr. Ho Won Lee, Mr. Liya Zhu, Mr. Arunnehru gopal, Dr. Senthilkumar Kalimuthu, Prof. Shin Young Jeong, Dr. Sang-Woo Lee, Dr. Jaetae Lee, and Dr. Byeong-Cheol Ahn* | Thyroid2020, 30(4), 501-518 | 2020 | https://doi.org/10.1089/thy.2018.0626 | ||
| 54 | Selection and functional identification of a synthetic partial ABA agonist, S7 | Myung Ki Min, Rigyeong Kim, Seok-Jun Moon, Yongsang Lee, Seungsu Han, Sangho Lee & Beom-Gi Kim* | Scientific Reports2020, 10(4) | 2020 | https://doi.org/10.1038/s41598-019-56343-9 | ||
| 55 | A computational drug repurposing approach in identifying the cephalosporin antibiotic and anti-hepatitis C drug derivatives for COVID-19 treatment | Raj Kumar, Vikas Kumar, Keun Woo Lee | Computers in Biology and Medicine | 2020 | https://doi.org/10.1016/j.compbiomed.2020.104186 | ||
| 56 | Application of multi-omics technology for the elucidation of anti-pneumococcal activity of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one (APDQ) derivative against Streptococcus pneumoniae | Sang‑Yeop Lee, Hayoung Lee, Sung Ho Yun, Sangmi Jun, Yujeong Lee, Wooyoung Kim, Edmond Changkyun Park, Joonyoung Baek, Yoonna Kwak, Soojin Noh, Giwan Seo, Soojin Jang, Chul Min Park* & Seung Il Kim* | Scientific Reports | 2020 | https://doi.org/10.1038/s41598-020-77694-8 | ||
| 57 | Identification of new arylsulfide derivatives as anti-melanogenic agents in a zebrafish model | Se Hwan Ahn, Kyu-Seok Hwang, Dae-Seop Shin, Seong Soon Kim, Jung Yoon Yang, Byung Hoi Lee, Eun Jung Bae, Byeong Wook Choi, Myung Ae Bae, Jin Hee Ahn | Bioorganic & Medicinal Chemistry Letters2020, 30(13), 127201 | 2020 | https://doi.org/10.1016/j.bmcl.2020.127201 | ||
| 58 | Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR | Seung Min Kim, Jongmin Park, Myun Soo Kim, Heebum Song, Ala Jo, Hankum Park, Tae Sung Kim, Sang Ho Choi,* and Seung Bum Park | ACS Infectious Diseases | 2020 | https://doi.org/10.1021/acsinfecdis.0c00587 | ||
| 59 | Discovery of 4-hydroxy-2-oxo-1,2-dihydroquinolines as potential inhibitors of Streptococcus pneumoniae, including drug-resistant strains | Srigouri Huddar, Chul Min Park, Hyung Jun Kim, Soojin Jang, Sunkyung Lee | Bioorganic & Medicinal Chemistry Letters2020, 30(9), 127071 | 2020 | https://doi.org/10.1016/j.bmcl.2020.127071 | ||
| 60 | Diversification of Heteroaryl‐Aryl Ether via Ligand‐Free, Copper‐Catalyzed O‐Arylation Under Microwave Heating | Sung Min Choi, Jeong Seob Byeon, Eul Kgun Yum* | Bulletin of the Korean Chemical Society | 2020 | https://onlinelibrary.wiley.com/doi/full/10.1002/bkcs.12075 | ||
| 61 | Structural and Functional Study of the Klebsiella pneumoniae VapBC Toxin–Antitoxin System, Including the Development of an Inhibitor That Activates VapC | Sung-Min Kang, Chenglong Jin, Do-Hee Kim, Yuno Lee, Bong-Jin Lee* | Journal of Medicinal Chemistry | 2020 | https://doi.org/10.1021/acs.jmedchem.0c01118 | ||
| 62 | Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles | Yi-Seul Yoon, Yejin Jang, Thomas Hoenen, Heegwon Shin, Younghoon Lee & Meehyein Kim* | BMB Reports2020, 53(3), 166-171 | 2020 | https://doi.org/10.5483/BMBRep.2020.53.3.175 | ||
| 63 | Punicalagin Ameliorates Lupus Nephritis via Inhibition of PAR2 | Yohan Seo, Chin Hee Mun, So-Hyeon Park, Dongkyu Jeon, Su Jeong Kim, Taejun Yoon, Eunhee Ko, Sungwoo Jo, Yong-Beom Park, Wan Namkung, and Sang-Won Lee | International Journal of Molecular Sciences | 2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404282/ | ||
| 64 | Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2 | Young Sup Shin, Jun Young Lee, Soojin Noh, Yoonna Kwak, Sangeun Jeon, Sunoh Kwon, Young-hee Jin, Min Seong Jang, Seungtaek Kim, Jong Hwan Song, Hyoung Rae Kim, Chul Min Park* | Bioorganic & Medicinal Chemistry Letters | 2020 | https://doi.org/10.1016/j.bmcl.2020.127667 | ||
| 65 | Phenylethylamides derived from bacterial secondary metabolites specifically inhibit an insect serotonin receptor | Ariful Hasan, Hyun-Suk Yeom, Jaewook Ryu, Helge B. Bode & Yonggyun Kim | Scientific Reports20358 (2019) | 2019 | https://doi.org/10.1038/s41598-019-56892-z | ||
| 66 | Discovery of (E)-5,5-Difluoro-1-[2-[5-(3-fluorophenyl)pyridin-2-yl]vinyl]octahydrospiro(indene-2,5′-oxazolidin)-2′-one as a PAR1 Antagonist | Chul Min Park, Sunkyung Lee, Song Jong Hwan, Lee Joo Youn | Bulletin of the Korean Chemical Society2019, 40, 658-667 | 2019 | https://doi.org/10.1002/bkcs.11747 | ||
| 67 | Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases | Dahye Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Eun Jung Bae, Mahesh Dighe, Minhee Kim, Kyu Myung Lee, Yoon Kyung Jang, Ashok Kumar Jaladi, Kwan-Young Jung, Eun Kyung Yoo, Hee Eon Gim, Seungmi Lee, Won-Il Choi, Young-In Chi, Jin Sook Song, Myung Ae Bae, Yong Hyun Jeon, Ga-Hyun Lee, Kwang-Hyeon Liu, Taeho Lee, Sungmi Park, Jae-Han Jeon, In-Kyu Lee, and Jin Hee Ahn | Journal of Medicinal Chemistry2019, 62(2), 575-588 | 2019 | https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01168 | ||
| 68 | Identification of a novel turn-on albumin binding small-molecule bioprobe in live zebrafish and its potential application in drug discovery | Hang-Suk Chun,Seo-Jung Han,Dae-Seop Shin,Haushabhau S.Pagire,Suvarna H.Pagire,Gwi Bin Lee,Chong Hak Chae,BoryeongPak,Suk-Won Jin,Young-Tae Chang,Seung Bum Park,Jin Hee Ahn,Myung Ae Bae | Dyes and Pigments2019, 171, 107720 | 2019 | https://doi.org/10.1016/j.dyepig.2019.107720 | ||
| 69 | Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model | Jeong Kun-HeeKim,Dong-Young Kim,GopalakrishnanChandrasekaran,Minhee Kim,Suvarna H.Pagire,Mahesh Dighe,Eun Young Choi,Su-Min Bak,Eun-Young Kim,Myung-Geun Shin,Seok-Yong Choi,Jin Hee Ahn | Bioorganic & Medicinal Chemistry2019, 27(19), 115014 | 2019 | https://doi.org/10.1016/j.bmc.2019.07.030 | ||
| 70 | A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy | Jessica L. Wojtaszek, Nimrat Chatterjee, Javaria Najeeb, Azucena Ramos, Minhee Lee, Ke Bian, Jenny Y. Xue, Benjamin A. Fenton, Hyeri Park, Deyu Li, Michael T. Hemann, Jiyong Hong, Graham C. Walker, and Pei Zhou | Cell2019, 178(1), 152-159 | 2019 | https://doi.org/10.1016/j.cell.2019.05.028 | ||
| 71 | Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors | Ji HyeYoon,Jun Young Lee,Jihye Lee,Young Sup Shin,Sangeun Jeon,Dong Eon Kim,Jung Sun Min,Jong Hwan Song,Seungtaek Kim,Sunoh Kwon,Young-hee Jin,Min Seong Jang,Hyoung Rae Kim,Chul Min Park | Bioorganic & Medicinal Chemistry LettersVolume 29, Issue 23, 1 December 2019, 126727 | 2019 | https://doi.org/10.1016/j.bmcl.2019.126727 | ||
| 72 | Identification of a novel SIRT7 inhibitor as anticancer drug candidate | Ji-Hye Kim, Da hee Kim, Suk Joon Cho, Kwan-Young Jung, Jong-Hoon Kim, Jun Mi Lee, Hee Jung Jung, Kwang Rok Kim | Biochemical and Biophysical Research Communications2019, 508(2), 451-457 | 2019 | https://doi.org/10.1016/j.bbrc.2018.11.120 | ||
| 73 | The anti-biofilm and anti-virulence activities of trans-resveratrol and oxyresveratrol against uropathogenic Escherichia coli | Jin-Hyung Lee,Yong-Guy Kim,Chaitany Jayprakash Raorane,Shi Yong Ryu,Jae-Jin Shim &Jintae Lee | The Journal of Bioadhesion and Biofilm Research2019, 35(7) 758-767 | 2019 | https://doi.org/10.1080/08927014.2019.1657418 | ||
| 74 | DITMD-induced mitotic defects and apoptosis in tumor cells by blocking the polo-box domain-dependent functions of polo-like kinase 1 | Ka-Ul Kim, Ju Hee Lee, Mi Young Lee, Chong Hak Chae, Jeong Hyun Lee, Byung Ho Lee, Kwang-Seok Oh | European Journal of Pharmacology2019, 847, 113-122 | 2019 | https://doi.org/10.1016/j.ejphar.2019.01.032 | ||
| 75 | In vitro activity of DNF-3 against drug resistant Mycobacterium tuberculosis | Md Imtiazu Islam, Choi Moon Han, Hoonhee Seo, Sukyung Kim, Hafij Al Mahmud, Kung-Woo Nam, Byung-Eui Lee, Venkata S. Sadu, Kee-In Lee, Ho-Yeon Song | International Journal of Antimicrobial Agents2019, 54(1), 69-74 | 2019 | https://doi.org/10.1016/j.ijantimicag.2019.02.013 | ||
| 76 | Potential biomarkers and antagonists for fluoranthene-induced cellular toxicity of bone marrow derived mesenchymal stem cells | Md Moinul Hoque,Young Eun Lee, Hye Ran Kim,and Myung Geun Shin | Synapse2019 Dec;54(4):253-261 | 2019 | https://doi.org/10.5045/br.2019.54.4.253 | ||
| 77 | Homoharringtonine Induces Apoptosis in Human Colorectal Carcinoma HCT116 Cells Via Downregulation of Wnt/β-Catenin Signaling Cascade | Mikyung Park, Hojeong Kwon, and Seong Hwan Kim | Bulletin of the Korean Chemical Society2019, 40(2), 196-199 | 2019 | https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.11662 | ||
| 78 | A nano sensor for sensitive and selective detection of Cu2+ based on fluorescein: Cell imaging and drinking water analysis | Prasad G.Mahajan, Nilam C.Dige, Balasaheb D.Vanjare, Seong-Hui Eo, Song Ja Kim, Ki Hwan Lee | Spectrochimica Acta Part A : Molecular and Biomolecular Spectroscopy2019, 216, 105-116 | 2019 | https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.11662 | ||
| 79 | Facile synthesis of new quinazolinone benzamides as potent tyrosinase inhibitors: Comparative spectroscopic and molecular docking studies | Prasad G.Mahajan,Nilam C.Dige,Balasaheb D.Vanjare,Hussain Raza,Mubashir Hassan,Sung-Yum Seo,Chong- Hyeak Kim,Ki Hwan Lee | Journal of Molecular StructureVolume 1198, 15 December 2019, 126915 | 2019 | https://doi.org/10.1016/j.molstruc.2019.126915 | ||
| 80 | Stereoselective Synthesis of Highly Functionalized 5- and 6-Membered Aminocyclitols Starting with a Readily Available 2-Azetidinone | Raghavendra Achary, Hyeong Rae Kim, Hyeon-Kyu Lee | The Journal of Organic Chemistry2019, 84(7), 4263-4272 | 2019 | https://pubs.acs.org/doi/pdf/10.1021/acs.joc.9b00239 | ||
| 81 | Synthesis and Biological Evaluation of PF-543 Derivative Containing Aliphatic Side Chain | Seon Woong Kim, Taeho Lee, Yoon Sin Oh, Sang Mi Shin, Joo-Youn Lee, Sanghee Kim, Dong Jae Baek, and Eun-Young Park | Chemical and Pharmaceutical Bulletin2019, 67(6), 599-603 | 2019 | https://www.jstage.jst.go.jp/article/cpb/67/6/67_c18-00724/_pdf | ||
| 82 | Fluoranthene-Induced Cytotoxicity and Direct Effect of Aryl Hydrocarbon Receptor Antagonist on Hematopoietic Stem Cell Differentiation | Seung-Hyun Yang,Min-Gu Kang,Hye-Ran Kim,Young Eun Lee,Bo Ram Na,Jun Hyung Lee,Jong-Hee Shin,and Myung-Geun Shin | Ann Lab Med2019 Nov;39(6):580-583 | 2019 | https://doi.org/10.3343/alm.2019.39.6.580 | ||
| 83 | Thiostrepton: A Novel Therapeutic Drug Candidate for Mycobacterium abscessus Infection | Tae Ho Kim,Bui Thi Bich Hanh,Guehye Kim,Da-Gyum Lee,June-Woo Park,So Eui Lee,Jae-Sung Kim,Byoung Soo Kim,Sungweon Ryoo,Eun-Kyeong Jo,andJichan Jang | Molecules2019, 24(24), 4511 | 2019 | https://doi.org/10.3390/molecules24244511 | ||
| 84 | Discovery of Small‐Molecule Modulators of Protein–RNA Interactions by Fluorescence Intensity‐Based Binding Assay | Wan Gi Byun Dr. Donghyun Lim Prof. Dr. Seung Bum Park | ChemBioChem2019,20,1–8 | 2019 | https://doi.org/10.1002/cbic.201900467 | ||
| 85 | Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species | Zee-Won Lee, Byoung Sik Kim, Kyung Ku Jang, Ye-Ji Bang, Suhyeon Kim, Nam-Chul Ha, Young Hyun Jung, Hyun Jik Lee, Ho Jae Han, Jong-Seo Kim, Jeesoo Kim, Pramod K. Sahu, Lak Shin Jeong, Myung Hee Kim & Sang Ho Choi | Scientific Reports2019, 9, 436-449 | 2019 | https://www.nature.com/articles/s41598-019-39554-y | ||
| 86 | Anti-inflammatory effects of a novel compound, MPQP, through the inhibition of IRAK1 signaling pathways in LPS-stimulated RAW 264.7 macrophages | Ba Reum Kim, Young-Chang Cho & Sayeon Cho | BMB Reports2018, 51(6), 308-313 | 2018 | https://doi.org/10.5483/BMBRep.2018.51.6.064 | ||
| 87 | Identification of N-(5-(phenoxymethyl)-1,3,4-thiadiazol-2-yl)acetamide derivatives as novel protein tyrosine phosphatase epsilon inhibitors exhibiting anti-osteoclastic activity | Bonsu Ku, Hye-Yeoung Yun, Kyung WonLee, Ho-Chul Shin, Sang-Rae Lee, Chang Hyen Kim, Hwangseo Park, Kyu Yang Yi, Chang Hoon Lee, Seung Jun Kim | Bioorganic & Medicinal Chemistry Letters2018, 26(18), 5204-5211 | 2018 | https://doi.org/10.1016/j.bmc.2018.09.022 | ||
| 88 | QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species | Byoung Sik Kim, Song Yee Jang, Ye-ji Bang, Jungwon Hwang, Youngwon Koo, Kyung Ku Jang, Dongyeol Lim, Myung Hee Kim, Sang Ho Choi | mBio2018, 9(1), e02262-17 | 2018 | http://dx.doi.org/10.1128/mBio.02262-17 | ||
| 89 | Design and Synthesis of Novel 3-(2-Aminopyridin-3-yl)-1,2,4-Triazolo[4,3-b]Pyridazine Derivatives as a Reversible Bruton’s Tyrosine Kinase Inhibitors | Chi Hoon Park, Dukwoon Kim, Hyeonseok Jung, Jeong Hee Jeon, Raghavendra Achary, Joo-Youn Lee, Pilho Kim, Heejung Jung, Jong Yeon Hwang, Do Hyun Ryu, Jae Du Ha, and Sung Yun Cho | Bulletin of the Korean Chemical Society2018, 온라인 게재 | 2018 | http://dx.doi.org/10.1002/bkcs.11485 | ||
| 90 | Restoring Let-7 microRNA Biogenesis Using a Small-Molecule Inhibitor of the Protein-RNA Interaction | Donghyun Lim, Wan Gi Byun, and Seung Bum Park | ACS Medicinal Chemistry Letters2018, 9(12), 1181-1185 | 2018 | https://doi.org/10.1021/acsmedchemlett.8b00323 | ||
| 91 | Identification and Characterization of NTB451 as a Potential Inhibitor of Necroptosis | Eun-Jung In, Yuno Lee, Sushruta Koppula, Tae-Yeon Kim, Jun-Hyuk Han, Kwang-Ho Lee, and Tae-Bong Kang | Molecules2018, 23(11), 2884-2899 | 2018 | https://doi.org/10.3390/molecules23112884 | ||
| 92 | Identification of quinone analogues as potential inhibitors of picornavirus 3C protease in vitro | Eunhye Jung, Joo-Youn Lee, Ho Jeong Kim, Chung-Kyu Ryu, Kee-In Lee, Meehyein Kim, Chong-Kyo Lee, Yun Young Go | Bioorganic & Medicinal Chemistry Letters2018, in press | 2018 | https://doi.org/10.1016/j.bmcl.2018.05.046 | ||
| 93 | A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes | Hyejin Lim, Yu-Mi Lim, Kook Hwan Kim, Young Eui Jeon, Kihyoun Park, Jinyoung Kim, Hui-Yun Hwang, Dong Jin Lee, Haushabhau Pagire, Ho Jeong Kwon, Jin Hee Ahn & Myung-Shik Lee | NATURE COMMUNICATIONS2018, 9, 1438 | 2018 | http://dx.doi.org/10.1038/s41467-018-03939-w | ||
| 94 | DBU-Promoted Dynamic Kinetic Resolution in Rh-Catalyzed Asymmetric Transfer Hydrogenation of 5-Alkyl Cyclic Sulfamidate Imines: Stereoselective Synthesis of Functionalized 1,2-Amino Alcohols | Hyeong Rae Kim, Raghavendra Achary, and Hyeon-Kyu Lee | Journal of Organic Chemistry2018, 83(19), 11987-11999 | 2018 | https://doi.org/10.1021/acs.joc.8b01892 | ||
| 95 | Reverting iodine avidity of radioactive-iodine refractory thyroid cancer with a new tyrosine kinase inhibitor (K905-0266) excavated by high-throughput NIS (sodium iodide symporter) enhancer screening platform using dual reporter gene system | Ji Min Oh, Senthilkumar Kalimuthu, Prakash Gangadaran, Se Hwan Baek, Liya Zhu, Ho Won Lee, Ramya Lakshmi Rajendran, Chae Moon Hong, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee and Byeong-Cheol Ahn | Oncotarget2018, 9(6), 7075-7087 | 2018 | http://dx.doi.org/10.18632/oncotarget.24159 | ||
| 96 | Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells | Ji-Hye Kim, Jun Mi Lee, Jong-Hoon Kim, Kwang Rok Kim | Biochemical and Biophysical Research Communications2018, 503(3), 1415-1421 | 2018 | https://doi.org/10.1016/j.bbrc.2018.07.057 | ||
| 97 | Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro | Jin Soo Shin, Eunhye Jung, Meehyein Kim, Ralph S. Baric and Yun Young Go | Viruses2018, 10, 283 | 2018 | http://dx.doi.org/10.3390/v10060283 | ||
| 98 | Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation | Jitendra Shrestha, Sung Hwan Ki, Sang Mi Shin, Seon Woong Kim, Joo-Youn Lee, Hee-Sook Jun, Taeho Lee, Sanghee Kim, Dong Jae Baek and Eun-Young Park | Molecules2018, 23(11), 2750-2761 | 2018 | https://doi.org/10.3390/molecules23112750 | ||
| 99 | Suppression of NRF2/ARE by convallatoxin sensitises A549 cells to 5-FU-mediated apoptosis | June Lee, Jong-Su Kang, Le Ba Nam, Ok-Kyung Yoo, and Young-Sam Keum | Free Radical Research2018, 온라인 게재 | 2018 | https://doi.org/10.1080/10715762.2018.1489132 | ||
| 100 | A pivotal role of AMPK signaling in medicarpin-mediated formation of Brown and Beige | Khan Mohammad Imran, Dahyeon Yoon, Yong-Sik Kim | BioFactors2018, 44(2), 168-179 | 2018 | http://dx.doi.org/10.1002/biof.1392 | ||
| 101 | A novel anti-melanogenic agent, KDZ-001, inhibits tyrosinase enzymatic activity | Kyu-Seok Hwang, Jung Yoon Yang, Jooyun Lee, Yu-Ri Lee, Seong Soon Kim, Geum Ran Kim, Jin Sil Chae, Jin Hee Ahn, Dae-Seop Shin, Tae-Young Choi, Myung Ae Bae | Journal of Dermatological Science2018, 89, 165-171 | 2018 | http://dx.doi.org/10.1128/mBio.02262-17 | ||
| 102 | Synthesis and biological evaluation of indazole-4,7-dione derivatives as novel BRD4 inhibitors | Minjin Yoo, Miyoun Yoo, Ji Eun Kim, Heung Kyoung Lee, Chong Ock Lee, Chi Hoon Park, Kwan-Young Jung | Archives of Pharmacal Research2018, 41(1), 46-56 | 2018 | http://dx.doi.org/10.1007/s12272-017-0978-y | ||
| 103 | Effects of a small molecule R-spondin-1 substitute RS-246204 on a mouse intestinal organoid culture | Myeong-Ok Nam, Soojung Hahn, Joo Hyun Jee, Tae-Sun Hwang, Ho Yoon, Dong Hyeon Lee, Min-Soo Kwon and Jongman Yoo | Oncotarget2018, 9(5), 6356-6368 | 2018 | http://dx.doi.org/10.18632/oncotarget.23721 | ||
| 104 | Tandem Rh-Catalyzed Oxidative C?H Olefination and Cyclization of Enantiomerically Enriched Benzo-1,3-Sulfamidates: Stereoselective Synthesis of trans-1,3-Disubstituted Isoindolines | Raghavendra Achary, In-A Jung, and Hyeon-Kyu Lee | Journal of Organic Chemistry2018, 83(7), 3864-3878 | 2018 | http://dx.doi.org/10.1021/acs.joc.8b00204 | ||
| 105 | Psoralidin Stimulates Expression of Immediate-Early Genes and Synapse Development in Primary Cortical Neurons | Seojin Hwang, Seong-eun Lee, Sang-Gun Ahn, Gum Hwa Lee | Neurochemical Research2018, 43(2), 2460-2472 | 2018 | https://link.springer.com/content/pdf/10.1007/s11064-018-2689-2.pdf | ||
| 106 | Mosquitocidal activity of penfluridol as juvenile hormone antagonist | Seok-Hee Lee, Hee Nam Lim, Jae Young Choi, Dong Hwan Park, Byung Hoon Ahn, Ying Fang, Jong Hoon Kim, Min Gu Park, Ra Mi Woo, Bo Ram Lee, Woo Jin Kim, Young Kwan Ko, Ill Young Lee, Yeon Ho Je | Journal of Asia-Pacific Entomology2018, 21, 130-133 | 2018 | https://doi.org/10.1016/j.aspen.2017.11.009 | ||
| 107 | Synthesis and Biological Evaluation of FTY720 (Fingolimod) Derivatives with Aromatic Head Group as Anticancer Agents | Taeho Lee, Hong Seop Moon, Seon Woong Kim, Jitendra Shrestha, Sang Mi Shin, Joo-Youn Lee, Sanghee Kim, Eun-Young Park, and Dong Jae Baek | Chemical and Pharmaceutical Bulletin2018, 66(10), 1015-1018 | 2018 | https://doi.org/10.1248/cpb.c18-00065 | ||
| 108 | Salinomycin Inhibits Influenza Virus Infection by Disrupting Endosomal Acidification and Viral Matrix Protein 2 Function | Yejin Jang, Jin Soo Shin, Yi-Seul Yoon, Yun Young Go, Hye Won Lee, Oh Seung Kwon, Sehee Park, Man-Seong Park, Meehyein Kim | Journal of Virology2018, 92(24), e01441-18 | 2018 | https://doi.org/10.1128/JVI.01441-18 | ||
| 109 | A natural compound, aristoyagonine, is identified as a potent bromodomain inhibitor by mid-throughput screening | Young Hun Kim, Minsung Kim, Miyoun Yoo, Ji Eun Kim, Heung Kyoung Lee, Jung-Nyoung Heo, Chong Ock Lee, Minjin Yoo, Kwan-Young Jung, Chang-Soo Yun, Sung Woong Moon, Hye Kyung Chang, Chul-Woong Chung, Suhkneung Pyo, Sang Un Choi, Chi Hoon Park | Biochemical and Biophysical Research Communications2018, 503, 882-887 | 2018 | https://doi.org/10.1016/j.bbrc.2018.06.091 | ||
| 110 | 실험용 항균성 불소바니쉬의 최소억제농도와 최소살균농도 | 손주리, 김아진, 오승한, 배지명 | Korean Journal of Dental Materials2018, 45(2), 139-146 | 2018 | http://dx.doi.org/10.14815/kjdm.2018.45.2.139 | ||
| 111 | Enterovirus inhibitory activity of C-8-tert-butyl substituted 4-aryl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-ones | Bishyajit Kumar Biswas, Yashwardhan R. Malpani, Neul Ha, Do-Hyun Kwon, Jin Soo Shin, Hae-Soo Kim, Chonsaeng Kim, Soo Bong Han, Chong-Kyo Lee, Young-Sik Jung | Bioorganic & Medicinal Chemistry Letters2017, 27, 3582-3585 | 2017 | http://dx.doi.org/10.1016/j.bmcl.2017.05.030 | ||
| 112 | 3-Amino-1H-pyrazolopyridine Derivatives as a Maternal Embryonic Leucine Zipper Kinase Inhibitor | Chul Min Park, Vithal B. Jadhav, Jong-Hwan Song, Sunkyung Lee, Hee Young Won, Sang Un Choi, and You Hwa Son | Bulletin of the Korean Chemical Society2017, 38(6), 595-602 | 2017 | http://dx.doi.org/10.1002/bkcs.11129 | ||
| 113 | KRICT-9 inhibits neuroinflammation, amyloidogenesis and memory loss in Alzheimer’s disease models | Do Yeon Lee, Chul Ju Hwang, Ji Yeon Choi, Mi Hee Park, Min Ji Song, Ki Wan Oh, Sang Bae Han, Woo Kyu Park, Hee Yeong Cho, Sung Yun Cho, Hye Byn Park, Min Jong Song and Jin Tae Hong | Oncotarget2017, 8(40), 68654-68667 | 2017 | http://dx.doi.org/10.18632/oncotarget.19818 | ||
| 114 | Synthesis and Molecular Modeling Studies of N’-Hydroxyindazolecarboximidamides as Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors | Dong-Ho Lee, Joo-Youn Lee, Jieun Jeong, Miok Kim, Kyung Won Lee, Eunseo Jang, Sunjoo Ahn, Chang Hoon Lee and Jong Yeon Hwang | Molecules2017, 22, 1936-1945 | 2017 | https://doi.org/10.3390/molecules22111936 | ||
| 115 | A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer | E-J Choi, B-J Jung, S-H Lee, H-S Yoo, E-A Shin, H-J Ko, S Chang, S-Y Kim and S-M Jeon | Oncogene2017, 36, 5285-5295 | 2017 | http://dx.doi.org/10.1038/onc.2017.153 | ||
| 116 | Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors | Eun-Jin Han, Hyun Young Kim, Naeun Lee, Nam-Hoon Kim, Seung-Ah Yoo, H. Moo Kwon, Dae-Myung Jue, Yune-Jung Park, Chul-Soo Cho, Tran Quang De, Dae Young Jeong, Hee-Jong Lim, Woo Kyu Park, Ge Hyeong Lee, Heeyeong Cho, Wan-Uk Kim | EBioMedicine2017, 18, 261-273 | 2017 | http://dx.doi.org/10.1016/j.ebiom.2017.03.039 | ||
| 117 | Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R | Gangadhar Rao Mathi, Chung Hyo Kang, Heung Kyoung Lee, Raghavendra Achary, Ha-Yeon Lee, Joo-Youn Lee, Jae Du Ha, Sunjoo Ahn, Chi Hoon Park, Chong Ock Lee, Jong Yeon Hwang, Chang-Soo Yun, Hee Jung Jung, Sung Yun Cho, Hyoung Rae Kim, Pilho Kim | European Journal of Medicinal Chemistry2017, 126, 536-549 | 2017 | http://dx.doi.org/10.1016/j.ejmech.2016.11.046 | ||
| 118 | The Discovery of Novel Protein Tyrosine Phosphatase ε Inhibitors Using a High-throughput Screening Approach | Hye-Yeoung Yun, Bonsu Ku, Hye Seon Lee, Ho-Chul Shin, Jun-Beom Park, Chang Hyen Kim, and Seung Jun Kim | Bulletin of the Korean Chemical Society2017, 38, 44-53 | 2017 | http://dx.doi.org/10.1002/bkcs.11044 | ||
| 119 | Design and Synthesis of Novel Pyrazolo[3,4-d]pyrimidin-1-yl piperidine Derivatives as Bruton’s Tyrosine Kinase Inhibitors | Hyebin Park, Chi Hoon Park, Seung-Tae Kang, Jeong Hee Jeon, Raghavendra Archary, Joo-Youn Lee, Pilho Kim, Heejung Jung, Chang-Soo Yun, Jong Yeon Hwang, Do Hyun Ryu, and Sung Yun Cho | Bulletin of the Korean Chemical Society2017, 38, 278-281 | 2017 | http://dx.doi.org/10.1002/bkcs.11065 | ||
| 120 | An Efficient Copper-catalyzed Nucleophilic Addition to N-Acyliminium Ions Derived from N-Benzyloxycarbonylamino Sulfones: A Novel Approach to C-3 Functionalization of 2-Phenylimidazo[1,2-a]pyridine | Hyeong Jin Park and Jong-Gab Jun | Bulletin of the Korean Chemical Society2017, 38, 1123-1128 | 2017 | http://dx.doi.org/10.1002/bkcs.11228 | ||
| 121 | Identification of Antipneumococcal Molecules Effective Against Different Streptococcus pneumoniae Serotypes Using a Resazurin-Based High-Throughput Screen | Hyung Jun Kim, Namyoul Kim, David Shum, Srigouri Huddar, Chul Min Park, and Soojin Jang | ASSAY and Drug Development Technologies2017, 15(5), 198-209 | 2017 | http://dx.doi.org/10.1089/adt.2017.789 | ||
| 122 | BET Inhibitors as Anticancer Agents : A Patent Review | Imran Ali, Gildon Choi and Kwangho Lee | Recent Patents on Anti-Cancer Drug Discovery2017, 12, 340-364 | 2017 | https://doi.org/10.2174/1574892812666170808121228 | ||
| 123 | Discovery of novel [1,2,4]triazolo[4,3-a]quinoxaline aminophenyl derivatives as BET inhibitors for cancer treatment | Imran Ali, Jooyun Lee, Areum Go, Gildon Choi, Kwangho Lee | Bioorganic & Medicinal Chemistry Letters2017, 27, 4606-4613 | 2017 | http://dx.doi.org/10.1016/j.bmcl.2017.09.025 | ||
| 124 | A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication | Jinwoo Kim, Yu Kyoung Jung, Chonsaeng Kim, Jin Soo Shin, Els Scheers, Joo-Youn Lee, Soo Bong Han, Chong-Kyo Lee, Johan Neyts, Jae-Du Ha, and Young-Sik Jung | Journal of Medicinal Chemistry2017, 60, 5472-5492 | 2017 | http://dx.doi.org/10.1021/acs.jmedchem.7b00175 | ||
| 125 | Identification of novel ALK2 inhibitors and their effect on cancer cells | Minsung Kim, Okran Choi, Suhkneung Pyo, Sang Un Choi, Chi Hoon Park | Biochemical and Biophysical Research Communications2017, 492, 121-127 | 2017 | http://dx.doi.org/10.1016/j.bbrc.2017.08.016 | ||
| 126 | Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cells | Myeong-ok Kim, Min Ho Choe, Yi Na Yoon, Jiyeon Ahn, Minjin Yoo, Kwan-Young Jung, Sungkwan An, Sang-Gu Hwang, Jeong Su Oh, Jae-Sung Kim | Biochemical Pharmacology2017, 144(15), 78-89 | 2017 | http://dx.doi.org/10.1016/j.bcp.2017.08.009 | ||
| 127 | Synthesis of Fluorescent Indazoles by Palladium-Catalyzed Benzannulation of Pyrazoles with Alkynes | Og Soon Kim, Jin Hyeok Jang, Hyun Tae Kim, Su Jin Han, Gavin Chit Tsui, and Jung Min Joo | Organic Letters2017, 19(6), 1450-1453 | 2017 | http://dx.doi.org/10.1021/acs.orglett.7b00410 | ||
| 128 | Stereoselective Synthesis of Functionalized 1, 3-Disubstituted Isoindolines via Rh(III)-Catalyzed Tandem Oxidative Olefination-Cyclization of 4-Aryl-cyclic Sulfamidate-5-Carboxylates | Raghavendra Achary, In-A Jung, Se-Mi Son, and Hyeon-Kyu Lee | The Journal of Organic Chemistry2017, 82, 7223-7233 | 2017 | http://dx.doi.org/10.1021/acs.joc.7b00799 | ||
| 129 | Antimicrobial activity of novel 4H-4-oxoquinolizine compounds against extensively drug-resistant Acinetobacter baumannii strains | Seok Hyeon Na, Hyejin Jeon, Yoo Jeong Kim, Hyo Il Kwon, Gati Noble Selasi, Asiimwe Nicholas, Chang-Soo Yun, Sang Ho Lee, Je Chul Lee | International Journal of Antimicrobial Agents2017, 49, 107-111 | 2017 | http://dx.doi.org/10.1016/j.ijantimicag.2016.10.008 | ||
| 130 | Development of an HTS system to identify natural chemicals that specifically inhibit Escherichia coli O157:H7 adhesion to host cells | Seung Min Kim, Hyun Jung Kim | Food Control2017, 73, 185-192 | 2017 | http://dx.doi.org/10.1016/j.foodcont.2016.08.007 | ||
| 131 | Activity of novel inhibitors of Staphylococcus aureus biofilms | Seung-Gyun Woo, So-Yeon Lee, So-Min Lee, Kyoung-Hee Lim, Eun-Ju Ha, Yong-Bin Eom | Folia Microbiologica2017, 62(2), 157-167 | 2017 | http://dx.doi.org/10.1007/s12223-016-0485-4 | ||
| 132 | Acceleration of osteoblast differentiation by a novel osteogenic compound, DMP-PYT, through activation of both the BMP and Wnt pathways | Su Jung Bae, Hye Joo Kim, Hee Yeon Won, Yong Ki Min and Eun Sook Hwang | Scientific Reports2017, 7, 8455-8464 | 2017 | http://dx.doi.org/10.1038/s41598-017-08190-9 | ||
| 133 | Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors | Sun Jun Park, Eunjin Kim, Miyoun Yoo, Joo-Youn Lee, Chi Hoon Park, Jong Yeon Hwang, Jae Du Ha | Bioorganic & Medicinal Chemistry Letters2017, 27(18), 4399-4404 | 2017 | http://dx.doi.org/10.1016/j.bmcl.2017.08.018 | ||
| 134 | Development of a High-Throughput Assay for Inhibitors of the Polo-Box Domain of Polo-Like Kinase 1 Based on Time-Resolved Fluorescence Energy Transfer | Tae Gi Kim, Ju Hee Lee, Mi Young Lee, Ka-Ul Kim, Jeong Hyun Lee, Chi Hoon Park, Byung Ho Lee, and Kwang-Seok Oh | Biological and Pharmaceutical Bulletin2017, 40(9), 1454-1462 | 2017 | http://doi.org/10.1248/bpb.b17-00283 | ||
| 135 | Anti-cancer effect of novel PAK1 inhibitor via induction of PUMAmediated cell death and p21-mediated cell cycle arrest | Tae-Gyun Woo, Min-Ho Yoon, Shin-Deok Hong, Jiyun Choi, Nam-Chul Ha, Hokeun Sun, Bum-Joon Park | Oncotarget2017, 8(14), 23690-23701 | 2017 | http://dx.doi.org/10.18632/oncotarget.15783 | ||
| 136 | Naphthofuroquinone derivatives show strong antimycobacterial activities against drug-resistant Mycobacteria | Woong Sik Jang, Young-Sang Choi, Sukyung Kim, Md. Anirban Jyoti, Hoonhee Seo, Juhye Han, Yong-Sik Kim, Jiwon Lyu, Kung-Woo Nam, Byung-Eui Lee, Kee-In Lee & Ho-Yeon Song | Journal of Chemotherapy2017, 29(6), 338-343 | 2017 | http://dx.doi.org/10.1080/1120009X.2017.1296987 | ||
| 137 | On-Chip Peptide Mass Spectrometry Imaging for Protein Kinase Inhibitor Screening | Young-Lai Cho, Young-Pil Kim, Jin Gyeong Son, Miyoung Son, and Tae Geol Lee | Analytical Chemistry2017, 89, 799-806 | 2017 | http://dx.doi.org/10.1021/acs.analchem.6b03557 | ||
| 138 | Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression | Ah-Young Oh, Youn Sang Jung, Jiseon Kim, Jee-Hyun Lee, Jung-Hyun Cho, Ho-Young Chun, Soyoung Park, Hyunchul Park, Sikeun Lim, Nam-Chul Ha, Jong Sook Park, Choon-Sik Park, Gyu-Yong Song, and Bum-Joon Park | Cancer Research2016, 76(16), 4791-4804 | 2016 | http://dx.doi.org/10.1158/0008-5472.CAN-15-1025 | ||
| 139 | Dihydroergotamine Tartrate Induces Lung Cancer Cell Death through Apoptosis and Mitophagy | Chang S.-H., Lee A.Y., Yu K.-N., Park J., Kim K.P., Cho M.-H. | Chemotherapy2016, 61(6), 304-312 | 2016 | http://dx.doi.org/10.1159/000445044 | ||
| 140 | Minor modifications to ceritinib enhance anti-tumor activity in EML4-ALK positive cancer | Chung Hyo Kang, Eun-Young Kim, Hyoung Rae Kim, Chong Ock Lee, Heung Kyoung Lee, Hye Gwang Jeong, Sang Un Choi, Chang-Soo Yun, Jong Yeon Hwang, Joo-Youn Lee, You Hwa Son, Sunjoo Ahn, Byung Hoi Lee, Heejung Jung, Chi Hoon Park | Cancer Letters2016, 374, 272-278 | 2016 | http://dx.doi.org/10.1016/j.canlet.2016.02.009 | ||
| 141 | Novel 2,4-diaminopyrimidines bearing tetrahydronaphthalenyl moiety against anaplastic lymphoma kinase (ALK): Synthesis, in vitro, ex vivo, and in vivo efficacy studies | Dawn Song, Minji Lee, Chi Hoon Park, Sunjoo Ahn, Chang Soo Yun, Chong Ock Lee, Hyoung Rae Kim, Jong Yeon Hwang | Bioorganic & Medicinal Chemistry Letters2016, 26, 1720-1725 | 2016 | http://dx.doi.org/10.1016/j.bmcl.2016.02.052 | ||
| 142 | DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression | Dong Wha Jun, Mihwa Hwang, Yun-Hee Kim, Kyung-Tae Kim, Sunshin Kim and Chang-Hun Lee | Oncotarget2016 | 2016 | http://dx.doi.org/10.18632/oncotarget.7135 | ||
| 143 | Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain | Duk-Joong Kim, Chang-Ki Choi, Chan-Soo Lee, Mee-Hee Park, Xizhe Tian, Nam Doo Kim, Kee-In Lee, Joong-Kwon Choi, Jin Hee Ahn, Eun-Young Shin, Injae Shin and Eung-Gook Kim | Experimental & Molecular Medicine2016, 48, e229 | 2016 | http://dx.doi.org/10.1038/emm.2016.13 | ||
| 144 | A Dual Readout Assay Based on Fluorescence Polarization and Time-Resolved Fluorescence Resonance Energy Transfer to Screen for RSK1 Inhibitors | Eun-mi Jeong, Mi Young Lee, Jeong Hyun Lee, Byung Ho Lee, Kwang-Seok Oh | Biological and Pharmaceutical Bulletin (Japan)2016, 39, 547-555 | 2016 | http://dx.doi.org/10.1248/bpb.b15-00808 | ||
| 145 | Identification of novel protein tyrosine phosphatase sigma inhibitors promoting neurite extension | Hye Seon Lee, Bonsu Ku, Tae Hyun Park, Hwangseo Park, Joong-Kwon Choi, Kyu-Tae Chang, Cheol-Hee Kim, Seong Eon Ryu, Seung Jun Kim | Bioorganic & Medicinal Chemistry Letters2016, 26(1), 87-93 | 2016 | http://www.sciencedirect.com/science/article/pii/S0960894X15302341 | ||
| 146 | Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy | Hyun-Yi Kim, Sehee Choi, Ji-Hye Yoon, Hwan Jung Lim, Hyuk Lee, Jiwon Choi, Eun Ji Ro, Jung-Nyoung Heo, Weontae Lee, Kyoung Tai No & Kang-Yell Choi | EMBO Molecular Medicine2016 | 2016 | http://dx.doi.org/10.15252/emmm.201505714 | ||
| 147 | Development of potent chemical antituberculosis agents targeting Mycobacterium tuberculosis acetohydroxyacid synthase | In-Pil Jung, Na-Reum Ha, Sang-Choon Lee, Sung-Weon Ryoo, Moon-Young Yoon | International Journal of Antimicrobial Agents2016, 48, 247-258 | 2016 | http://dx.doi.org/10.1016/j.ijantimicag.2016.04.031 | ||
| 148 | Calcium-chelating alizarin and other anthraquinones inhibit biofilm formation and the hemolytic activity of Staphylococcus aureus | Jin-Hyung Lee, Yong-Guy Kim, Shi Yong Ryu, Jintae Lee | Scientific Reports2016, 1, 864 | 2016 | http://dx.doi.org/10.1038/srep19267 | ||
| 149 | IinQ attenuates systemic inflammatory responses via selectively impairing the Myddosome complex formation upon TLR4 ligation | Kidong Kang†, Minho Won†, Jae-Min Yuk†, Chan-Yong Park, Hee Sun Byun, Kyeong Ah Park, So-Ra Lee, Young-Goo Kang, Han-Ming Shen, Ill Young Lee, Gang Min Hur | Biochemical Pharmacology2016, 121, 52-66 | 2016 | http://dx.doi.org/10.1016/j.bcp.2016.09.017 | ||
| 150 | Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study | Minju Kim, Sunhoe Lee, Eun Beul Park, Kwang Jong Kim, Hwi Ho Lee, Ji-Sun Shin, Katrin Fischer, Andreas Koeberle, Oliver Werz, Kyung-Tae Lee, Jae Yeol Lee | Bioorganic & Medicinal Chemistry Letters2016, 26(1), 94-99 | 2016 | http://www.sciencedirect.com/science/article/pii/S0960894X1530233X | ||
| 151 | Chromo/Fluorogenic Detection of Co2+, Hg2+ and Cu2+ by the Simple Schiff Base Sensor | Muhammad Saleem, Chung Ho Khang, Moon-Hwan Kim, Ki Hwan Lee | Journal of Fluorescence – RAPID COMMUNICATION2016, 26(1), 11-22 | 2016 | http://link.springer.com/article/10.1007/s10895-015-1723-x | ||
| 152 | Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening | Myoung Eun Jung, Byung Jin Byun, Hye-Mi Kim, Joo Yun Lee, Jin-Hee Park, Nari Lee, You Hwa Son, Sang Un Choi, Kyung-Min Yang, Seong-Jin Kim, Kwangho Lee, Yong-Chul Kim, Gildon Choi | Bioorganic & Medicinal Chemistry Letters2016, 26(11), 2719-2723 | 2016 | http://dx.doi.org/10.1016/j.bmcl.2016.03.111 | ||
| 153 | Stereoselective synthesis of 1,3-disubstituted isoindolines via Rh(III)-catalyzed tandem oxidative olefination-cyclization of 4-aryl cyclic sulfamidates | Se-Mi Son, Yeon Ji Seo, and Hyeon-Kyu Lee | ChemComm2016, 52, 4286-4289 | 2016 | http://dx.doi.org/10.1039/c5cc09888b | ||
| 154 | Activity of novel inhibitors of Staphylococcus aureus biofilms | Seung-Gyun Woo, So-Yeon Lee, So-Min Lee, Kyoung-Hee Lim, Eun-Ju Ha, Yong-Bin Eom | Folia Microbiologica2016, 61, 1-11 | 2016 | http://dx.doi.org/10.1007/s12223-016-0485-4 | ||
| 155 | Urinary Bladder-Relaxant Effect of Kurarinone Depending on Potentiation of Large-Conductance Ca2+-Activated K+ Channels | Sojung Lee, Mee Ree Chae, Byoung-Cheol Lee, Yong-Chul Kim, Jae Sue Choi, Sung Won Lee, Jae Hoon Cheong, and Chul-Seung Park | Molecular Pharmacology2016, in press | 2016 | http://dx.doi.org/10.1124/mol.115.102939 | ||
| 156 | Interruption of progerin.lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype | Su-Jin Lee, Youn-Sang Jung, Min-Ho Yoon, So-mi Kang, Ah-Young Oh, Jee-Hyun Lee, So-Young Jun, Tae-Gyun Woo, Ho-Young Chun, Sang Kyum Kim, Kyu Jin Chung, Ho-Young Lee, Kyeong Lee, Guanghai Jin, Min-Kyun Na, Nam Chul Ha, Clea Barcena, Jose M.P. Freije, Carlos Lopez-Otin, Gyu Yong Song and Bum-Joon Park | Journal of Clinical Investigation2016, 126(10), 3879-3893 | 2016 | http://dx.doi.org/10.1172/JCI84164 | ||
| 157 | Novel 3-amino-7-(aminomethyl)-1H-indazol-4-ol as the PI3Kγ enzyme inhibitor | Sukumar Bepary, In Kwon Yoon, and Ge Hyeong Lee | Bulletin of the Korean Chemical Society2016, 37, 2054-2057 | 2016 | http://dx.doi.org/10.1002/bkcs.10994 | ||
| 158 | Peptide inhibition of p22phox and Rubicon interaction as a therapeutic strategy for septic shock | Ye-Ram Kim, Hyun-Jung Koh, Jae-Sung Kim, Jin-Seung Yun, Kiseok Jang, Joo-Youn Lee, Jae U. Jung, Chul-Su Yang | Biomaterials2016, 101, 47-59 | 2016 | http://dx.doi.org/10.1016/j.biomaterials.2016.05.046 | ||
| 159 | Diacetoxyscirpenol as a new anticancer agent to target hypoxiainducible factor 1 | Yong-Joon Choi, Hyun-Woo Shin, Yang-Sook Chun, Alain Simplice Leutou, Byeng Wha Son, Jong-Wan Park | Oncotarget2016, 7(38), 62107-62122 | 2016 | http://dx.doi.org/10.18632/oncotarget.11529 | ||
| 160 | Identification of Mitotic Blockers by Phenotypic Screening of a Clinical Compound Library | You Hwa Son, Chi Hoon Park, and Sang Un Choi | Bulletin of the Korean Chemical Society2016, 37, 1942-1946 | 2016 | http://dx.doi.org/10.1002/bkcs.10999 | ||
| 161 | Identification of a New Morpholine Scaffold as a P2Y12 Receptor Antagonist | Young Ha Ahn†, Joo-Youn Lee†, Hee Dong Park, Tae Hun Kim, Min Chul Park, Gildon Choi and Sunghoon Kim | Molecules2016, 21, 1114-1124 | 2016 | http://dx.doi.org/10.3390/molecules21091114 | ||
| 162 | Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection | Young Ha Ahn†, Sunyoung Park†, Jeong June Choi, Bo-Kyung Park, Kyung Hee Rhee, Eunjoo Kang, Soyeon Ahn, Chul-Ho Lee, Jong Soo Lee, Kyung-Soo Inn, Mi-La Cho, Sung-Hwan Park, Kyunghee Park, Hae Jung Park, Jae Hyun Lee, Jung Won Park, Nam Hoon Kwon, Hyunbo Shim, ByungWoo Han, Pilhan Kim, Joo-Youn Lee, Youngho Jeon, Jin Won Huh, Mirim Jin and Sunghoon Kim | Nature Microbiology2016, 2, 1-12 | 2016 | http://dx.doi.org/10.1038/NMICROBIOL.2016.191 | ||
| 163 | Selective and Efficient Elimination of Vibrio cholerae with a Chemical Modulator that Targets Glucose Metabolism | Young Taek Oh, Hwa Young Kim, Eun Jin Kim, Junhyeok Go, Wontae Hwang, Hyoung Rae Kim, Dong Wook Kim and Sang Sun Yoon | Frontiers in Cellular and Infection Microbiology2016, 6, 156 | 2016 | http://dx.doi.org/10.3389/fcimb.2016.00156 | ||
| 164 | Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor | Ga Ae Kang, Minji Lee, Dawn Song, Heung Kyoung Lee, Sunjoo Ahn, Chi Hoon Park, Chong Ock Lee, Chang Soo Yun, Heejung Jung, Pilho Kim, Jae Du Ha, Sung Yun Cho, Hyoung Rae Kim, Jong Yeon Hwang | Bioorganic & Medicinal Chemistry Letters2015, 25(18), 3992-3998 | 2015 | http://www.sciencedirect.com/science/article/pii/S0960894X15007088 | ||
| 165 | Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor | Hyeon Young Kim, Vithal B. Jadhav, Dae Young Jeong, Woo Kyu Park, Jong-Hwan Song, Sunkyung Lee, Heeyeong Cho | Archives of Pharmacal Research2015, 38, 1019-1032 | 2015 | http://link.springer.com/article/10.1007/s12272-015-0560-4 | ||
| 166 | Praeruptorin A Inhibits in Vitro Migration of Preosteoclasts and in Vivo Bone Erosion, Possibly Due to Its Potential To Target Calmodulin | Jeong-Tae Yeon, Sik-Won Choi, Byung Jun Ryu, Kwang-Jin Kim, Joo Yun Lee, Byung Jin Byun, Young-Jin Son and Seong Hwan Kim | Journal of Natural Products2015, 78, 776-782 | 2015 | http://pubs.acs.org/doi/abs/10.1021/np501017z | ||
| 167 | A lipophilic fluorescent LipidGreen1-based quantification method for high-throughput screening analysis of intracellular poly-3-hydroxybutyrate | Ji Eun Choi, Hye Young Na, Taek Ho Yang, Sung-Keun Rhee and Jae Kwang Song | AMB Express2015, 5, 482015, 5, 48 | 2015 | http://www.amb-express.com/content/5/1/48 | ||
| 168 | An indoxyl compound 5-bromo-4-chloro-3-indolyl 1,3-diacetate, CAC-0982, suppresses activation of Fyn kinase in mast cells and IgE-mediated allergic responses in mice | Jun Ho Lee, Tae Hyung Kim, Hyuk Soon Kim, A-Ram Kim, Do-Kyun kim, Seung Taek Nam, HyunWoo Kim, Young Hwan Park, Erk Her, Yeong Min Park, Hyung Sik Kim, Young Mi Kim, Wahn Soo Choi | Toxicology and Applied Pharmacology2015, 285(3), 179-186 | 2015 | http://www.sciencedirect.com/science/article/pii/S0041008X15001398 | ||
| 169 | Synthesis of 4-(3,4-dicarboxamido-1H-pyrrole)pyrimidines as Anaplastic Lymphoma Kinase Inhibitors | Muhammad Latif, Byung Jin Byun and Kwangho Lee | Bulletin of the Korean Chemical Society2015, 36(2), 520-525 | 2015 | https://onlinelibrary.wiley.com/doi/full/10.1002/bkcs.10097 | ||
| 170 | Design, Synthesis, and Evaluation of 2-Anilino-4-(3,5-dicarbox- amidespiperidine)-pyrimidines as Anaplastic Lymphoma Kinase Inhibitors | Muhammad Latif, Sangjun Park, Imran Ali, Hyeonjeong Choe, Chong Hak Chae, Chi Hoon Park, Hyoung Rae Kim, Chang-Soo Yun and Kwangho Lee | Bulletin of the Korean Chemical Society2015, 36(2), 2397-2400 | 2015 | http://onlinelibrary.wiley.com/doi/10.1002/bkcs.10454/abstract;jsessionid=6E868AC9024F2D91A18E2354099C25F1.f03t04 | ||
| 171 | Quinoline Compound KM11073 Enhances BMP-2-Dependent Osteogenic Differentiation of C2C12 Cells via Activation of p38 Signaling and Exhibits In Vivo Bone Forming Activity | Seung-hwa Baek, Sik-Won Choi, Sang-Joon Park, Sang-Han Lee, Hang-Suk Chun, Seong Hwan Kim | PLOS ONE2015, 10(3): e0120150 | 2015 | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120150 | ||
| 172 | Identification of a novel 11β-HSD1 inhibitor from a high-throughput screen of natural product extracts | Sung Bum Park, Ji Seon Park, Won Hoon Jung, AReum Park, Sae Rom Jo, Hee Youn Kim, Sang Dal Rhee, Shi Yong Ryu, Hye Gwang Jeong, Seongsoon Park, Hyuk Lee, Ki Young Kim | Pharmacological Research2015, 102, 245-253 | 2015 | http://www.sciencedirect.com/science/article/pii/S1043661815002571 | ||
| 173 | Stereoselective Synthesis of 4-Substituted Cyclic Sulfamidate-5-Phosphonates by Using Rh-Catalyzed, Asymmetric Transfer Hydrogenation with Accompanying Dynamic Kinetic Resolution | Yeon Ji Seo, Jin-ah Kim, and Hyeon-Kyu Lee | The Journal of Organic Chemistry2015, 80(17), 8887-8902 | 2015 | http://pubs.acs.org/doi/10.1021/acs.joc.5b01434 | ||
| 174 | Synthesis and anti-tubercular activity of 2-nitroimidazooxazines with modification at the C-7 position as PA-824 analogs | Young-Goo Kang, Chan-Yong Park, Hongsuk Shin, Ramandeep Singh, Garima Arora, Chan-mo Yu, Ill Young Lee | Bioorganic & Medicinal Chemistry Letters2015, 25(17), 3650-3653 | 2015 | http://www.sciencedirect.com/science/article/pii/S0960894X15006538 | ||
| 175 | Discovery and the structural basis of a novel p21-activated kinase 4 inhibitor | Byung Jun Ryu, Sunmin Kim, Bora Min, Keon Young Kim, Jin Soo Lee, Whui Jung Park, Hyuk Lee, Seong Hwan Kim, Sang Youn Park | Cancer Letters2014, 349(1), 45-50 | 2014 | https://doi.org/10.1016/j.canlet.2014.03.024 | ||
| 176 | 4-Substituted quinazoline derivatives as novel EphA2 receptor tyrosine kinase inhibitors | Chae Jo Lim, Kwang-Seok Oh, Jae Du Ha, Jeong Hyun Lee, Ho Won Seo, Chong Hack Chae, Dae-Ghon Kim, Mi-Jin Lee, Byung Ho Lee | Bioorganic & Medicinal Chemistry Letters2014, 24, 4080-4083 | 2014 | https://doi.org/10.1016/j.bmcl.2014.07.081 | ||
| 177 | Identification of a series of 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl) pyridin-2-amines, as a new class of G-protein-coupled receptor kinase 2 and 5 inhibitor | Cheon Ho Park, Mi Young Lee, Jeong Hyun Lee, Byung Ho Lee, Kwang-seok Oh | Receptors & Clinical Investigation2014, 1(4), 112-114 | 2014 | http://dx.doi.org/10.1172/JCI200524178 | ||
| 178 | Inhibition of STAT3 activation by KT-18618 via the disruption of the interaction between JAK3 and STAT3 | Dae-Seop Shin, Seung Nam Jung, Jieun Yun, Chang Woo Lee, Dong Cho Han, BumTae Kim, Yong Ki Min, Nam Sook Kang, Byoung-Mog Kwon | Biochemical Pharmacology2014, 89(1), 62-73 | 2014 | https://doi.org/10.1016/j.bcp.2014.02.017 | ||
| 179 | 6-Trifluoromethyl-2-thiouracil possesses anti-Toxoplasma gondii effect in vitro and in vivo with low hepatotoxicity | Hwa-Jung Choi, Seung-Taek Yu, Kee-In Lee, Joong-Kwon Choi, Bo-Yoon Chang, Sung-Yeon Kim, Mi-Hwa Ko, Hyun-Ok Song, Hyun Park | Experimental Parasitology2014, 143, 24-29 | 2014 | https://doi.org/10.1016/j.exppara.2014.05.002 | ||
| 180 | ALK inhibitors of bis-ortho-alkoxy-para-piperazinesubstituted-pyrimidines and -triazines for cancer treatment | Hyeon Ji Lee, Muhammad Latif, Hyeonjeong Choe, Imran Ali, Heung Kyoung Lee, Eun Hye Yang, Jeong In Yun, Chong Hak Chae, Jae-Kyung Jung, Hyoung Rae Kim, Chong Ock Lee, Chi Hoon Park, Kwangho Lee | Archives of Pharmacal Research2014 | 2014 | https://doi.org/10.1007/s12272-013-0323-z | ||
| 181 | 6-Methoxyflavone Inhibits NFAT Translocation into the Nucleus and Suppresses T Cell Activation | Jae-Seon So, Gi-Cheon Kim, Minkyung Song, Choong-Gu Lee, Eunbee Park, Ho Jin Kim, Young Sup Kim, Chang-Duk Jun and Sin-Hyeog Im | The Journal of Immunology2014, 193(6), 2772-2783 | 2014 | https://doi.org/10.4049/jimmunol.1400285 | ||
| 182 | Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors | Jimin Woo, Hyun-Young Kim, Byung Jin Byun, Chong-Hak Chae, Ji Young Lee, Shi Yong Ryu, Woo-Kyu Park, Heeyeong Cho, Gildon Choi | Bioorganic & Medicinal Chemistry Letters2014, 24(11), 2486-2492 | 2014 | https://doi.org/10.1016/j.bmcl.2014.04.010 | ||
| 183 | Stereoselective synthesis of 4-substituted-cyclic sulfamidate-5-carboxylates by asymmetric transfer hydrogenation accompanied by dynamic kinetic resolution and applications to concise stereoselective syntheses of (-)-epi-cytoxazone and the taxotere side-chain | Jin-ah Kim, Yeon Ji Seo, Soyeong Kang, Juae Han and Hyeon-Kyu Lee | Chem. Commun.2014, 50, 13706-13709 | 2014 | https://doi.org/10.1039/C4CC06395C | ||
| 184 | Coumarins reduce biofilm formation and the virulence ofEscherichia coli O157:H7 | Jin-Hyung Lee, Yong-Guy Kim, Hyun Seob Cho, Shi Yong Ryu, Moo Hwan Cho, Jintae Lee | Phytomedicine2014, 21, 1037-1042 | 2014 | https://doi.org/10.1016/j.phymed.2014.04.008 | ||
| 185 | Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli O157:H7 and Staphylococcus aureus biofilm formation | Jin-Hyung Lee, Yong-Guy Kim, Shi Yong Ryu, Moo Hwan Cho, Jintae Lee | International Journal of Food Microbiology2014, 174, 47-55 | 2014 | https://doi.org/10.1016/j.ijfoodmicro.2013.12.030 | ||
| 186 | Resveratrol Oligomers Inhibit Biofilm Formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa | Jin-Hyung Lee, Yong-Guy Kim, Shi Yong Ryu, Moo Hwan Cho, Jintae Lee | Journal of Natural Products2014, 77(1), 168-172 | 2014 | https://doi.org/10.1021/np400756g | ||
| 187 | Stilbenes Reduce Staphylococcus aureus Hemolysis, Biofilm Formation, and Virulence | Lee Kayeon, Lee Jin-Hyung, Ryu Shi Yong, Cho Moo Hwan, and Lee Jintae | Foodborne Pathogens and Disease2014, 11(9), 710-717 | 2014 | https://doi.org/10.1089/fpd.2014.1758 | ||
| 188 | Dynamic Kinetic Resolution Based Asymmetric Transfer Hydrogenation of α.Alkoxy-β-Ketophosphonates. Diastereo- and Enantioselective Synthesis of Monoprotected 1,2-Dihydroxyphosphonates | Se-Mi Son and Hyeon-Kyu Lee | The Journal of Organic Chemistry2014, 79, 2666-2681 | 2014 | https://doi.org/10.1021/jo500148j | ||
| 189 | Discovery of substituted 6-pheny-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitors | Seung-Tae Kang, Eun-Young Kim, Raghavendra Archary, Heejung Jung, Chi Hoon Park, Chang-Soo Yun, Jong Yeon Hwang, Sang Un Choi, Chonghak Chae, Chong Ock Lee, Hyoung Rae Kim, Jae Du Ha, Dohyun Ryu, Sung Yun Cho | Bioorganic & Medicinal Chemistry Letters2014, 24, 5093-5097 | 2014 | https://doi.org/10.1016/j.bmcl.2014.08.067 | ||
| 190 | Synthesis and anti-influenza virus activity of 4-oxo- or thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-ones | Ye Jin Jang, Raghavendra Achary, Hye Won Lee, Hyo Jin Lee, Chong-Kyo Lee, Soo Bong Han, Young-Sik Jung, Nam Sook Kang, Pilho Kim, Meehyein Kim | Antiviral Research2014, 107, 66-75 | 2014 | https://doi.org/10.1016/j.antiviral.2014.04.013 | ||
| 191 | Xanthene Derivatives Increase Glucose Utilization through Activation of LKB1-Dependent AMP-Activated Protein Kinase | Yonghoon Kwon, Parkyong Song, Jong Hyuk Yoon, Jaewang Ghim, Dayea Kim, Byungjun Kang, Taehoon G. Lee, Jin-Ah Kim, Joong-Kwon Choi, In Kwon Youn, Hyeon-Kyu Lee, Sung Ho Ryu | PLOS One2014, 9(9), e108771 | 2014 | https://doi.org/10.1371/journal.pone.0108771 | ||
| 192 | Novel bis-ortho-alkoxy-para-piperazinesubstituted-2, 4-dianilinopyrimidines (KRCA-0008) as potent and selective ALK inhibitors for anticancer treatment | Chi Hoon Park, Hyeonjeong Choe, In-Young Jang, So Yeong Kwon, Muhammad Latif, Heung Kyoung Lee, Hyeon Ji Lee, Eun Hye Yang, Jeong In Yun, Chong Hak Chae, Sung Yun Cho, Sang Un Choi, Jae Du Ha, Heejung Jung, Hyoung Rae Kim, Pilho Kim, Chong Ock Lee, Chang-Soo Yun, Kwangho Lee | Bioorganic & Medicinal Chemistry Letters2013, 23(22), 6192-6196 | 2013 | https://doi.org/10.1016/j.bmcl.2013.08.090 | ||
| 193 | Elicitation of Induced Resistance against Pectobacterium carotovorum and Pseudomonas syringae by Specific Individual Compounds Derived from Native Korean Plant Species | Geun Cheol Song, Shi Yong Ryu, Young Sup Kim, Ji Young Lee, Jung Sup Choi and Choong-Min Ryu | Molecules2013, 18, 12877-12895 | 2013 | https://doi.org/10.3390/molecules181012877 | ||
| 194 | Identification of Novel Irreversible Inhibitors of UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) from Haemophilus influenzae | Han SG, Lee WK, Jin BS, Lee KI, Lee HH, Yu YG | Journal of Microbiology Biotechnology2013, 23(3), 329-334 | 2013 | https://doi.org/10.4014/jmb.1210.10053 | ||
| 195 | Inhibition of Pseudomonas aeruginosa and Escherichia coli O157:H7 Biofilm Formation by Plant Metabolite ε-Viniferin | Hyun Seob Cho, Jin-Hyung Lee, Shi Yong Ryu, Sang Woo Joo, Moo Hwan Cho, and Jintae Lee | Journal of Agricultural and Food Chemistry2013, 61(29), 7120-7126 | 2013 | https://doi.org/10.1021/jf4009313 | ||
| 196 | Biochemical characterization and evaluation of potent inhibitors of the Pseudomonas aeruginosa PA01 acetohydroxyacid synthase | June-Haeng Cho, Mi-Young Lee, Irshad Ahmed Baig, Na-Reum Ha, Joungmok Kim, Moon-Young Yoon | Biochimie2013, 1-11 | 2013 | https://doi.org/10.1016/j.biochi.2013.03.007 | ||
| 197 | Discovery of Novel Scaffolds for Rho Kinase 2 Inhibitor Through TRFRET- Based High Throughput Screening Assay | Kwang-Seok Oh, Jihye Mun, Jae Eun Cho, Sunghou Lee, Kyu Yang Yi, Chae Jo Lim, Jin Soo Lee, Whui Jung Park and Byung Ho Lee | Combinatorial Chemistry & High Throughput Screening2013, 16(1), 37-46 | 2013 | https://doi.org/10.2174/1386207311316010006 | ||
| 198 | Inhibition of influenza virus internalization by (-)-epigallocatechin-3-gallate | Meehyein Kim, So-Yeon Kim, Hye Won Lee, Jin Soo Shin, Pilho Kim, Young-Sik Jung, Hyeong-Seop Jeong, Jae-Kyung Hyun, Chong-Kyo Lee | Antiviral Research2013, 100, 460-472 | 2013 | https://doi.org/10.1016/j.antiviral.2013.08.002 | ||
| 199 | New Natural Herbicide Candidate for Sicyon angulatus Control | New Natural Herbicide Candidate for Sicyon angulatus Control | INTECH2013, chapter 12 | 2013 | https://doi.org/10.5772/54964 | ||
| 200 | Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors | Sung Yun Cho, Byung Ho Lee, Heejung Jung, Chang Soo Yun, Jae Du Ha, Hyoung Rae Kim, Chong Hak Chae, Jeong Hyun Lee, Ho Won Seo, Kwang-Seok Oh | Journal of Agricultural and Food Chemistry2013, 23(24), 6711-6716 | 2013 | https://doi.org/10.1016/j.bmcl.2013.10.036 | ||
| 201 | In silico identification of poly(ADP-ribose)polymerase-1 inhibitors and their chemosensitizing effects against cisplatin-resistant human gastric cancer cells | Tuong Vy Thi Le, Jee Hee Suh, Nakjeong Kim, Hyun-Ju Park | Bioorganic & Medicinal Chemistry Letters2013, 23(9), 2642-2646 | 2013 | https://doi.org/10.1016/j.bmcl.2013.02.094 | ||
| 202 | Efficient synthesis of 3H,3’H-spiro[benzofuran-2,1′-isobenzofuran]-3,3′-dione as novel skeletons specifically for influenza virus type B inhibition | Yashwardhan Malpani, Raghavendra Achary, So Yeon Kim, Hee Chun Jeong, Pilho Kim, Soo Bong Han, Meehyein Kim,, Chong-Kyo Lee, Jae Nyoung Kim, Young-Sik Jung | European Journal of Medicinal Chemistry2013, 62, 534-544 | 2013 | https://doi.org/10.1016/j.ejmech.2013.01.015 | ||
| 203 | Characterization of DDRI-18 (3,3′-(1H,3′H-5,5′-bibenzo[d]imidazole-2,2′-diyl)dianiline), a novel small molecule inhibitor modulating the DNA damage response | DW Jun, YS Jeong, HJ Kim, K-C Jeong, S Kim, C-H Lee | British Journal of Pharmacology2012, 167(1), 141-150 | 2012 | https://doi.org/10.1111/j.1476-5381.2012.01977.x | ||
| 204 | Proteolytic assay-based screening identifies a potent inhibitor of anthrax lethal factor | Hae-Chul Park, So-Ra Sung, Su Min Lim, Jong-Sun Lee, Sung-Kun Kim, Moon-Young Yoon | Microbial Pathogenesis2012, 53, 109-112 | 2012 | https://doi.org/10.1016/j.micpath.2012.04.004 | ||
| 205 | Identification and characterization of triamcinolone acetonide, a microglial-activation inhibitor | Jinpyo Hong, Bo-Kyong Kim, Hyoungsub Lim, Soojin Lee, Sung Joong Lee | Immunopharmacology and Immunotoxicology2012, 34(6), 912-918 | 2012 | https://doi.org/10.3109/08923973.2012.671332 | ||
| 206 | Plumbagin as a new natural herbicide candidate for Sicyon angulatus control agent with the target 8-amino-7-oxononanoate synthase | Jung-Sup Choi, No-Joong Park, Hee-Kyung Lim, Young-Kwan Ko, Young-Sup Kim, Shi-Yong Ryu, In-Taek Hwang | Pesticide Biochemistry and Physiology2012, 103, 166-172 | 2012 | https://doi.org/10.1016/j.pestbp.2012.04.007 | ||
| 207 | Inhibitory Effect of 4-Aryl 2-Substituted Aniline-thiazole Analogs on Growth of Human Prostate Cancer LNCap Cells | Seung-hwa Baek, Nakjeong Kim, Seong Hwan Kim, Kwang Hwa Park, Kyung-Chae Jeong, Bae Keun Park and Nam Sook Kang | Bulletin of the Korean Chemical Society2012, 33(1), 111-114 | 2012 | https://doi.org/10.5012/bkcs.2012.33.1.111 | ||
| 208 | A compound(DW1182v) protecting high glucose/palmitate-induced glucolipotoxicity to INS-1 beta cells preserves islet integrity and improves hyperglycemia in obese db/db mouse | Soo-Jin Lee, Sung-E Choi, Yun Cheong Hwang, Ik-Rak Jung, Sang-A Yi, Jong Gab Jung, Jin-Mo Ku, Kwiwan Jeoung, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Kwan-Woo Lee, Yup Kang | European Journal of Pharmacology2012, 696(1-3), 187-193 | 2012 | https://doi.org/10.1016/j.ejphar.2012.09.023 | ||
| 209 | Identification of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one derivatives as inhibitors of the phosphatase SerB653 in Porphyromonas gingivalis, implicated in periodontitis | Suk-Kyeong Jung, Youngkyung Ko, Keum Ran Yu, Ju Hee Kim, Joo-Youn Lee, Chong Hak Chae, Suk Ji, Chang Hyen Kim, Hyeon Kyu Lee, Eun Bok Choi, Bo Yeon Kim, Raymond L. Erikson, Sang J. Chung, Seung Jun Kim | Bioorganic and Medicinal Chemistry Letters2012, 22(5), 2084-2088 | 2012 | https://doi.org/10.1016/j.bmcl.2012.01.011 | ||
| 210 | Identification of novel mPGES-1 inhibitors through screening of a chemical library | Sung-Jun Park, Seong-Gu Han, Hafiz Muhammad Ahsan, Kijae Lee, Jae Yeol Lee, Ji-Sun Shin, Kyung-Tae Lee, Nam-Suk Kang, Yeon Gyu Yu | Bioorganic & Medicinal Chemistry Letters2012, 22, 7335-7339 | 2012 | https://doi.org/10.1016/j.bmcl.2012.10.085 | ||
| 211 | Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus | Suresh Thareja, Saurabh Aggarwal, T. R. Bhardwaj, Manoj Kumar | Medicinal Research Reviews2012, 32(3), 459-517 | 2012 | https://doi.org/10.1002/med.20219 | ||
| 212 | Structure-Activity Relationships and Optimization of 3,5-Dichloropyridine Derivatives As Novel P2X7 Receptor Antagonists | Won-Gil Lee, So-Deok Lee, Joong-Heui Cho, Younghwan Jung, Jeong-hyun Kim, Tran T. Hien, Keon-Wook Kang, Hyojin Ko, and Yong-Chul Kim | Journal of Medicinal Chemistry2012, 55, 3687-3698 | 2012 | https://doi.org/10.1021/jm2012326 | ||
| 213 | An In Vivo C. elegans Model System for Screening EGFR-Inhibiting Anti-Cancer Drugs | Young-Ki Bae, Jee Young Sung, Yong-Nyun Kim, Sunshin Kim, Kyeong Man Hong, Heung Tae Kim, Min Sung Choi, Jae Young Kwon, Jaegal Shim | PLoS ONE2012, 7(9), e42441 | 2012 | https://doi.org/10.1371/journal.pone.0042441 | ||
| 214 | Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer | Akira Ooki, Keishi Yamashita, Shiro Kikuchi, Shinichi Sakuramoto, Natsuya Katada, Mina Waraya, Hiroshi Kawamata, Hiroshi Nishimiya, Kazunori Nakamura and Masahiko Watanabe | BMC Cancer2011, 11, 122 | 2011 | https://doi.org/10.1186/1471-2407-11-122 | ||
| 215 | High-Throughput Methods in Identification of Protein Tyrosine Phosphatase Inhibitors and Activators | Elina Mattila and Johanna Ivaska | Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry – Anti-Cancer Agents)2011, 11(1), 141-150 | 2011 | https://doi.org/10.2174/187152011794941235 | ||
| 216 | Chemical compound 31002 stimulates cardiomyogenic differentiation of embryonic stem cells | Eun Kyoung Kim, Mi-Young Son, Youngkuk Kang, Chang-Hee Lee, Hae Rim Kim, Youngsuk Won, Wonkee Yoon, Hyoung-Chin Kim, and Ki-Hoan Nam | Lab Anim Res2011, 27(3), 205-212 | 2011 | https://doi.org/10.5625/lar.2011.27.3.205 | ||
| 217 | Development and Comparison of Whole-Cell Assay Systems for Quorum-Sensing Inhibitors Based on TraR, LasR, and QscR | Hai-Bo Liu, Jung Sun Kim and Sunghoon Park | Journal of Biomolecular Screening2011, 16(9), 986-994 | 2011 | https://doi.org/10.1177/1087057111416656 | ||
| 218 | Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery | Hyun Uk Kim, Soo Young Kim, Haeyoung Jeong, Tae Yong Kim, Jae Jong Kim, Hyon E Choy, Kyu Yang Yi, Joon Haeng Rhee, Sang Yup Lee | Molecular Systems Biology2011, 460, 1-15 | 2011 | https://doi.org/10.1038/msb.2010.115 | ||
| 219 | Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging | Jae Hong Lee, Ju-Hoon So, Jong Hyun Jeon, Eun Bok Choi, Yu-Ri Lee, Young-Tae Chang, Cheol-Hee Kim, Myung Ae Bae and Jin Hee Ahn | Chemical Communications2011, 47(26), 7500-7502 | 2011 | https://doi.org/10.1039/C1CC11253H | ||
| 220 | Selective Killing of Bacterial Persisters by a Single Chemical Compound without Affecting Normal Antibiotic-Sensitive Cells | Jun-Seob Kim, Paul Heo, Tae-Jun Yang, Ki-Sing Lee, Da-Hyeong Cho, Bum Tae Kim, Ji-Hee Suh, Hee-Jong Lim, Dongwoo Shin, Sung-Koo Kim, and Dae-Hyuk Kweon | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY2011, 55(11), 5380-5383 | 2011 | https://doi.org/10.1128/AAC.00708-11 | ||
| 221 | 4-Chlorotetrazolo[1,5-a]quinoxaline inhibits activation of Syk kinase to suppress mast cells in vitro and mast cell-mediated passive cutaneous anaphylaxis in mice | Kui Lea Park, Na Young Ko, Jun Ho Lee, Do Kyun Kim, Hyuk Soon Kim, A-Ram Kim, Erk Her, Bokyung Kim, Hyung Sik Kim, Eun-Yi Moon, Young Mi Kim, Hang-Rae Kim, Wahn Soo Choi | Toxicology and Applied Pharmacology2011, 257, 235-241 | 2011 | https://doi.org/10.1016/j.taap.2011.09.009 | ||
| 222 | Novel PPARgamma partial agonists with weak activity and no cytotoxicity; identified by a simple PPARgamma ligand screening system | Min-Chul Cho, Dong-Hun Lee, Eun Jin Kim, Jee-young Lee, Jeong-Woo Kang, Jong Hwan Song, Youhoon Chong, Yangmi Kim, Jin-Tae Hong, Do-Young Yoon | Molecular and Cellular Biochemistry2011, 358, 75-83 | 2011 | https://doi.org/10.1007/s11010-011-0923-1 | ||
| 223 | Development of a High-Content Screening Method for Chemicals Modulating DNA Damage Response | Sunshin Kim, Dong Hwa Jun, Hye Jin Kim, Kyung-Chae Jeong, Chang-Hun Lee | Journal of Biomolecular Screening2011, 16(2), 259-265 | 2011 | https://doi.org/10.1177/1087057110392993 | ||
| 224 | KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to the hsp70 Promoter | Young Ju Yoon, Joo Ae Kim, Ki Deok Shin, Dae-Seop Shin, Young Min Han, Yu Jin Lee, Jin Soo Lee, Byoung-Mog Kwon, and Dong Cho Han | The Journal of Biological Chemistry2011, 286(3), 1737-1747 | 2011 | https://doi.org/10.1074/jbc.M110.179440 | ||
| 225 | Inhibitors of the Pseudomonas aeruginosa quorum-sensing regulator, QscR | Hai-Bo Liu, Joon-Hee Lee, Jung Sun Kim and Sunghoon Park | Biotechnology and Bioengineering2010, 106(1), 119-126 | 2010 | https://doi.org/10.1002/bit.22672 | ||
| 226 | Autophagonizer, a novel synthetic small molecule, induces autophagic cell death | In-Kwon Choi, Yoon Sun Cho, Hye Jin Jung, Ho Jeong Kwon | Biochemical and Biophysical Research Communications2010, 393, 849-854 | 2010 | https://doi.org/10.1016/j.bbrc.2010.02.097 | ||
| 227 | Anti-inflammatory effects of synthetic compound KT-14480 in lipopolysaccharide-stimulated microglia cells | Jiyeon Ock, Kyoungho Suk | Journal of Pharmacy and Pharmacology2010, 62(2), 279-285 | 2010 | https://doi.org/10.1211/jpp.62.02.0017 | ||
| 228 | A novel anti-neuroinflammatory pyridylimidazole compound KR-31360 | Jiyeon Ock, Sangseop Kim, Kyu-Yang Yi, Nak-Jung Kim, Hyung Soo Han, Je-Yoel Cho, Kyoungho Suk | Biochemical Pharmacology2010, 79, 596-609 | 2010 | https://doi.org/10.1016/j.bcp.2009.09.026 | ||
| 229 | Identification of KT-15073 as an Inhibitor of Lipopolysaccharide-Induced Microglial Activation | Jiyeon Ock, Su Hyung Hong, Kyoungho Suk | Biological and Pharmaceutical Bulletin2010, 33(3), 461-467 | 2010 | https://doi.org/10.1248/bpb.33.461 | ||
| 230 | Identification of an ABCB/P-glycoprotein-specific Inhibitor of Auxin Transport by Chemical Genomics | Jun-Young Kim, Sina Henrichs, Aurelien Bailly, Vincent Vincenzetti, Valpuri Sovero, Stefano Mancuso, Stephan Pollmann, Daehwang Kim, Markus Geisler,and Hong-Gil Nam | The Journal of Biological Chemistry2010, 285(30), 23309-23317 | 2010 | https://doi.org/10.1074/jbc.M110.105981 | ||
| 231 | Identification of gp96 as a Novel Target for Treatment of Autoimmune Disease in Mice | Jung Min Han, Nam Hoon Kwon, Jin Young Lee, Seung Jae Jeong, Hee Jung Jung, Hyeong Rae Kim, Zihai Li, Sunghoon Kim | PLoS ONE2010, 5(3), e9792 | 2010 | https://doi.org/10.1371/journal.pone.0009792 | ||
| 232 | Identification of Novel Scaffolds for IkB Kinase Beta Inhibitor via a High Throughput Screening TR-FRET Assay | Kwang-Seok Oh, Sunghou Lee, Joong Kwon Choi and Byung Ho Lee | Combinatorial Chemistry & High Throughput Screening2010, 13, 790-797 | 2010 | https://doi.org/10.2174/138620710792927367 | ||
| 233 | Small-molecule inhibitors of c-Myc transcriptional factor suppress proliferation and induce apoptosis of promyelocytic leukemia cell via cell cycle arrest | Kyung-Chae Jeong,Kyung-Ohk Ahn and Chul-Hak Yang | Molecular BioSystems2010, 6(8), 1503-1509 | 2010 | https://doi.org/10.1039/c002534h | ||
| 234 | Characterization of Acetohydroxyacid Synthesis I from Escherichia coli K-12 and Identification of Its Inhibitors | Pham Ngoc Chien, Ji-Young Moon, Jun-Haeng Cho, Soo-Jae Lee, Joon-Shik Park, Dong-Eun Kim, Yoonkyung Park, and Moon-Young Yoon | Biosci. Biotechnol. Biochem2010, 74(11), 2281-2286 | 2010 | https://chembank.org/%ed%99%9c%ec%9a%a9%eb%85%bc%eb%ac%b8/%E2%80%A2%20https://doi.org/10.1271/bbb.100496 | ||
| 235 | Discovery of cyclicsulfonamide derivatives as 11b-hydroxysteroid dehydrogenase 1 inhibitors | Se Hoan Kim, Ravirala Ramu, Sung Wook Kwon, Su-Hee Lee, Chi Hyun Kim, Seung Kyu Kang, Sang Dal Rhee, Myung Ae Bae, Sung Hoon Ahn, Duck Chan Ha, Hyae Gyeong Cheon, Ki Young Kim, Jin Hee Ahn | Bioorganic & Medicinal Chemistry Letters2010, 20, 1065-1069 | 2010 | https://doi.org/10.1016/j.bmcl.2009.12.035 | ||
| 236 | Individual and common inhibitors of coronavirus and picornavirus main proteases | Chih-Jung Kuo, Hun-Ge Liu, Yueh-Kuei Lo, Churl-Min Seong, Kee-In Lee, Young-Sik Jung, Po-Huang Liang | FEBS Letters2009, 583, 549-555 | 2009 | https://doi.org/10.1016/j.febslet.2008.12.059 | ||
| 237 | Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity | Da-Hye Kang, Kyu-Yeon Jun, Jin Pyo Lee, Chwang Siek Pak, Younghwa Na, and Youngjoo Kwon | Journal of Medicinal Chemistry2009, 52(9), 3093-3097 | 2009 | https://doi.org/10.1021/jm8014734 | ||
| 238 | Synthesis and structure?activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists | Ga Eun Lee, Ho-Sung Lee, So Deok Lee, Jung-Ho Kim, Won-Ki Kim, Yong-Chul Kim | Bioorganic & Medicinal Chemistry Letters2009, 19, 954-958 | 2009 | https://doi.org/10.1016/j.bmcl.2008.11.088 | ||
| 239 | Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening | Hendra Gunosewoyo, Mark J. Coster, Maxwell R. Bennett, Michael Kassiou | Bioorganic & Medicinal Chemistry2009, 17, 4861-4865 | 2009 | https://doi.org/10.1016/j.bmc.2009.05.083 | ||
| 240 | Modulation of Osteocalcin Expression by Purmorphamine Derivatives | Hye-Ryun Kim, So-Hee Jeong, Young-Sam Im, Sung Yun Cho, Joong-Kwon Choi, Hea Kyeong Shin, Yong-Min Kim, Jin-Ook Song, Seong-Ho Jeon and Joong-Kook Choi | GENES & GENOMICS2009, 31(3), 261-266 | 2009 | https://doi.org/10.1007/BF03191198 | ||
| 241 | Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells | Jiyeon Ock, Sangseop Kim, Kyoungho Suk | Pharmacological Research2009, 59(6), 414-422 | 2009 | https://doi.org/10.1016/j.phrs.2009.02.008 | ||
| 242 | Induction of neurogenesis in rat bone marrow mesenchymal stem cells using purine structure-based compounds | Mi Hee Cho, Jung Hwa Lee, Hyun Hee Ahn, Ju Young Lee, E Sle Kim, Yun Mi Kang, Byoung Hyun Min, Jae Ho Kim, Hai Bang Lee and Moon Suk Kim | Molecular BioSystems2009, 5, 609-611 | 2009 | https://doi.org/10.1039/B905598N | ||
| 243 | Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA | Min-Ju Chae, Hye Youn Sung, Eun-Hye Kim, Mira Lee, Hojoong Kwak, Chong Hak Chae, Sunwoo Kim and Woong-Yang Park | EXPERIMENTAL and MOLECULAR MEDICINE2009, 41(11), 824-831 | 2009 | https://doi.org/10.3858/emm.2009.41.11.088 | ||
| 244 | Identification of Osteogenic Purmorphamine Derivatives | Sung-Jin Lee; Hak-Kyo Lee; Sung Yun Cho; Joong-Kwon Choi; Hea Kyeong Shin; Eun-Jung Kwak; Mi-Ran Cho; Hye-Ryun Kim; Seung-Ryol Kim; Yong-Min Kim; Kyoung-Jin Park; Joong-Kook Choi | Molecules & Cells2008, 26(4), 380-386 | 2008 | http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&i=0578320080260040380&m=VIEW | ||
| 245 | Identification of the catalytic subunit of acetohydroxyacid synthase in Haemophilus influenzae and its potent inhibitors | Kyoung-Jae Choi, Kyoung Mi Noh, Dong-Eun Kim, Byung Hak Ha, Eunice Eunkyung Kim, Moon-Young Yoon | Archives of Biochemistry and Biophysics2007, 466, 24-30 | 2007 | https://doi.org/10.1016/j.abb.2007.07.011 | ||
| 246 | What’s new on CDC25 phosphatase inhibitors | Marie-Odile Contour-Galcera, Alban Sidhu, Gregoire Prevost, Dennis Bigg, Bernard Ducommun | Pharmacology & Therapeutics2007, 115, 1-12 | 2007 | https://doi.org/10.1016/j.pharmthera.2007.03.009 | ||
| 247 | [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs | Yong Joo Na, Heung Su Baek, Soo Mi Ahn, Hyun Jung Shin, Ih-Seop Chang, Jae Sung Hwang | Biochemical Pharmacology2007, 74, 780-786 | 2007 | https://doi.org/10.1016/j.bcp.2007.05.028 | ||
| 248 | Indenone Derivatives: A Novel Template for Peroxisome Proliferator-Activated Receptor γ (PPARγ) Agonists | Jin Hee Ahn, Mi Sik Shin, Sun Ho Jung, Seung Kyu Kang, Kwang Rok Kim, Sang Dal Rhee, Won Hoon Jung, Sung Don Yang, Seung Jun Kim, Joo Rang Woo, Jeong Hyung Lee, Hyae Gyeong Cheon and Sung Soo Kim | Journal of Medicinal Chemistry2006, 49, 4781-4784 | 2006 | https://doi.org/10.1021/jm060389m | ||
| 249 | Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors | Jin Hee Ahn, Seung Jun Kim, Woul Seong Park, Sung Yun Cho, Jae Du Ha, Sung Soo Kim, Seung Kyu Kang, Dae Gwin Jeong, Suk-Kyeong Jung, Sang-Hyeup Lee, Hwan Mook Kim, Song Kyu Park, Ki Ho Lee, Chang Woo Lee, Seong Eon Ryu and Joong-Kwon Choi | Bioorganic & Medicinal Chemistry Letters2006, 16, 2996-2999 | 2006 | https://doi.org/10.1016/j.bmcl.2006.02.060 | ||
| 250 | Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt | Jong Hee Ko, Seung Woo Yeon, Jung Su Ryu, Tae-Yong Kim, Eun-Ha Song, Hea-Jung You, Rae-Eun Park and Chung-Kyu Ryu | Bioorganic & Medicinal Chemistry Letters2006, 16, 6001-6005 | 2006 | https://doi.org/10.1016/j.bmcl.2006.08.120 | ||
| 251 | PTP-1B inhibitors: Cyclopenta[d][1,2]-oxazine derivatives | Sung Yun Cho, Ji Yoen Baek, Sang Sub Han, Seung Kyu Kang, Jae Du Ha, Jin Hee Ahn, Jae Don Lee, Kwang Rok Kim, Hyae Gyeong Cheon, Sang Dal Rhee, Sung Don Yang, Gyu Hwan Yon, Chwang Siek Pak and Joong-Kwon Choi | Bioorganic & Medicinal Chemistry Letters2006, 16, 499-502 | 2006 | https://doi.org/10.1016/j.bmcl.2005.10.062 | ||
| 252 | Development of a time-resolved fluorometric assay for the high throughput screening of melanin concentrating hormone receptor antagonists | Sunghou Lee, Gun-Do Kim, Woo-Kyu Park, Heeyeong Cho, Byung Ho Lee, Sung-eun Yoo, Jae Yang Kong | Journal of Pharmacological and Toxicological Methods2006, 53, 242-247 | 2006 | https://doi.org/10.1016/j.vascn.2005.09.001 | ||
| 253 | Inhibition of dipeptidyl peptidase IV by novel inhibitors with pyrazolidine scaffold | Hyae Gyeong Cheon, Sung-Soo Kim, Kwang-Rok Kim, Sang-Dal Rhee, Sung-Don Yang, Jin Hee Ahn, Sung-Dae Park, Jae Mok Lee, Won Hoon Jung, Hye Sook Lee, Hee Youn Kim | Biochemical Pharmacology2005, 70, 22-29 | 2005 | https://doi.org/10.1016/j.bcp.2005.04.004 | ||
| 254 | Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors | Jin Hee Ahn, Jin Ah Kim, Hye-Min Kim, Hyuk-Man Kwon, Sun-Chul Huh, Sang Dal Rhee, Kwang Rok Kim, Sung-Don Yang, Sung-Dae Park ,Jae Mok Lee, Sung Soo Kim and Hyae Gyeong Cheon | Bioorganic & Medicinal Chemistry Letters2005, 15, 1337-1340 | 2005 | https://doi.org/10.1016/j.bmcl.2005.01.020 | ||
| 255 | Pyrazolidine Derivatives with Heteroaryl Urea as Dipeptidyl Peptidase IV Inhibitors | Jin Hee AHN, Sun Ho JUNG, Jin Ah KIM, Seog Beom SONG, Soon Ji KWON, Kwang Rok KIM, Sang Dal RHEE, Sung-Dae PARK, Jae Mok LEE, Sung Soo KIM, and Hyae Gyeong CHEON | Chem. Pharm. Bull2005, 53(8), 1048-1050 | 2005 | https://doi.org/10.1248/cpb.53.1048 | ||
| 256 | Blocking Tumor Cell Migration and Invasion with Biphenyl Isoxazole Derivative KRIBB3, a Synthetic Molecule That Inhibits Hsp27 Phosphorylation | Ki Deok Shin, Mi-Young Lee, Dae-Seop Shin, Sangku Lee, Kwang-Hee Son, Sukhoon Koh, Young-Ki Paik, Byoung-Mog Kwon, and Dong Cho Han | The Journal of Biological Chemistry2005, 280(50), 41439-41448 | 2005 | https://doi.org/10.1074/jbc.M507209200 | ||
| 257 | EK-6136 (3-methyl-4-(O-methyl-oximino)-1-phenylpyrazolin-5-one): A novel Cdc25B inhibitor with antiproliferative activity | Kim, Kwang-Rok; Kwon, Ju-Lee; Kim, Ji-Sun; No, Zaesung; Kim, Hyoung Rae; Cheon, Hyae Gyeong | European Journal of Pharmacology2005, 528(1-3), 37-42 | 2005 | https://doi.org/10.1016/j.ejphar.2005.10.027 | ||
| 258 | EK-6136 (3-methyl-4-(O-methyl-oximino)-1-phenylpyrazolin-5-one): A novel Cdc25B inhibitor with antiproliferative activity | Kwang-Rok Kim, Ju-Lee Kwon, Ji-Sun Kim, Zaesung No, Hyoung Rae Kim, Hyae Gyeong Cheon | European Journal of Pharmacology2005, 528, 37-42 | 2005 | https://doi.org/10.1016/j.ejphar.2005.10.027 | ||
| 259 | KR-62436, 6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile, is a novel dipeptidyl peptidase-IV (DPP-IV) inhibitor with anti-hyperglycemic activity | Kwang-Rok Kim, Sang-Dal Rhee, Hee Youn Kim, Won Hoon Jung, Sung-Don Yang, Sung Soo Kim, Jin Hee Ahn, Hyae Gyeong Cheon | European Journal of Pharmacology2005, 518, 63-70 | 2005 | https://doi.org/10.1016/j.ejphar.2005.05.030 | ||
| 260 | (E)-Phenyl- and -heteroaryl-substituted O-benzoyl- (or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors | Tae-Sook Jeong, Mi Jeong Kim, Hana Yu, Kyung Soon Kim, Joong-Kwon Choi, Sung-Soo Kim and Woo Song Lee | Bioorganic & Medicinal Chemistry Letters2005, 15, 1525-1527 | 2005 | https://doi.org/10.1016/j.bmcl.2004.11.063 | ||
| 261 | Position of Pro and Ser near Glu7.32 in the Extracellular Loop 3 of Mammalian and Nonmammalian Gonadotropin-Releasing Hormone (GnRH) Receptors Is a Critical Determinant for Differential Ligand Selectivity for Mammalian GnRH and Chicken GnRH-II | CHENGBING WANG, OIM YUN, KAUSHIK MAITI, DA YOUNG OH, KYEONG KYU KIM, CHONG HAK CHAE, CHANG JUN LEE, JAE YOUNG SEONG, AND HYUK BANG KWON | Molecular Endocrinology2004, 18(1), 105-116 | 2004 | https://doi.org/10.1210/me.2003-0101 | ||
| 262 | Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent | Cheon, Hyae Gyeong; Kim, Sun-Mee; Yang, Sung-Don; Ha, Jae Du; Choi, Joong-Kwon | European Journal of Pharmacology2004, 485(1-3), 333-340 | 2004 | https://doi.org/10.1016/j.ejphar.2003.11.070 | ||
| 263 | Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent | Hyae Gyeong Cheon, Sun-Mee Kim, Sung-Don Yang, Jae Du Ha, Joong-Kwon Choi | European Journal of Pharmacology2004, 485, 333- 339 | 2004 | https://doi.org/10.1016/j.ejphar.2003.11.070 | ||
| 264 | Lead discovery of quinoxalinediones as an inhibitor of dipeptidyl peptidase-IV (DPP-IV) by high-throughput screening | Hyae-Gyeong Cheon, Chul-Min Lee, Beom-Tae Kim and Ki-Jun Hwang | Bioorganic & Medicinal Chemistry Letters2004, 14, 2661-2664 | 2004 | https://doi.org/10.1016/j.bmcl.2004.02.065 | ||
| 265 | Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents | Jin Hee Ahn, Hye-Min Kim, Sun Ho Jung, Seung Kyu Kang, Kwang Rok Kim, Sang Dal Rhee, Sung-Don Yang, Hyae Gyeong Cheon and Sung Soo Kim | Bioorganic & Medicinal Chemistry Letters2004, 14, 4461-4465 | 2004 | https://doi.org/10.1016/j.bmcl.2004.06.046 | ||
| 266 | Protein Tyrosine Phosphatase 1B Inhibitors: Catechols | Jin Hee Ahn, Sung Yun Cho, Jae Du Ha, Seung Kyu Kang, Sun Ho Jung, Hye-Min Kim, Sung Soo Kim, Kwang Rok Kim, Hyae Gyeong Cheon, Sung-Don Yang, and Joong-Kwon Choi | Bulletin of the Korean Chemical Society2003, 24(10), 1505-1508 | 2003 | https://doi.org/10.5012/bkcs.2003.24.10.1505 | ||
| 267 | Protein Tyrosine Phosphatase 1B Inhibitors: Heterocyclic Carboxylic Acids | Sung Yun Cho, Jin Hee Ahn, Jae Du Ha, Seung Kyu Kang, Ji Yoen Baek, Sang Sub Han, Eun Young Shin, Sung Soo Kim, Kwang Rok Kim, Hyae Gyeong Cheon, and Joong-Kwon Choi | Bulletin of the Korean Chemical Society2003, 24(10), 1455-1464 | 2003 | https://doi.org/10.5012/bkcs.2003.24.10.1455 | ||
| 268 | Design, Syntheses and Biological Evaluations of Nonpeptidic Caspase 3 Inhibitors | Eun-sook Kim, Sung-eun Yoo, Kyu Yang Yi, Sunkyung Lee, Jae-sung Noh, Yong-Sam Jung, Eunhee Kim, and Nakcheol Jeong | Bulletin of the Korean Chemical Society2002, 23(7), 1003-1110 | 2002 | https://doi.org/10.5012/bkcs.2002.23.7.1003 | ||
| 269 | Synthesis and PTP1B Inhibition of 1,2-Naphthoquinone Derivatives as Potent Anti-Diabetic Agents | Jin Hee Ahn,y Sung Yun Cho,y Jae Du Ha,y So Young Chu, Sun Ho Jung, Yoon Sung Jung, Ji Yoen Baek, In Kyung Choi, Eun Young Shin, Seung Kyu Kang, Sung Soo Kim, Hyae Gyeong Cheon, Sung-Don Yang and Joong-Kwon Choi | Bioorganic & Medicinal Chemistry Letters2002, 12, 1941-1946 | 2002 | https://doi.org/10.1016/S0960-894X(02)00331-1 |
2022
| # | Title | Author(s) | Journal | Year | link |
|---|---|---|---|---|---|
| Identification of a Target Site for Covalent Inhibition of Protein Phosphohistidine Phosphatase 1 | Hyeong Jun Kim,† Hoyoung Jung,† Soyeon Kim, Jeong Kon Seo,* and Jung-Min Kee* | ACS Medicinal Chemistry Letters 2022, 13, 12, 1911–1915 | 2022 | https://doi.org/10.1021/acsmedchemlett.2c00450 | |
| PredMS: a random forest model for predicting metabolic stability of drug candidates in human liver microsomes | Jae Yong Ryu*, Jeong Hyun Lee, Byung Ho Lee, Jin Sook Song, Sunjoo Ahn and Kwang-Seok Oh* | Bioinformatics 2022, 38(2), 364–368 | 2022 | https://doi.org/10.1093/bioinformatics/btab547 | |
| A simple protein histidine kinase activity assay for high-throughput inhibitor screening | Donghee Lee, Yunmi Lee, SonHye Shin, SuMin Choi, ShinHyeon Lee, Seonghun Jeong, Soojin Jang*, Jung-Min Kee* | Bioorganic Chemistry 2022, 130, 106232 | 2022 | https://doi.org/10.1016/j.bioorg.2022.106232 | |
| Pharmacological inhibition of AIMP2 aggregation attenuates α-synuclein aggregation and toxicity in Parkinson’s disease | Jeong-YongShin, BinaLee, Sangwoo Ham, Ji Hun Kim, Hyojung Kim, Heejeong Kim, Min Gi Jo, Hye Jung Kim, Sang Won Park, Hee-Seok Kweon, Yong Jun Kim, Seung Pil Yun, Yunjong Lee* | Biomedicine & Pharmacotherapy 2022, 156, 113908 | 2022 | https://doi.org/10.1016/j.biopha.2022.113908 | |
| 1,3-Dibenzyl-5-Fluorouracil Prevents Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Differentiation | Hyoeun Jeon, Jungeun Yu, Jung Me Hwang, Hye-Won Park, Jiyeon Yu, Zee-Won Lee, Taesoo Kim, and Jaerang Rho* | Immune Network 2022, 26;22(5):e43 | 2022 | https://doi.org/10.4110/in.2022.22.e43 | |
| DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis | Jee-Heun Kim, So-Yeon Park, So-El Jeon, Jang-Hyun Choi, Choong-Jae Lee, Tae-Young Jang, Hyeon-Ji Yun, Yuno Lee, Pilho Kim, Sang Hee Cho, Ji Shin Lee, Jeong-Seok Nam* | Theranostics 2022, 12(12):5258-5271 | 2022 | https://www.thno.org/v12p5258.htm | |
| AI-based prediction of new binding site and virtual screening for the discovery of novel P2X3 receptor antagonists | Koon Mook Kang, Ingoo Lee, Hojung Nam*, Yong-Chul Kim* | European Journal of Medicinal Chemistry 2022, 240, 114556 | 2022 | https://doi.org/10.1016/j.ejmech.2022.114556 | |
| Anti-biofilm effects of sinomenine against Staphylococcus aureus | Su-Jin Yum, Hee Gon Jeong* & Seung Min Kim* | Food Science and Biotechnology | 2022 | https://doi.org/10.1007/s10068-022-01174-0 | |
| Combining structure-based pharmacophore modeling and machine learning for the identification of novel BTK inhibitors | Tanuj Sharma, Venu Venkatarame Gowda Saralamma, Duk Chul Lee, Mohammad Azhar Imran, Jaehyuk Choi, Mohammad Hassan Baig*, Jae-June Dong* | International Journal of Biological Macromolecules 2022, 222, 239-250 | 2022 | https://doi.org/10.1016/j.ijbiomac.2022.09.151 | |
| Discovery of GSK3β Inhibitors through In Silico Prediction-and-Experiment Cycling Strategy, and Biological Evaluation | Yuno Lee, Sae-Bom Yoon, Hyowon Hong, Hyun Young Kim, Daeyoung Jung, Byoung-San Moon, Woo-Kyu Park, Sunkyung Lee, Hyukjin Kwon, Jihyeong Park, Heeyeong Cho* | Molecules 2022, 27(12), 3825 | 2022 | https://doi.org/10.3390/molecules27123825 | |
| CDI Exerts Anti-Tumor Effects by Blocking the FoxM1-DNA Interaction | Woo Dae Jang, Mi Young Lee, Jihye Mun, Gyutae Lim and Kwang-Seok Oh* | Biomedicines 2022, 10, 1671 | 2022 | https:// doi.org/10.3390/ biomedicines10071671 | |
| AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis | Dae Gyu Kim, Yongseok Choi, Yuno Lee, Semi Lim, Jiwon Kong, JaeHa Song, Younah Roh, Dipesh S. Harmalkar, Kwanshik Lee, Ja-il Goo, Hye Young Cho, Ameeq Ul Mushtaq, Jihye Lee, Song Hwa Park, Doyeun Kim, Byung Soh Min, Kang Young Lee, Young Ho Jeon, Sunkyung Lee, Kyeong Lee* & Sunghoon Kim* | Nature Communications, 2022, 13:2572 | 2022 | https://doi.org/10.1038/s41467-022-30149-2 | |
| Novel Thioxothiazolo[3,4-a]quinazolin-5(4H)-one Derivatives as BKCa Channel Activators for Urinary Incontinence | Eun Jung Bae, Heeji Jo, Seong Soon Kim, Dae-Seop Shin, Jung Yoon Yang, Myung Ae Bae, Pyeonghwa Jeong, Chul-Seung Park*, and Jin Hee Ahn* | ACS Medicinal Chemistry Letters, online | 2022 | https://doi.org/10.1021/acsmedchemlett.2c00070 | |
| BayeshERG: a robust, reliable and interpretable deep learning model for predicting hERG channel blockers | Hyunho Kim, Minsu Park, Ingoo Lee, Hojung Nam* | Briefings in Bioinformatics, 2022, bbac211 | 2022 | https://doi.org/10.1093/bib/bbac211 | |
| Discovery and characterization of a potent activator of the BKCa channel that relives overactive bladder syndrome in rats | Heeji Jo, Eun Jung Bae, Narasaem Lee, Jae Won Kwon, Suhan Cho, Sung Joon Kim, Jin Hee Ahn, Chul-Seung Park* | European Journal of Pharmacology | 2022 | https://doi.org/10.1016/j.ejphar.2022.175055 | |
| Eltrombopag as an Allosteric Inhibitor of the METTL3-14 Complex Affecting the m6A Methylation of RNA in Acute Myeloid Leukemia Cells | Je-Heon Lee, Namjeong Choi, Subin Kim, Mi Sun Jin*, Haihong Shen* and Yong-Chul Kim* | Pharmaceuticals 2022, 15(4), 440 | 2022 | https://doi.org/10.3390/ph15040440 | |
| 1 | Discovery of harmalanium halides as anti-ovarian cancer agents | Yunha Choi, Sang Hee Ji, Vineet Patil, Eun Hye Kim, Hoyeong Park, Seong Hwan Kim*, Pilho Kim* | Bulletin of the Korean Chemical Society 2022, 43(4), 559-563 | 2022 | https://doi.org/10.1002/bkcs.12498 |
| 2 | Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin | Na Hui Kim, Minji Kwon, Jiwoo Jung, Hyo Byeong Chae, Jiwoo Lee, Yeo-Jun Yoon, In Seok Moon, Ho K. Lee, Wan Namkung, Konstantina M. Stankovic, Se A. Lee, Jong Dae Lee* & Sin-Aye Park* | Acta Pharmacologica Sinica | 2022 | https://doi.org/10.1038/s41401-022-00908-4 |
| 3 | Discovery and synthesis of 1,2,4-oxadiazole derivatives as novel inhibitors of Zika, dengue, Japanese encephalitis, and classical swine fever virus infections | Sangwoo Nam, Hyo Gyeong Na, Eun Hye Oh, Eunhye Jung, Yeon Hee Lee, Eun Ju Jeong, Yu-Da Ou, Bin Zhou, Sunjoo Ahn, Jin Soo Shin, Soo Bong Han* & Yun Young Go* | Archives of Pharmacal Research | 2022 | https://doi.org/10.1007/s12272-022-01380-8 |
| 4 | Identification and New Indication of Melanin-Concentrating Hormone Receptor 1 (MCHR1) Antagonist Derived from Machine Learning and Transcriptome-Based Drug Repositioning Approaches | Gyutae Lim , Ka Young You, Jeong Hyun Lee, Moon Kook Jeon, Byung Ho Lee, Jae Yong Ryu* and Kwang-Seok Oh* | International Journal of Molecular Sciences 2022, 23(7), 3807 | 2022 | https://doi.org/10.3390/ijms23073807 |
| 5 | Discovery of substituted indole derivatives as allosteric inhibitors of m6A-RNA methyltransferase, METTL3-14 complex | Je-Heon Lee,Subin Kim,Mi Sun Jin,Yong-Chul Kim* | DRUG DEVELOPMENT RESEARCH online | 2022 | https://doi.org/10.1002/ddr.21910 |
| 6 | Synthesis and Structure?밃ctivity Relationship Studies of Benzimidazole-4,7-dione-Based P2X3 Receptor Antagonists as Novel Anti-Nociceptive Agents | Jinsu Bae, Yeo-Ok Kim, Xuehao Han, Myung-Ha Yoon, Woong-Mo Kim,* and Yong-Chul Kim* | Molecules 2022, 27, 1337 | 2022 | https://doi.org/10.3390/molecules27041337 |
| 7 | Development of in vitro three-dimensional drug screening system for obesity-related metabolic syndrome | Kyoung Jin Choi, Joon Ho Lee, Sung Bum Park, Yoon-Ju Na, Won Hoon Jung ,Hyuk Lee*, Ki Young Kim* | Journal of Pharmacological Sciences 2022, 148(4),377-386 | 2022 | https://doi.org/10.1016/j.jphs.2022.02.002 |
| 8 | Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer’s disease mice | Min Hee Park, Kang Ho Park, Byung Jo Choi, Wan Hui Han, Hee Ji Yoon, Hye Yoon Jung, Jihoon Leed, Im-Sook Song, Dong Yu Lim, Min-Koo Choi* , Yang-Ha Lee, Cheol-Min Park, Ming Wang, Jihoon Jo, Hee-Jin Kim*, Seung Hyun Kim*, Edward H. Schuchman, Hee Kyung Jin and Jae-sung Bae | PNAS 2022, 119(3), e2115082119 | 2022 | https://doi.org/10.1073/pnas.2115082119 |
| 9 | Discovery of Mycobacterium tuberculosis Rv3364c-Derived Small Molecules as Potential Therapeutic Agents to Target SNX9 for Sepsis | Daeun Lee, Eunbi Lee, Sein Jang, Kyungmin Kim, Euni Cho, Seok-Jun Mun, Wooic Son, Hye-In Jeon, Hyo Keun Kim, Young Jin Jeong, Yuno Lee, Ji Eun Oh, Hye Hyun Yoo, Youngbok Lee, Sun-Joon Min,* and Chul-Su Yang* | Journal of Medicinal Chemistry, 2022, online | 2022 | https://doi.org/10.1021/acs.jmedchem.1c01551 |
2021
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | Discovery and Characterization of a Novel MASTL Inhibitor MKI-2 Targeting MASTL-PP2A in Breast Cancer Cells and Oocytes | Minsung Kang, Chijung Kim, Jiyeon Leem, Ye-hyun Kim, Young-ju Kwon, Yi Na Yoon, Chong Hak Chae, Jiyeon Ahn, Kwan-Young Jung* , Jeong Su Oh* and Jae-Sung Kim* | Pharmaceuticals 2021, 14(7), 647 | 2021 | https://doi.org/10.3390/ph14070647 |
| 2 | Chemical Inhibitors of the Conserved Bacterial Transcriptional Regulator DksA1 Suppressed Quorum Sensing-Mediated Virulence of Pseudomonas aeruginosa | Kyung Bae Min, Wontae Hwang, Kang-Mu Lee, June Beom Kim, Sang Sun Yoon* | Journal of Biological Chemistry 2021, 296, 100576 | 2021 | https://doi.org/10.1016/j.jbc.2021.100576 |
| 3 | Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2–Depleted Splice Variant of Aminoacyl–Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70S | Dae Gyu Kim, Srigouri Huddar, Semi Lim, Jiwon Kong, Yuno Lee, Chul Min Park, Seungbeom Lee, Young-Ger Suh, Minkyoung Kim, Kyeong Lee, Sunkyung Lee and Sunghoon Kim* | The Journal of Pharmacology and Experimental Therapeutics 2021, 379(3), 358-371 | 2021 | https://doi.org/10.1124/jpet.121.000766 |
| 4 | New quinoxaline compounds as DPP-4 inhibitors and hypoglycemics: design, synthesis, computational and bio-distribution studies | Yasmin M. Syam, Manal M. Anwar, Somaia S. Abd El-Karim, Samia A. Elseginy, Basma M. Essa and Tamer M. Sakr | RSC Advances 2021,11, 36989-37010 | 2021 | https://pubs.rsc.org/en/content/articlelanding/2021/RA/D1RA06799K |
| 5 | Di (Isoquinolin-1-Yl) Sulfane (DIQS) Inhibits Melaninogenesis by Modulating PKA/CREB and MAPK Signaling Pathways | Jung Yoon Yang, Dae-Seop Shin, Kyu-Seok Hwang, Seong Soon Kim, Byung Hoi Lee, Se Hwan Ahn, Jin Hee Ahn and Myung Ae Bae* | Cosmetics 2021, 8(4), 104 | 2021 | https://doi.org/10.3390/cosmetics8040104 |
| 6 | Aberrant activation of the CD45-Wnt signaling axis promotes stemness and therapy resistance in colorectal cancer cells | So-Yeon Park, Ji-Young Kim, Gyu-Beom Jang, Jang-Hyun Choi, Jee-Heun Kim, Choong-Jae Lee, Sunjae Lee, Jeong-Heum Baek, Kwan-Kyu Park, Jin-Man Kim, Hee Jin Chang, Nam-Chul Cho, and Jeong-Seok Nam* | Theranostics 2021, 11(18), 8755-8770 | 2021 | https://www.thno.org/v11p8755.htm |
| 7 | Development of a FOXM1-DBD Binding Assay for High-Throughput Screening Using TR-FRET Assay | Mi Young Lee, Chae Eun Haam, Jihye Mun, Gyutae Lim, Byung Ho Lee, and Kwang-Seok Oh* | Biological and Pharmaceutical Bulletin 2021, 44(10), 1484–1491 | 2021 | https://www.jstage.jst.go.jp/article/bpb/44/10/44_b21-00322/_pdf |
| 8 | Screening of small molecules attenuating biofilm formation of Acinetobacter baumannii by inhibition of ompA promoter activity | Seok Hyeon Na, Hyejin Jeon, Man Hwan Oh, Yoo Jeong Kim & Je Chul Lee* | Journal of Microbiology 2021, 59, 871–878 | 2021 | https://doi.org/10.1007/s12275-021-1394-z |
| 9 | Identification of new IL-7Rα small-molecule agonists: a multi-computational approach | J-Y Lee, K Lee, B Koh | SAR and QSAR in Environmental Research 2021, 32, 719-729 | 2021 | https://doi.org/10.1080/1062936X.2021.1969684 |
| 10 | Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1 | Jain Ha, Sewoong Lee, Jiyoung Park, Jihye Seo, Eunjeong Kang, Haelim Yoon, Ba Reum Kim, Hyeon Kyu Lee, Seong Eon Ryu* & Sayeon Cho* | Scientific Reports 2021, 11:16765 | 2021 | https://doi.org/10.1038/s41598-021-95933-4 |
| 11 | A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses | Dae-Gyun Ahn, Gun Young Yoon, Sunhee Lee, Keun Bon Ku, Chonsaeng Kim, Kyun-Do Kim, Young-Chan Kwon, Geon-Woo Kim, Bum-Tae Kim and Seong-Jun Kim* | Viruses 2021, 13(8), 1639 | 2021 | https://doi.org/10.3390/v13081639 |
| 12 | Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes | Miri Choi, Ae-kyeong Kim, Youngwook Ham, Joo-Youn Lee, Daeyong Kim, Ansook Yang, Min Ju Jo, Eunyoung Yoon, Jung-Nyoung Heo, Sang-Bae Han, Min-Hyo Ki, Kyu-Sun Lee, Sungchan Cho* | Phytomedicine 2021, 92, 153695 | 2021 | https://doi.org/10.1016/j.phymed.2021.153695 |
| 13 | PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease | Areum Jo, Yunjong Lee, Tae-In Kam, Sung-Ung Kang, Stewart Neifert, Senthilkumar S. Karuppagounder, Rin Khang, Hojin Kang, Hyejin Park, Shih-Ching Chou, Sungtaek Oh, Haisong Jiang, Deborah A. Swing, Sangwoo Ham, Sheila Pirooznia, George K. E. Umanah, Xiaobo Mao, Manoj Kumar, Han Seok Ko, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Shaida A. Andrabi, Chi-Hu Park, Ji-Yeong Lee, Hanna Kim, Hyein Kim, Hyojung Kim, Jin Whan Cho, Sun Ha Paek, Chan Hyun Na, Lino Tessarollo, Valina L. Dawson, Ted M. Dawson*, Joo-Ho Shin* | Science Translational Medicine 2021, 13(604), eaax8891 | 2021 | https://stm.sciencemag.org/content/scitransmed/13/604/eaax8891.full.pdf |
| 14 | Antiviral Activity of Isoquinolone Derivatives against Influenza Viruses and Their Cytotoxicity | Yejin Jang, Jinhe Han, Xiaoli Li, Hyunjin Shin, Won-Jea Cho* and Meehyein Kim* | Pharmaceuticals 2021, 14(7), 650 | 2021 | https://doi.org/10.3390/ph14070650 |
| 15 | Efficient kinetic resolution in the asymmetric transfer hydrogenation of 3-aryl-indanones: applications to a short synthesis of (+)-indatraline and a formal synthesis of (R)-tolterodine† | Songsoon Park, Hyeon-Kyu Lee* | RSC Advances 2021,11, 23161-23183 | 2021 | https://doi.org/10.1039/D1RA04538E |
| 16 | SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation | Hye Jin Shin, Keun Bon Ku, Gun Young Yun, Hyun-Woo Moon, Chonsaeng Kim, Bum-Tae Kim, Jong-Won Oh, Aleem Siddiqui, and Seong-Jun Kim,* | Research Square 2021, online | 2021 | https://doi.org/10.21203/rs.3.rs-593889/v1 |
| 17 | Structure-Based Virtual Screening: Identification of a Novel NS2B-NS3 Protease Inhibitor with Potent Antiviral Activity against Zika and Dengue Viruses | Hye Jin Shin, Mi-Hwa Kim, Joo-Youn Lee, Insu Hwang, Gun Young Yoon, Hae Soo Kim, Young-Chan Kwon, Dae-Gyun Ahn, Kyun-Do Kim, Bum-Tae Kim, Seong-Jun Kim*, Chonsaeng Kim* | Microorganisms 2021, 9(3), 545 | 2021 | https://doi.org/10.3390/microorganisms9030545 |
| 18 | Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced lipotoxicity and gluconeogenesis in a murine model | Hye-Eun Choi, YuSik Kim, Han-Joo Lee, Hyae Gyeong Cheon* | European Journal of Pharmacology 2021, 899, 174011 | 2021 | https://doi.org/10.1016/j.ejphar.2021.174011 |
| 19 | A new KSRP-binding compound suppresses distant metastasis of colorectal cancer by targeting the oncogenic KITENIN complex | Jeong A Bae, Woo Kyun Bae, Sung Jin Kim, Yoo-Seung Ko, Keon Young Kim, So-Yeon Park, Young Hyun Yu, Eun Ae Kim, Ik Joo Chung, Hangun Kim, Hyung-Ho Ha & Kyung Keun Kim | Molecular Cancer 2021, 20, 78 | 2021 | https://doi.org/10.1186/s12943-021-01368-w |
| 20 | Anti-Cancer Effects of Glaucarubinone in the Hepatocellular Carcinoma Cell Line Huh7 via Regulation of the Epithelial-To-Mesenchymal Transition-Associated Transcription Factor Twist1 | Jihye Seo, Jain Ha, Eunjeong Kang, Haelim Yoon, Sewoong Lee, Shi Yong Ryu, Kwonseop Kim and Sayeon Cho* | International Journal of Molecular Sciences 2021, 22(4), 1700 | 2021 | https://doi.org/10.3390/ijms22041700 |
| 21 | Discovery of μ,δ-Opioid Receptor Dual-Biased Agonists That Overcome the Limitation of Prior Biased Agonists | Jin Hee Lee, Suh-Youn Shon, Woojin Jeon, Sung-Jun Hong, Junsu Ban, and Do Sup Lee* | ACS Pharmacology & Translational Science 2021, online | 2021 | https://doi.org/10.1021/acsptsci.1c00044 |
| 22 | Sildenafil prevents HDACi-induced Epstein-Barr virus reactivation through the PKG pathway in NK/T cell lymphoma; potential implications for HDACi-mediated fatal complications | Joo Hyun Kim, Won Seog Kim*, Chaehwa Park* | Antiviral Research 2021, 189, 105063 | 2021 | https://doi.org/10.1016/j.antiviral.2021.105063 |
| 23 | Identification of non-covalent 3C-like protease inhibitors against severe acute respiratory syndrome coronavirus-2 via virtual screening of a Korean compound library | Joo-Youn Lee, Chih-Jung Kuo, Jin Soo Shin, Eunhye Jung, Po-Huang Liang*, and Young-Sik Jung* | Bioorganic & Medicinal Chemistry Letters 2021, 42, 128067 | 2021 | https://doi.org/10.1016/j.bmcl.2021.128067 |
| 24 | Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments | Jun Young Lee, Young Sup Shin, Sangeun Jeon, Se In Lee, Soojin Noh, Jung-Eun Cho, Min Seong Jang, Seungtaek Kim, Jong Hwan Song, Hyoung Rae Kim, Chul Min Park* | Bioorganic & Medicinal Chemistry Letters 2021, 39, 127885 | 2021 | https://doi.org/10.1016/j.bmcl.2021.127885 |
| 25 | Antimicrobial activity of IDD-B40 against drug-resistant Mycobacterium tuberculosis | Md Imtiazul Islam, Hoonhee Seo, Sukyung Kim, Venkata S. Sadu, Kee-In Lee & Ho-Yeon Song | Scientific Reports 2021,11,740 | 2021 | https://www.nature.com/articles/s41598-020-80227-y |
| 26 | Radicicol Inhibits Chikungunya Virus Replication by Targeting Nonstructural Protein-2 | Sangwoo Nam, Yun Ji Ga, Joo-Youn Lee, Woo-Yeon Hwang, Eunhye Jung, Jinsoo Shin, Weiyi Chen, Gildon Choi, Bin Zhou, Jung-Yong Yeh, Yun Young Go* | Antimicrobial Agents and Chemotherapy 2021, 65(7), e00135-21 | 2021 | https://doi.org/10.1128/AAC.00135-21 |
| 27 | Application of the antitussive agents oxelaidin and butamirate as anti-glioma agents | Sook-Ja Lee, Seon-Yong Yeom, Jee-Young Lee & Chaehwa Park* | Scientific Reports 2021, 11:10145 | 2021 | https://doi.org/10.1038/s41598-021-89238-9 |
| 28 | Novel brd4 inhibitors with a unique scaffold exhibit antitumor effects | Young Hun Kim, Minsung Kim, Ji Eun Kim, Miyoun Yoo, Heung Kyoung Lee, Chong Ock Lee, Minjin Yoo, Kwan-Young Jung, Yeongrin Kim, Sang Un Choi, Chi Hoon Park* | Oncology Letters 2021, 21(6), 473 | 2021 | https://doi.org/10.3892/ol.2021.12734 |
| 29 | TIMP-1-expressing breast tumor spheroids for the evaluation of drug penetration and efficacy | In Yeong Bae, Wooshik Choi, Seung Ja Oh, Chansoo Kim, Sang-Heon Kim* | Bioengineering & Translational Medicine 2021, e10286 | 2021 | https://doi.org/10.1002/btm2.10286 |
| 30 | A microwave-assisted synthetic approach to analyzing disubstituted pyrrolo[2,3-d]pyrimidine diversity via ligand-free Cu-catalyzed N-arylation | Chang Sung Hong, Seung Yeong Park, Jeong Seob Byeon, Eul Kgun Yum* | Bulletin of the Korean Chemical Society 2021, 42(12), 1641-1649 | 2021 | https://doi.org/10.1002/bkcs.12422 |
| 31 | Therapeutic Effects of Inhibitor of ompA Expression against Carbapenem-Resistant Acinetobacter baumannii Strains | Seok-Hyeon Na, Hyejin Jeon, Man-Hwan Oh, Yoo-Jeong Kim, Mingi Chu, Ill-Young Lee and Je-Chul Lee* | International Journal of Molecular Sciences 2021, 22(22), 12257 | 2021 | https://doi.org/10.3390/ijms222212257 |
2020
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | In Silico Exploration of Conformational Dynamics and Novel Inhibitors for Targeting MEF2-Associated Transcriptional Activity | Ayisha Zia Orcid, Muhammad Imran and Sajid Rashid* | Journal of Chemical Information and Modeling 2020, 60, 1892−1909 | 2020 | https://doi.org/10.1021/acs.jcim.0c00008 |
| 2 | Development and structure-activity relationship study of SHP2 inhibitor containing3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene | Bohee Kim, Seungjin Jo, Sung Bum Park, Chong Hak Chae, Kwangho Lee, Byumseok Koh*, Inji Shin* | Bioorganic & Medicinal Chemistry Letters 2020, 30(1), 126756 | 2020 | https://doi.org/10.1016/j.bmcl.2019.126756 |
| 3 | Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agent | Bui Thi Bich Hanh, June-Woo Park, Tae Ho Kim, Jae-Sung Kim, Chul-Su Yang, Kiseok Jang, Jinsheng Cui, Dong-Chan Oh and Jichan Jang* | Molecules 2020, 25(7), 1597 | 2020 | https://doi.org/10.3390/molecules25071597 |
| 4 | Discovery of a Novel Chemical Scaffold Against Mutant Isocitrate Dehydrogenase 1 (IDH1) | Chung Hyo Kang, Sang Un Choi, You Hwa Son, Heung Kyoung Lee, Hye Gwang Jeong , Chang-Soo Yun, Sunjoo Ahn, Chi Hoon Park | Anticancer Research 2020, 40(9): 4929-4935 | 2020 | http://ar.iiarjournals.org/content/40/9/4929 |
| 5 | Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2 | Dae Gyu Kim, Chul Min Park, Srigouri Huddar, Semi Lim, Sunghoon Kim*, Sunkyung Lee* | Molecules 2020, in press | 2020 | https://chembank.org/%ed%99%9c%ec%9a%a9%eb%85%bc%eb%ac%b8/ |
| 6 | Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity | Dong-Gyun Kim, Sujin Cho, Kyu-Yeon Lee, Seung-Ho Cheon, Hye-Jin Yoon, Joo-Youn Lee, Dongyoon Kim, Kwang-Soo Shin, Choong-Hyun Koh, Ji Sung Koo, Yuri Choi, Hyung Ho Lee, Yu-Kyoung Oh, Yoo-Seong Jeong, Suk-Jae Chung, Moonkyu Baek, Kwan-Young Jung, Hyo Jin Lim, Hyoun Sook Kim, Sung Jean Park, Jeong-Yeon Lee, Sang Jae Lee* & Bong-Jin Lee* | Cellular and Molecular Life Sciences 2021, 78(1), 207-225 | 2020 | https://doi.org/10.1007/s00018-020-03490-2 |
| 7 | Peripheral Inhibition of Small C‐Terminal Domain Phosphatase 1 With Napthoquinone Analogs | Harikrishna Reddy Rallabandi, Dongsun Lee, Jinmo Sung, YoungJun Kim | Bulletin of the Korean Chemical Society 2020, 41(6), 657-664 | 2020 | https://doi.org/10.1002/bkcs.12051 |
| 8 | Autophagic inhibition via lysosomal integrity dysfunction leads to antitumor activity in glioma treatment | Hui-Yun Hwang, Yoon Sun Cho, Jin Young Kim, Ki Na Yun, Jong Shin Yoo, Eunhyeong Lee, Injune Kim and Ho Jeong Kwon* | Cancers 2020, 12(3), 543 | 2020 | https://doi.org/10.3390/cancers12030543 |
| 9 | TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation | Hyun-Kyoung Kim, Kashi Raj Bhattarai, Raghu Patil Junjappa, Jin Hee Ahn, Suvarna H. Pagire, Hyun Ju Yoo, Jaeseok Han, Duckgue Lee, Kyung-Woon Kim, Hyung-Ryong Kim *, Han-Jung Chae* | Nature Communications 2020, 11, 4012 | 2020 | https://www.nature.com/articles/s41467-020-17802-4 |
| 10 | Identification of a New Chemotype of Anti-Obesity Compounds by Ensemble Screening | Hyunkyung Cho, Joo-Youn Lee, Sang Yoon Choi, Chaemin Lim, Min-Kyoung Park, Hyejin An, Jeong Ok Lee, Minsoo Noh, Seunghee Lee* and Sanghee Kim* | ACS Omega 2020, 5, 8, 4338-4346 | 2020 | https://doi.org/10.1021/acsomega.9b04454 |
| 11 | Role of RS-1 derivatives in homology-directed repair at the human genome ATG5 locus | In-Sook Jeon, Jae-Cheon Shin, Seung Ryul Kim, Kwan Sik Park, Hyun Jung Yoo, Kwang Youl Lee, Hak-Kyo Lee, Joong-Kook Choi | Archives of Pharmacal Research 2020, in press | 2020 | https://link.springer.com/article/10.1007/s12272-020-01226-1 |
| 12 | DeepHIT: a deep learning framework for prediction of hERG-induced cardiotoxicity | Jae Yong Ryu*, Mi Young Lee, Jeong Hyun Lee, Byung Ho Lee and Kwang-Seok Oh* | Bioinformatics 2020, 36(10), 3049–3055 | 2020 | https://doi.org/10.1093/bioinformatics/btaa075 |
| 13 | L-type Calcium Channel Blocker Enhances Cellular Delivery and Gene Silencing Potency of Cell-Penetrating Asymmetric siRNAs | Jeong Yong Choe, Da Seul Son, Yanghee Kim, Jun-kyoung Lee, Hanho Shin, Won Jun Kim, Young Gyu Kang, Pooja Dua, Sun Woo Hong, June Hyun Park and Dong-ki Lee* | Molecular Pharmaceutics 2020, 17, 3, 777-786 | 2020 | https://doi.org/10.1021/acs.molpharmaceut.9b00942 |
| 14 | Identification of Diphenoxylate as an Antiviral Agent Against Severe Acute Respiratory Syndrome Coronavirus 2 | Jin Soo Shin Eunhye Jung Yejin Jang Soo Bong Han Meehyein Kim* | ChemRxivs 2020, in press | 2020 | https://doi.org/10.26434/chemrxiv.12496547.v1 |
| 15 | In silico screening of GABA aminotransferase inhibitors from the constituents of Valeriana officinalis by molecular docking and molecular dynamics simulation study | Jin-Young Park, Yuno Lee, Hee Jae Lee, Yong-Soo Kwon, Wanjoo Chun* | Journal of Molecular Modeling 2020, 26, 228 | 2020 | https://link.springer.com/article/10.1007/s00894-020-04495-1#Sec9 |
| 16 | Inhibitory effects on Streptococcus mutans of antibacterial agents mixed withexperimental fluoride varnish | Ju-Lee SON, Ah-Jin KIM, Seunghan OH, Ji-Myung BAE | Dental Materials Journal 2020, in press | 2020 | https://doi.org/10.4012/dmj.2020-016 |
| 17 | Identification of 4-Anilino-6-aminoquinazoline Derivatives as Potential MERS-CoV Inhibitors | Jun Young Lee, Young Sup Shin, Jihye Lee, Sunoh Kwon, Young-hee Jin, Min Seong Jang, Seungtaek Kim, Jong Hwan Song, Hyoung Rae Kim, Chul Min Park* | Bioorganic & Medicinal Chemistry Letters 2020, 30(20), 127472 | 2020 | https://www.sciencedirect.com/science/article/pii/S0960894X20305837 |
| 18 | Efficacy and pharmacokinetics evaluation of 4-(2-chloro-4-fluorobenzyl)-3-(2-thienyl)-1,2,4-oxadiazol-5(4H)-one (GM-90432) as an anti-seizure agent | Kyu-Seok Hwang, Hyemin Kan, Seong Soon Kim, Jin Sil Chae, Jung Yoon Yang, Dae-Seop Shin, Se Hwan Ahn, Jin Hee Ahn, Jin-Hwa Cho, Il-Sung Jang, Junnyeong Shin, Jaeyoung Joo, Cheol-Hee Kim, Myung Ae Bae* | Neurochemistry International 2020, 141,104870 | 2020 | https://doi.org/10.1016/j.neuint.2020.104870 |
| 19 | Chemical Inhibitors of DksA1, a Conserved Bacterial Transcriptional Regulator, Suppressed Quorum Sensing-Mediated Virulence in Pseudomonas aeruginosa | Kyung Bae Min, Wontae Hwang, Kang-Mu Lee, Sang Sun Yoon | bioRxiv | 2020 | https://doi.org/10.1101/2020.12.10.420422 |
| 20 | A novel tyrosine kinase inhibitor can augment radioactive iodine uptake through endogenous sodium/iodide symporter (NIS) expression in anaplastic thyroid cancer | Ms. Ji Min Oh, Mr. Se Hwan Baek, Dr. Prakash Gangadaran, Dr. Chae Moon Hong, Dr. Ramya Lakshmi Rajendran, Dr. Ho Won Lee, Mr. Liya Zhu, Mr. Arunnehru gopal, Dr. Senthilkumar Kalimuthu, Prof. Shin Young Jeong, Dr. Sang-Woo Lee, Dr. Jaetae Lee, and Dr. Byeong-Cheol Ahn* | Thyroid 2020, 30(4), 501-518 | 2020 | https://doi.org/10.1089/thy.2018.0626 |
| 21 | Selection and functional identification of a synthetic partial ABA agonist, S7 | Myung Ki Min, Rigyeong Kim, Seok-Jun Moon, Yongsang Lee, Seungsu Han, Sangho Lee & Beom-Gi Kim* | Scientific Reports 2020, 10(4) | 2020 | https://doi.org/10.1038/s41598-019-56343-9 |
| 22 | A computational drug repurposing approach in identifying the cephalosporin antibiotic and anti-hepatitis C drug derivatives for COVID-19 treatment | Raj Kumar, Vikas Kumar, Keun Woo Lee | Computers in Biology and Medicine 2020, 130, 104186 | 2020 | https://doi.org/10.1016/j.compbiomed.2020.104186 |
| 23 | Application of multi-omics technology for the elucidation of anti-pneumococcal activity of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one (APDQ) derivative against Streptococcus pneumoniae | Sang‑Yeop Lee, Hayoung Lee, Sung Ho Yun, Sangmi Jun, Yujeong Lee, Wooyoung Kim, Edmond Changkyun Park, Joonyoung Baek, Yoonna Kwak, Soojin Noh, Giwan Seo, Soojin Jang, Chul Min Park* & Seung Il Kim* | Scientific Reports 2020, 10:20685 | 2020 | https://doi.org/10.1038/s41598-020-77694-8 |
| 24 | Identification of new arylsulfide derivatives as anti-melanogenic agents in a zebrafish model | Se Hwan Ahn, Kyu-Seok Hwang, Dae-Seop Shin, Seong Soon Kim, Jung Yoon Yang, Byung Hoi Lee, Eun Jung Bae, Byeong Wook Choi, Myung Ae Bae, Jin Hee Ahn | Bioorganic & Medicinal Chemistry Letters 2020, 30(13), 127201 | 2020 | https://doi.org/10.1016/j.bmcl.2020.127201 |
| 25 | Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR | Seung Min Kim, Jongmin Park, Myun Soo Kim, Heebum Song, Ala Jo, Hankum Park, Tae Sung Kim, Sang Ho Choi,* and Seung Bum Park | ACS Infectious Diseases | 2020 | https://doi.org/10.1021/acsinfecdis.0c00587 |
| 26 | Discovery of 4-hydroxy-2-oxo-1,2-dihydroquinolines as potential inhibitors of Streptococcus pneumoniae, including drug-resistant strains | Srigouri Huddar, Chul Min Park, Hyung Jun Kim, Soojin Jang, Sunkyung Lee | Bioorganic & Medicinal Chemistry Letters 2020, 30(9), 127071 | 2020 | https://doi.org/10.1016/j.bmcl.2020.127071 |
| 27 | Diversification of Heteroaryl‐Aryl Ether via Ligand‐Free, Copper‐Catalyzed O‐Arylation Under Microwave Heating | Sung Min Choi, Jeong Seob Byeon, Eul Kgun Yum* | Bulletin of the Korean Chemical Society 2020, 41(8), 837-842 | 2020 | https://onlinelibrary.wiley.com/doi/full/10.1002/bkcs.12075 |
| 28 | Structural and Functional Study of the Klebsiella pneumoniae VapBC Toxin–Antitoxin System, Including the Development of an Inhibitor That Activates VapC | Sung-Min Kang, Chenglong Jin, Do-Hee Kim, Yuno Lee, Bong-Jin Lee* | Journal of Medicinal Chemistry | 2020 | https://doi.org/10.1021/acs.jmedchem.0c01118 |
| 29 | Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles | Yi-Seul Yoon, Yejin Jang, Thomas Hoenen, Heegwon Shin, Younghoon Lee & Meehyein Kim* | BMB Reports 2020, 53(3), 166-171 | 2020 | https://doi.org/10.5483/BMBRep.2020.53.3.175 |
| 30 | Punicalagin Ameliorates Lupus Nephritis via Inhibition of PAR2 | Yohan Seo, Chin Hee Mun, So-Hyeon Park, Dongkyu Jeon, Su Jeong Kim, Taejun Yoon, Eunhee Ko, Sungwoo Jo, Yong-Beom Park, Wan Namkung, and Sang-Won Lee | International Journal of Molecular Sciences 2020, 21(14): 4975 | 2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404282/ |
| 31 | Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2 | Young Sup Shin, Jun Young Lee, Soojin Noh, Yoonna Kwak, Sangeun Jeon, Sunoh Kwon, Young-hee Jin, Min Seong Jang, Seungtaek Kim, Jong Hwan Song, Hyoung Rae Kim, Chul Min Park* | Bioorganic & Medicinal Chemistry Letters 2020, online, 127667 | 2020 | https://doi.org/10.1016/j.bmcl.2020.127667 |
2019
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | Phenylethylamides derived from bacterial secondary metabolites specifically inhibit an insect serotonin receptor | Ariful Hasan, Hyun-Suk Yeom, Jaewook Ryu, Helge B. Bode & Yonggyun Kim | Scientific Reports20358 (2019) | 2019 | https://doi.org/10.1038/s41598-019-56892-z |
| 2 | Discovery of (E)-5,5-Difluoro-1-[2-[5-(3-fluorophenyl)pyridin-2-yl]vinyl]octahydrospiro(indene-2,5′-oxazolidin)-2′-one as a PAR1 Antagonist | Chul Min Park, Sunkyung Lee, Song Jong Hwan, Lee Joo Youn | Bulletin of the Korean Chemical Society2019, 40, 658-667 | 2019 | https://doi.org/10.1002/bkcs.11747 |
| 3 | Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases | Dahye Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Eun Jung Bae, Mahesh Dighe, Minhee Kim, Kyu Myung Lee, Yoon Kyung Jang, Ashok Kumar Jaladi, Kwan-Young Jung, Eun Kyung Yoo, Hee Eon Gim, Seungmi Lee, Won-Il Choi, Young-In Chi, Jin Sook Song, Myung Ae Bae, Yong Hyun Jeon, Ga-Hyun Lee, Kwang-Hyeon Liu, Taeho Lee, Sungmi Park, Jae-Han Jeon, In-Kyu Lee, and Jin Hee Ahn | Journal of Medicinal Chemistry2019, 62(2), 575-588 | 2019 | https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01168 |
| 4 | Identification of a novel turn-on albumin binding small-molecule bioprobe in live zebrafish and its potential application in drug discovery | Hang-Suk Chun,Seo-Jung Han,Dae-Seop Shin,Haushabhau S.Pagire,Suvarna H.Pagire,Gwi Bin Lee,Chong Hak Chae,BoryeongPak,Suk-Won Jin,Young-Tae Chang,Seung Bum Park,Jin Hee Ahn,Myung Ae Bae | Dyes and Pigments2019, 171, 107720 | 2019 | https://doi.org/10.1016/j.dyepig.2019.107720 |
| 5 | Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model | Jeong Kun-HeeKim,Dong-Young Kim,GopalakrishnanChandrasekaran,Minhee Kim,Suvarna H.Pagire,Mahesh Dighe,Eun Young Choi,Su-Min Bak,Eun-Young Kim,Myung-Geun Shin,Seok-Yong Choi,Jin Hee Ahn | Bioorganic & Medicinal Chemistry2019, 27(19), 115014 | 2019 | https://doi.org/10.1016/j.bmc.2019.07.030 |
| 6 | A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy | Jessica L. Wojtaszek, Nimrat Chatterjee, Javaria Najeeb, Azucena Ramos, Minhee Lee, Ke Bian, Jenny Y. Xue, Benjamin A. Fenton, Hyeri Park, Deyu Li, Michael T. Hemann, Jiyong Hong, Graham C. Walker, and Pei Zhou | Cell2019, 178(1), 152-159 | 2019 | https://doi.org/10.1016/j.cell.2019.05.028 |
| 7 | Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors | Ji HyeYoon,Jun Young Lee,Jihye Lee,Young Sup Shin,Sangeun Jeon,Dong Eon Kim,Jung Sun Min,Jong Hwan Song,Seungtaek Kim,Sunoh Kwon,Young-hee Jin,Min Seong Jang,Hyoung Rae Kim,Chul Min Park | Bioorganic & Medicinal Chemistry LettersVolume 29, Issue 23, 1 December 2019, 126727 | 2019 | https://doi.org/10.1016/j.bmcl.2019.126727 |
| 8 | Identification of a novel SIRT7 inhibitor as anticancer drug candidate | Ji-Hye Kim, Da hee Kim, Suk Joon Cho, Kwan-Young Jung, Jong-Hoon Kim, Jun Mi Lee, Hee Jung Jung, Kwang Rok Kim | Biochemical and Biophysical Research Communications2019, 508(2), 451-457 | 2019 | https://doi.org/10.1016/j.bbrc.2018.11.120 |
| 9 | The anti-biofilm and anti-virulence activities of trans-resveratrol and oxyresveratrol against uropathogenic Escherichia coli | Jin-Hyung Lee,Yong-Guy Kim,Chaitany Jayprakash Raorane,Shi Yong Ryu,Jae-Jin Shim &Jintae Lee | The Journal of Bioadhesion and Biofilm Research2019, 35(7) 758-767 | 2019 | https://doi.org/10.1080/08927014.2019.1657418 |
| 10 | DITMD-induced mitotic defects and apoptosis in tumor cells by blocking the polo-box domain-dependent functions of polo-like kinase 1 | Ka-Ul Kim, Ju Hee Lee, Mi Young Lee, Chong Hak Chae, Jeong Hyun Lee, Byung Ho Lee, Kwang-Seok Oh | European Journal of Pharmacology2019, 847, 113-122 | 2019 | https://doi.org/10.1016/j.ejphar.2019.01.032 |
| 11 | In vitro activity of DNF-3 against drug resistant Mycobacterium tuberculosis | Md Imtiazu Islam, Choi Moon Han, Hoonhee Seo, Sukyung Kim, Hafij Al Mahmud, Kung-Woo Nam, Byung-Eui Lee, Venkata S. Sadu, Kee-In Lee, Ho-Yeon Song | International Journal of Antimicrobial Agents2019, 54(1), 69-74 | 2019 | https://doi.org/10.1016/j.ijantimicag.2019.02.013 |
| 12 | Potential biomarkers and antagonists for fluoranthene-induced cellular toxicity of bone marrow derived mesenchymal stem cells | Md Moinul Hoque,Young Eun Lee, Hye Ran Kim,and Myung Geun Shin | Synapse2019 Dec;54(4):253-261 | 2019 | https://doi.org/10.5045/br.2019.54.4.253 |
| 13 | Homoharringtonine Induces Apoptosis in Human Colorectal Carcinoma HCT116 Cells Via Downregulation of Wnt/β-Catenin Signaling Cascade | Mikyung Park, Hojeong Kwon, and Seong Hwan Kim | Bulletin of the Korean Chemical Society2019, 40(2), 196-199 | 2019 | https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.11662 |
| 14 | A nano sensor for sensitive and selective detection of Cu2+ based on fluorescein: Cell imaging and drinking water analysis | Prasad G.Mahajan, Nilam C.Dige, Balasaheb D.Vanjare, Seong-Hui Eo, Song Ja Kim, Ki Hwan Lee | Spectrochimica Acta Part A : Molecular and Biomolecular Spectroscopy2019, 216, 105-116 | 2019 | https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.11662 |
| 15 | Facile synthesis of new quinazolinone benzamides as potent tyrosinase inhibitors: Comparative spectroscopic and molecular docking studies | Prasad G.Mahajan,Nilam C.Dige,Balasaheb D.Vanjare,Hussain Raza,Mubashir Hassan,Sung-Yum Seo,Chong- Hyeak Kim,Ki Hwan Lee | Journal of Molecular StructureVolume 1198, 15 December 2019, 126915 | 2019 | https://doi.org/10.1016/j.molstruc.2019.126915 |
| 16 | Stereoselective Synthesis of Highly Functionalized 5- and 6-Membered Aminocyclitols Starting with a Readily Available 2-Azetidinone | Raghavendra Achary, Hyeong Rae Kim, Hyeon-Kyu Lee | The Journal of Organic Chemistry2019, 84(7), 4263-4272 | 2019 | https://pubs.acs.org/doi/pdf/10.1021/acs.joc.9b00239 |
| 17 | Synthesis and Biological Evaluation of PF-543 Derivative Containing Aliphatic Side Chain | Seon Woong Kim, Taeho Lee, Yoon Sin Oh, Sang Mi Shin, Joo-Youn Lee, Sanghee Kim, Dong Jae Baek, and Eun-Young Park | Chemical and Pharmaceutical Bulletin2019, 67(6), 599-603 | 2019 | https://www.jstage.jst.go.jp/article/cpb/67/6/67_c18-00724/_pdf |
| 18 | Fluoranthene-Induced Cytotoxicity and Direct Effect of Aryl Hydrocarbon Receptor Antagonist on Hematopoietic Stem Cell Differentiation | Seung-Hyun Yang,Min-Gu Kang,Hye-Ran Kim,Young Eun Lee,Bo Ram Na,Jun Hyung Lee,Jong-Hee Shin,and Myung-Geun Shin | Ann Lab Med2019 Nov;39(6):580-583 | 2019 | https://doi.org/10.3343/alm.2019.39.6.580 |
| 19 | Thiostrepton: A Novel Therapeutic Drug Candidate for Mycobacterium abscessus Infection | Tae Ho Kim,Bui Thi Bich Hanh,Guehye Kim,Da-Gyum Lee,June-Woo Park,So Eui Lee,Jae-Sung Kim,Byoung Soo Kim,Sungweon Ryoo,Eun-Kyeong Jo,andJichan Jang | Molecules2019, 24(24), 4511 | 2019 | https://doi.org/10.3390/molecules24244511 |
| 20 | Discovery of Small‐Molecule Modulators of Protein–RNA Interactions by Fluorescence Intensity‐Based Binding Assay | Wan Gi Byun Dr. Donghyun Lim Prof. Dr. Seung Bum Park | ChemBioChem2019,20,1–8 | 2019 | https://doi.org/10.1002/cbic.201900467 |
| 21 | Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species | Zee-Won Lee, Byoung Sik Kim, Kyung Ku Jang, Ye-Ji Bang, Suhyeon Kim, Nam-Chul Ha, Young Hyun Jung, Hyun Jik Lee, Ho Jae Han, Jong-Seo Kim, Jeesoo Kim, Pramod K. Sahu, Lak Shin Jeong, Myung Hee Kim & Sang Ho Choi | Scientific Reports2019, 9, 436-449 | 2019 | https://www.nature.com/articles/s41598-019-39554-y |
2018
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | Anti-inflammatory effects of a novel compound, MPQP, through the inhibition of IRAK1 signaling pathways in LPS-stimulated RAW 264.7 macrophages | Ba Reum Kim, Young-Chang Cho & Sayeon Cho | BMB Reports2018, 51(6), 308-313 | 2018 | https://doi.org/10.5483/BMBRep.2018.51.6.064 |
| 2 | Identification of N-(5-(phenoxymethyl)-1,3,4-thiadiazol-2-yl)acetamide derivatives as novel protein tyrosine phosphatase epsilon inhibitors exhibiting anti-osteoclastic activity | Bonsu Ku, Hye-Yeoung Yun, Kyung WonLee, Ho-Chul Shin, Sang-Rae Lee, Chang Hyen Kim, Hwangseo Park, Kyu Yang Yi, Chang Hoon Lee, Seung Jun Kim | Bioorganic & Medicinal Chemistry Letters2018, 26(18), 5204-5211 | 2018 | https://doi.org/10.1016/j.bmc.2018.09.022 |
| 3 | QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species | Byoung Sik Kim, Song Yee Jang, Ye-ji Bang, Jungwon Hwang, Youngwon Koo, Kyung Ku Jang, Dongyeol Lim, Myung Hee Kim, Sang Ho Choi | mBio2018, 9(1), e02262-17 | 2018 | http://dx.doi.org/10.1128/mBio.02262-17 |
| 4 | Design and Synthesis of Novel 3-(2-Aminopyridin-3-yl)-1,2,4-Triazolo[4,3-b]Pyridazine Derivatives as a Reversible Bruton’s Tyrosine Kinase Inhibitors | Chi Hoon Park, Dukwoon Kim, Hyeonseok Jung, Jeong Hee Jeon, Raghavendra Achary, Joo-Youn Lee, Pilho Kim, Heejung Jung, Jong Yeon Hwang, Do Hyun Ryu, Jae Du Ha, and Sung Yun Cho | Bulletin of the Korean Chemical Society2018, 온라인 게재 | 2018 | http://dx.doi.org/10.1002/bkcs.11485 |
| 5 | Restoring Let-7 microRNA Biogenesis Using a Small-Molecule Inhibitor of the Protein-RNA Interaction | Donghyun Lim, Wan Gi Byun, and Seung Bum Park | ACS Medicinal Chemistry Letters2018, 9(12), 1181-1185 | 2018 | https://doi.org/10.1021/acsmedchemlett.8b00323 |
| 6 | Identification and Characterization of NTB451 as a Potential Inhibitor of Necroptosis | Eun-Jung In, Yuno Lee, Sushruta Koppula, Tae-Yeon Kim, Jun-Hyuk Han, Kwang-Ho Lee, and Tae-Bong Kang | Molecules2018, 23(11), 2884-2899 | 2018 | https://doi.org/10.3390/molecules23112884 |
| 7 | Identification of quinone analogues as potential inhibitors of picornavirus 3C protease in vitro | Eunhye Jung, Joo-Youn Lee, Ho Jeong Kim, Chung-Kyu Ryu, Kee-In Lee, Meehyein Kim, Chong-Kyo Lee, Yun Young Go | Bioorganic & Medicinal Chemistry Letters2018, in press | 2018 | https://doi.org/10.1016/j.bmcl.2018.05.046 |
| 8 | A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes | Hyejin Lim, Yu-Mi Lim, Kook Hwan Kim, Young Eui Jeon, Kihyoun Park, Jinyoung Kim, Hui-Yun Hwang, Dong Jin Lee, Haushabhau Pagire, Ho Jeong Kwon, Jin Hee Ahn & Myung-Shik Lee | NATURE COMMUNICATIONS2018, 9, 1438 | 2018 | http://dx.doi.org/10.1038/s41467-018-03939-w |
| 9 | DBU-Promoted Dynamic Kinetic Resolution in Rh-Catalyzed Asymmetric Transfer Hydrogenation of 5-Alkyl Cyclic Sulfamidate Imines: Stereoselective Synthesis of Functionalized 1,2-Amino Alcohols | Hyeong Rae Kim, Raghavendra Achary, and Hyeon-Kyu Lee | Journal of Organic Chemistry2018, 83(19), 11987-11999 | 2018 | https://doi.org/10.1021/acs.joc.8b01892 |
| 10 | Reverting iodine avidity of radioactive-iodine refractory thyroid cancer with a new tyrosine kinase inhibitor (K905-0266) excavated by high-throughput NIS (sodium iodide symporter) enhancer screening platform using dual reporter gene system | Ji Min Oh, Senthilkumar Kalimuthu, Prakash Gangadaran, Se Hwan Baek, Liya Zhu, Ho Won Lee, Ramya Lakshmi Rajendran, Chae Moon Hong, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee and Byeong-Cheol Ahn | Oncotarget2018, 9(6), 7075-7087 | 2018 | http://dx.doi.org/10.18632/oncotarget.24159 |
| 11 | Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells | Ji-Hye Kim, Jun Mi Lee, Jong-Hoon Kim, Kwang Rok Kim | Biochemical and Biophysical Research Communications2018, 503(3), 1415-1421 | 2018 | https://doi.org/10.1016/j.bbrc.2018.07.057 |
| 12 | Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro | Jin Soo Shin, Eunhye Jung, Meehyein Kim, Ralph S. Baric and Yun Young Go | Viruses2018, 10, 283 | 2018 | http://dx.doi.org/10.3390/v10060283 |
| 13 | Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation | Jitendra Shrestha, Sung Hwan Ki, Sang Mi Shin, Seon Woong Kim, Joo-Youn Lee, Hee-Sook Jun, Taeho Lee, Sanghee Kim, Dong Jae Baek and Eun-Young Park | Molecules2018, 23(11), 2750-2761 | 2018 | https://doi.org/10.3390/molecules23112750 |
| 14 | Suppression of NRF2/ARE by convallatoxin sensitises A549 cells to 5-FU-mediated apoptosis | June Lee, Jong-Su Kang, Le Ba Nam, Ok-Kyung Yoo, and Young-Sam Keum | Free Radical Research2018, 온라인 게재 | 2018 | https://doi.org/10.1080/10715762.2018.1489132 |
| 15 | A pivotal role of AMPK signaling in medicarpin-mediated formation of Brown and Beige | Khan Mohammad Imran, Dahyeon Yoon, Yong-Sik Kim | BioFactors2018, 44(2), 168-179 | 2018 | http://dx.doi.org/10.1002/biof.1392 |
| 16 | A novel anti-melanogenic agent, KDZ-001, inhibits tyrosinase enzymatic activity | Kyu-Seok Hwang, Jung Yoon Yang, Jooyun Lee, Yu-Ri Lee, Seong Soon Kim, Geum Ran Kim, Jin Sil Chae, Jin Hee Ahn, Dae-Seop Shin, Tae-Young Choi, Myung Ae Bae | Journal of Dermatological Science2018, 89, 165-171 | 2018 | http://dx.doi.org/10.1128/mBio.02262-17 |
| 17 | Synthesis and biological evaluation of indazole-4,7-dione derivatives as novel BRD4 inhibitors | Minjin Yoo, Miyoun Yoo, Ji Eun Kim, Heung Kyoung Lee, Chong Ock Lee, Chi Hoon Park, Kwan-Young Jung | Archives of Pharmacal Research2018, 41(1), 46-56 | 2018 | http://dx.doi.org/10.1007/s12272-017-0978-y |
| 18 | Effects of a small molecule R-spondin-1 substitute RS-246204 on a mouse intestinal organoid culture | Myeong-Ok Nam, Soojung Hahn, Joo Hyun Jee, Tae-Sun Hwang, Ho Yoon, Dong Hyeon Lee, Min-Soo Kwon and Jongman Yoo | Oncotarget2018, 9(5), 6356-6368 | 2018 | http://dx.doi.org/10.18632/oncotarget.23721 |
| 19 | Tandem Rh-Catalyzed Oxidative C?H Olefination and Cyclization of Enantiomerically Enriched Benzo-1,3-Sulfamidates: Stereoselective Synthesis of trans-1,3-Disubstituted Isoindolines | Raghavendra Achary, In-A Jung, and Hyeon-Kyu Lee | Journal of Organic Chemistry2018, 83(7), 3864-3878 | 2018 | http://dx.doi.org/10.1021/acs.joc.8b00204 |
| 20 | Psoralidin Stimulates Expression of Immediate-Early Genes and Synapse Development in Primary Cortical Neurons | Seojin Hwang, Seong-eun Lee, Sang-Gun Ahn, Gum Hwa Lee | Neurochemical Research2018, 43(2), 2460-2472 | 2018 | https://link.springer.com/content/pdf/10.1007/s11064-018-2689-2.pdf |
| 21 | Mosquitocidal activity of penfluridol as juvenile hormone antagonist | Seok-Hee Lee, Hee Nam Lim, Jae Young Choi, Dong Hwan Park, Byung Hoon Ahn, Ying Fang, Jong Hoon Kim, Min Gu Park, Ra Mi Woo, Bo Ram Lee, Woo Jin Kim, Young Kwan Ko, Ill Young Lee, Yeon Ho Je | Journal of Asia-Pacific Entomology2018, 21, 130-133 | 2018 | https://doi.org/10.1016/j.aspen.2017.11.009 |
| 22 | Synthesis and Biological Evaluation of FTY720 (Fingolimod) Derivatives with Aromatic Head Group as Anticancer Agents | Taeho Lee, Hong Seop Moon, Seon Woong Kim, Jitendra Shrestha, Sang Mi Shin, Joo-Youn Lee, Sanghee Kim, Eun-Young Park, and Dong Jae Baek | Chemical and Pharmaceutical Bulletin2018, 66(10), 1015-1018 | 2018 | https://doi.org/10.1248/cpb.c18-00065 |
| 23 | Salinomycin Inhibits Influenza Virus Infection by Disrupting Endosomal Acidification and Viral Matrix Protein 2 Function | Yejin Jang, Jin Soo Shin, Yi-Seul Yoon, Yun Young Go, Hye Won Lee, Oh Seung Kwon, Sehee Park, Man-Seong Park, Meehyein Kim | Journal of Virology2018, 92(24), e01441-18 | 2018 | https://doi.org/10.1128/JVI.01441-18 |
| 24 | A natural compound, aristoyagonine, is identified as a potent bromodomain inhibitor by mid-throughput screening | Young Hun Kim, Minsung Kim, Miyoun Yoo, Ji Eun Kim, Heung Kyoung Lee, Jung-Nyoung Heo, Chong Ock Lee, Minjin Yoo, Kwan-Young Jung, Chang-Soo Yun, Sung Woong Moon, Hye Kyung Chang, Chul-Woong Chung, Suhkneung Pyo, Sang Un Choi, Chi Hoon Park | Biochemical and Biophysical Research Communications2018, 503, 882-887 | 2018 | https://doi.org/10.1016/j.bbrc.2018.06.091 |
| 25 | 실험용 항균성 불소바니쉬의 최소억제농도와 최소살균농도 | 손주리, 김아진, 오승한, 배지명 | Korean Journal of Dental Materials2018, 45(2), 139-146 | 2018 | http://dx.doi.org/10.14815/kjdm.2018.45.2.139 |
2017
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | Enterovirus inhibitory activity of C-8-tert-butyl substituted 4-aryl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-ones | Bishyajit Kumar Biswas, Yashwardhan R. Malpani, Neul Ha, Do-Hyun Kwon, Jin Soo Shin, Hae-Soo Kim, Chonsaeng Kim, Soo Bong Han, Chong-Kyo Lee, Young-Sik Jung | Bioorganic & Medicinal Chemistry Letters2017, 27, 3582-3585 | 2017 | http://dx.doi.org/10.1016/j.bmcl.2017.05.030 |
| 2 | 3-Amino-1H-pyrazolopyridine Derivatives as a Maternal Embryonic Leucine Zipper Kinase Inhibitor | Chul Min Park, Vithal B. Jadhav, Jong-Hwan Song, Sunkyung Lee, Hee Young Won, Sang Un Choi, and You Hwa Son | Bulletin of the Korean Chemical Society2017, 38(6), 595-602 | 2017 | http://dx.doi.org/10.1002/bkcs.11129 |
| 3 | KRICT-9 inhibits neuroinflammation, amyloidogenesis and memory loss in Alzheimer’s disease models | Do Yeon Lee, Chul Ju Hwang, Ji Yeon Choi, Mi Hee Park, Min Ji Song, Ki Wan Oh, Sang Bae Han, Woo Kyu Park, Hee Yeong Cho, Sung Yun Cho, Hye Byn Park, Min Jong Song and Jin Tae Hong | Oncotarget2017, 8(40), 68654-68667 | 2017 | http://dx.doi.org/10.18632/oncotarget.19818 |
| 4 | Synthesis and Molecular Modeling Studies of N’-Hydroxyindazolecarboximidamides as Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors | Dong-Ho Lee, Joo-Youn Lee, Jieun Jeong, Miok Kim, Kyung Won Lee, Eunseo Jang, Sunjoo Ahn, Chang Hoon Lee and Jong Yeon Hwang | Molecules2017, 22, 1936-1945 | 2017 | https://doi.org/10.3390/molecules22111936 |
| 5 | A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer | E-J Choi, B-J Jung, S-H Lee, H-S Yoo, E-A Shin, H-J Ko, S Chang, S-Y Kim and S-M Jeon | Oncogene2017, 36, 5285-5295 | 2017 | http://dx.doi.org/10.1038/onc.2017.153 |
| 6 | Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors | Eun-Jin Han, Hyun Young Kim, Naeun Lee, Nam-Hoon Kim, Seung-Ah Yoo, H. Moo Kwon, Dae-Myung Jue, Yune-Jung Park, Chul-Soo Cho, Tran Quang De, Dae Young Jeong, Hee-Jong Lim, Woo Kyu Park, Ge Hyeong Lee, Heeyeong Cho, Wan-Uk Kim | EBioMedicine2017, 18, 261-273 | 2017 | http://dx.doi.org/10.1016/j.ebiom.2017.03.039 |
| 7 | Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R | Gangadhar Rao Mathi, Chung Hyo Kang, Heung Kyoung Lee, Raghavendra Achary, Ha-Yeon Lee, Joo-Youn Lee, Jae Du Ha, Sunjoo Ahn, Chi Hoon Park, Chong Ock Lee, Jong Yeon Hwang, Chang-Soo Yun, Hee Jung Jung, Sung Yun Cho, Hyoung Rae Kim, Pilho Kim | European Journal of Medicinal Chemistry2017, 126, 536-549 | 2017 | http://dx.doi.org/10.1016/j.ejmech.2016.11.046 |
| 8 | The Discovery of Novel Protein Tyrosine Phosphatase ε Inhibitors Using a High-throughput Screening Approach | Hye-Yeoung Yun, Bonsu Ku, Hye Seon Lee, Ho-Chul Shin, Jun-Beom Park, Chang Hyen Kim, and Seung Jun Kim | Bulletin of the Korean Chemical Society2017, 38, 44-53 | 2017 | http://dx.doi.org/10.1002/bkcs.11044 |
| 9 | Design and Synthesis of Novel Pyrazolo[3,4-d]pyrimidin-1-yl piperidine Derivatives as Bruton’s Tyrosine Kinase Inhibitors | Hyebin Park, Chi Hoon Park, Seung-Tae Kang, Jeong Hee Jeon, Raghavendra Archary, Joo-Youn Lee, Pilho Kim, Heejung Jung, Chang-Soo Yun, Jong Yeon Hwang, Do Hyun Ryu, and Sung Yun Cho | Bulletin of the Korean Chemical Society2017, 38, 278-281 | 2017 | http://dx.doi.org/10.1002/bkcs.11065 |
| 10 | An Efficient Copper-catalyzed Nucleophilic Addition to N-Acyliminium Ions Derived from N-Benzyloxycarbonylamino Sulfones: A Novel Approach to C-3 Functionalization of 2-Phenylimidazo[1,2-a]pyridine | Hyeong Jin Park and Jong-Gab Jun | Bulletin of the Korean Chemical Society2017, 38, 1123-1128 | 2017 | http://dx.doi.org/10.1002/bkcs.11228 |
| 11 | Identification of Antipneumococcal Molecules Effective Against Different Streptococcus pneumoniae Serotypes Using a Resazurin-Based High-Throughput Screen | Hyung Jun Kim, Namyoul Kim, David Shum, Srigouri Huddar, Chul Min Park, and Soojin Jang | ASSAY and Drug Development Technologies2017, 15(5), 198-209 | 2017 | http://dx.doi.org/10.1089/adt.2017.789 |
| 12 | BET Inhibitors as Anticancer Agents : A Patent Review | Imran Ali, Gildon Choi and Kwangho Lee | Recent Patents on Anti-Cancer Drug Discovery2017, 12, 340-364 | 2017 | https://doi.org/10.2174/1574892812666170808121228 |
| 13 | Discovery of novel [1,2,4]triazolo[4,3-a]quinoxaline aminophenyl derivatives as BET inhibitors for cancer treatment | Imran Ali, Jooyun Lee, Areum Go, Gildon Choi, Kwangho Lee | Bioorganic & Medicinal Chemistry Letters2017, 27, 4606-4613 | 2017 | http://dx.doi.org/10.1016/j.bmcl.2017.09.025 |
| 14 | A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication | Jinwoo Kim, Yu Kyoung Jung, Chonsaeng Kim, Jin Soo Shin, Els Scheers, Joo-Youn Lee, Soo Bong Han, Chong-Kyo Lee, Johan Neyts, Jae-Du Ha, and Young-Sik Jung | Journal of Medicinal Chemistry2017, 60, 5472-5492 | 2017 | http://dx.doi.org/10.1021/acs.jmedchem.7b00175 |
| 15 | Identification of novel ALK2 inhibitors and their effect on cancer cells | Minsung Kim, Okran Choi, Suhkneung Pyo, Sang Un Choi, Chi Hoon Park | Biochemical and Biophysical Research Communications2017, 492, 121-127 | 2017 | http://dx.doi.org/10.1016/j.bbrc.2017.08.016 |
| 16 | Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cells | Myeong-ok Kim, Min Ho Choe, Yi Na Yoon, Jiyeon Ahn, Minjin Yoo, Kwan-Young Jung, Sungkwan An, Sang-Gu Hwang, Jeong Su Oh, Jae-Sung Kim | Biochemical Pharmacology2017, 144(15), 78-89 | 2017 | http://dx.doi.org/10.1016/j.bcp.2017.08.009 |
| 17 | Synthesis of Fluorescent Indazoles by Palladium-Catalyzed Benzannulation of Pyrazoles with Alkynes | Og Soon Kim, Jin Hyeok Jang, Hyun Tae Kim, Su Jin Han, Gavin Chit Tsui, and Jung Min Joo | Organic Letters2017, 19(6), 1450-1453 | 2017 | http://dx.doi.org/10.1021/acs.orglett.7b00410 |
| 18 | Stereoselective Synthesis of Functionalized 1, 3-Disubstituted Isoindolines via Rh(III)-Catalyzed Tandem Oxidative Olefination-Cyclization of 4-Aryl-cyclic Sulfamidate-5-Carboxylates | Raghavendra Achary, In-A Jung, Se-Mi Son, and Hyeon-Kyu Lee | The Journal of Organic Chemistry2017, 82, 7223-7233 | 2017 | http://dx.doi.org/10.1021/acs.joc.7b00799 |
| 19 | Antimicrobial activity of novel 4H-4-oxoquinolizine compounds against extensively drug-resistant Acinetobacter baumannii strains | Seok Hyeon Na, Hyejin Jeon, Yoo Jeong Kim, Hyo Il Kwon, Gati Noble Selasi, Asiimwe Nicholas, Chang-Soo Yun, Sang Ho Lee, Je Chul Lee | International Journal of Antimicrobial Agents2017, 49, 107-111 | 2017 | http://dx.doi.org/10.1016/j.ijantimicag.2016.10.008 |
| 20 | Development of an HTS system to identify natural chemicals that specifically inhibit Escherichia coli O157:H7 adhesion to host cells | Seung Min Kim, Hyun Jung Kim | Food Control2017, 73, 185-192 | 2017 | http://dx.doi.org/10.1016/j.foodcont.2016.08.007 |
| 21 | Activity of novel inhibitors of Staphylococcus aureus biofilms | Seung-Gyun Woo, So-Yeon Lee, So-Min Lee, Kyoung-Hee Lim, Eun-Ju Ha, Yong-Bin Eom | Folia Microbiologica2017, 62(2), 157-167 | 2017 | http://dx.doi.org/10.1007/s12223-016-0485-4 |
| 22 | Acceleration of osteoblast differentiation by a novel osteogenic compound, DMP-PYT, through activation of both the BMP and Wnt pathways | Su Jung Bae, Hye Joo Kim, Hee Yeon Won, Yong Ki Min and Eun Sook Hwang | Scientific Reports2017, 7, 8455-8464 | 2017 | http://dx.doi.org/10.1038/s41598-017-08190-9 |
| 23 | Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors | Sun Jun Park, Eunjin Kim, Miyoun Yoo, Joo-Youn Lee, Chi Hoon Park, Jong Yeon Hwang, Jae Du Ha | Bioorganic & Medicinal Chemistry Letters2017, 27(18), 4399-4404 | 2017 | http://dx.doi.org/10.1016/j.bmcl.2017.08.018 |
| 24 | Development of a High-Throughput Assay for Inhibitors of the Polo-Box Domain of Polo-Like Kinase 1 Based on Time-Resolved Fluorescence Energy Transfer | Tae Gi Kim, Ju Hee Lee, Mi Young Lee, Ka-Ul Kim, Jeong Hyun Lee, Chi Hoon Park, Byung Ho Lee, and Kwang-Seok Oh | Biological and Pharmaceutical Bulletin2017, 40(9), 1454-1462 | 2017 | http://doi.org/10.1248/bpb.b17-00283 |
| 25 | Anti-cancer effect of novel PAK1 inhibitor via induction of PUMAmediated cell death and p21-mediated cell cycle arrest | Tae-Gyun Woo, Min-Ho Yoon, Shin-Deok Hong, Jiyun Choi, Nam-Chul Ha, Hokeun Sun, Bum-Joon Park | Oncotarget2017, 8(14), 23690-23701 | 2017 | http://dx.doi.org/10.18632/oncotarget.15783 |
| 26 | Naphthofuroquinone derivatives show strong antimycobacterial activities against drug-resistant Mycobacteria | Woong Sik Jang, Young-Sang Choi, Sukyung Kim, Md. Anirban Jyoti, Hoonhee Seo, Juhye Han, Yong-Sik Kim, Jiwon Lyu, Kung-Woo Nam, Byung-Eui Lee, Kee-In Lee & Ho-Yeon Song | Journal of Chemotherapy2017, 29(6), 338-343 | 2017 | http://dx.doi.org/10.1080/1120009X.2017.1296987 |
| 27 | On-Chip Peptide Mass Spectrometry Imaging for Protein Kinase Inhibitor Screening | Young-Lai Cho, Young-Pil Kim, Jin Gyeong Son, Miyoung Son, and Tae Geol Lee | Analytical Chemistry2017, 89, 799-806 | 2017 | http://dx.doi.org/10.1021/acs.analchem.6b03557 |
2016
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression | Ah-Young Oh, Youn Sang Jung, Jiseon Kim, Jee-Hyun Lee, Jung-Hyun Cho, Ho-Young Chun, Soyoung Park, Hyunchul Park, Sikeun Lim, Nam-Chul Ha, Jong Sook Park, Choon-Sik Park, Gyu-Yong Song, and Bum-Joon Park | Cancer Research2016, 76(16), 4791-4804 | 2016 | http://dx.doi.org/10.1158/0008-5472.CAN-15-1025 |
| 2 | Dihydroergotamine Tartrate Induces Lung Cancer Cell Death through Apoptosis and Mitophagy | Chang S.-H., Lee A.Y., Yu K.-N., Park J., Kim K.P., Cho M.-H. | Chemotherapy2016, 61(6), 304-312 | 2016 | http://dx.doi.org/10.1159/000445044 |
| 3 | Minor modifications to ceritinib enhance anti-tumor activity in EML4-ALK positive cancer | Chung Hyo Kang, Eun-Young Kim, Hyoung Rae Kim, Chong Ock Lee, Heung Kyoung Lee, Hye Gwang Jeong, Sang Un Choi, Chang-Soo Yun, Jong Yeon Hwang, Joo-Youn Lee, You Hwa Son, Sunjoo Ahn, Byung Hoi Lee, Heejung Jung, Chi Hoon Park | Cancer Letters2016, 374, 272-278 | 2016 | http://dx.doi.org/10.1016/j.canlet.2016.02.009 |
| 4 | Novel 2,4-diaminopyrimidines bearing tetrahydronaphthalenyl moiety against anaplastic lymphoma kinase (ALK): Synthesis, in vitro, ex vivo, and in vivo efficacy studies | Dawn Song, Minji Lee, Chi Hoon Park, Sunjoo Ahn, Chang Soo Yun, Chong Ock Lee, Hyoung Rae Kim, Jong Yeon Hwang | Bioorganic & Medicinal Chemistry Letters2016, 26, 1720-1725 | 2016 | http://dx.doi.org/10.1016/j.bmcl.2016.02.052 |
| 5 | DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression | Dong Wha Jun, Mihwa Hwang, Yun-Hee Kim, Kyung-Tae Kim, Sunshin Kim and Chang-Hun Lee | Oncotarget2016 | 2016 | http://dx.doi.org/10.18632/oncotarget.7135 |
| 6 | Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain | Duk-Joong Kim, Chang-Ki Choi, Chan-Soo Lee, Mee-Hee Park, Xizhe Tian, Nam Doo Kim, Kee-In Lee, Joong-Kwon Choi, Jin Hee Ahn, Eun-Young Shin, Injae Shin and Eung-Gook Kim | Experimental & Molecular Medicine2016, 48, e229 | 2016 | http://dx.doi.org/10.1038/emm.2016.13 |
| 7 | A Dual Readout Assay Based on Fluorescence Polarization and Time-Resolved Fluorescence Resonance Energy Transfer to Screen for RSK1 Inhibitors | Eun-mi Jeong, Mi Young Lee, Jeong Hyun Lee, Byung Ho Lee, Kwang-Seok Oh | Biological and Pharmaceutical Bulletin (Japan)2016, 39, 547-555 | 2016 | http://dx.doi.org/10.1248/bpb.b15-00808 |
| 8 | Identification of novel protein tyrosine phosphatase sigma inhibitors promoting neurite extension | Hye Seon Lee, Bonsu Ku, Tae Hyun Park, Hwangseo Park, Joong-Kwon Choi, Kyu-Tae Chang, Cheol-Hee Kim, Seong Eon Ryu, Seung Jun Kim | Bioorganic & Medicinal Chemistry Letters2016, 26(1), 87-93 | 2016 | http://www.sciencedirect.com/science/article/pii/S0960894X15302341 |
| 9 | Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy | Hyun-Yi Kim, Sehee Choi, Ji-Hye Yoon, Hwan Jung Lim, Hyuk Lee, Jiwon Choi, Eun Ji Ro, Jung-Nyoung Heo, Weontae Lee, Kyoung Tai No & Kang-Yell Choi | EMBO Molecular Medicine2016 | 2016 | http://dx.doi.org/10.15252/emmm.201505714 |
| 10 | Development of potent chemical antituberculosis agents targeting Mycobacterium tuberculosis acetohydroxyacid synthase | In-Pil Jung, Na-Reum Ha, Sang-Choon Lee, Sung-Weon Ryoo, Moon-Young Yoon | International Journal of Antimicrobial Agents2016, 48, 247-258 | 2016 | http://dx.doi.org/10.1016/j.ijantimicag.2016.04.031 |
| 11 | Calcium-chelating alizarin and other anthraquinones inhibit biofilm formation and the hemolytic activity of Staphylococcus aureus | Jin-Hyung Lee, Yong-Guy Kim, Shi Yong Ryu, Jintae Lee | Scientific Reports2016, 1, 864 | 2016 | http://dx.doi.org/10.1038/srep19267 |
| 12 | IinQ attenuates systemic inflammatory responses via selectively impairing the Myddosome complex formation upon TLR4 ligation | Kidong Kang†, Minho Won†, Jae-Min Yuk†, Chan-Yong Park, Hee Sun Byun, Kyeong Ah Park, So-Ra Lee, Young-Goo Kang, Han-Ming Shen, Ill Young Lee, Gang Min Hur | Biochemical Pharmacology2016, 121, 52-66 | 2016 | http://dx.doi.org/10.1016/j.bcp.2016.09.017 |
| 13 | Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study | Minju Kim, Sunhoe Lee, Eun Beul Park, Kwang Jong Kim, Hwi Ho Lee, Ji-Sun Shin, Katrin Fischer, Andreas Koeberle, Oliver Werz, Kyung-Tae Lee, Jae Yeol Lee | Bioorganic & Medicinal Chemistry Letters2016, 26(1), 94-99 | 2016 | http://www.sciencedirect.com/science/article/pii/S0960894X1530233X |
| 14 | Chromo/Fluorogenic Detection of Co2+, Hg2+ and Cu2+ by the Simple Schiff Base Sensor | Muhammad Saleem, Chung Ho Khang, Moon-Hwan Kim, Ki Hwan Lee | Journal of Fluorescence – RAPID COMMUNICATION2016, 26(1), 11-22 | 2016 | http://link.springer.com/article/10.1007/s10895-015-1723-x |
| 15 | Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening | Myoung Eun Jung, Byung Jin Byun, Hye-Mi Kim, Joo Yun Lee, Jin-Hee Park, Nari Lee, You Hwa Son, Sang Un Choi, Kyung-Min Yang, Seong-Jin Kim, Kwangho Lee, Yong-Chul Kim, Gildon Choi | Bioorganic & Medicinal Chemistry Letters2016, 26(11), 2719-2723 | 2016 | http://dx.doi.org/10.1016/j.bmcl.2016.03.111 |
| 16 | Stereoselective synthesis of 1,3-disubstituted isoindolines via Rh(III)-catalyzed tandem oxidative olefination-cyclization of 4-aryl cyclic sulfamidates | Se-Mi Son, Yeon Ji Seo, and Hyeon-Kyu Lee | ChemComm2016, 52, 4286-4289 | 2016 | http://dx.doi.org/10.1039/c5cc09888b |
| 17 | Activity of novel inhibitors of Staphylococcus aureus biofilms | Seung-Gyun Woo, So-Yeon Lee, So-Min Lee, Kyoung-Hee Lim, Eun-Ju Ha, Yong-Bin Eom | Folia Microbiologica2016, 61, 1-11 | 2016 | http://dx.doi.org/10.1007/s12223-016-0485-4 |
| 18 | Urinary Bladder-Relaxant Effect of Kurarinone Depending on Potentiation of Large-Conductance Ca2+-Activated K+ Channels | Sojung Lee, Mee Ree Chae, Byoung-Cheol Lee, Yong-Chul Kim, Jae Sue Choi, Sung Won Lee, Jae Hoon Cheong, and Chul-Seung Park | Molecular Pharmacology2016, in press | 2016 | http://dx.doi.org/10.1124/mol.115.102939 |
| 19 | Interruption of progerin.lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype | Su-Jin Lee, Youn-Sang Jung, Min-Ho Yoon, So-mi Kang, Ah-Young Oh, Jee-Hyun Lee, So-Young Jun, Tae-Gyun Woo, Ho-Young Chun, Sang Kyum Kim, Kyu Jin Chung, Ho-Young Lee, Kyeong Lee, Guanghai Jin, Min-Kyun Na, Nam Chul Ha, Clea Barcena, Jose M.P. Freije, Carlos Lopez-Otin, Gyu Yong Song and Bum-Joon Park | Journal of Clinical Investigation2016, 126(10), 3879-3893 | 2016 | http://dx.doi.org/10.1172/JCI84164 |
| 20 | Novel 3-amino-7-(aminomethyl)-1H-indazol-4-ol as the PI3Kγ enzyme inhibitor | Sukumar Bepary, In Kwon Yoon, and Ge Hyeong Lee | Bulletin of the Korean Chemical Society2016, 37, 2054-2057 | 2016 | http://dx.doi.org/10.1002/bkcs.10994 |
| 21 | Peptide inhibition of p22phox and Rubicon interaction as a therapeutic strategy for septic shock | Ye-Ram Kim, Hyun-Jung Koh, Jae-Sung Kim, Jin-Seung Yun, Kiseok Jang, Joo-Youn Lee, Jae U. Jung, Chul-Su Yang | Biomaterials2016, 101, 47-59 | 2016 | http://dx.doi.org/10.1016/j.biomaterials.2016.05.046 |
| 22 | Diacetoxyscirpenol as a new anticancer agent to target hypoxiainducible factor 1 | Yong-Joon Choi, Hyun-Woo Shin, Yang-Sook Chun, Alain Simplice Leutou, Byeng Wha Son, Jong-Wan Park | Oncotarget2016, 7(38), 62107-62122 | 2016 | http://dx.doi.org/10.18632/oncotarget.11529 |
| 23 | Identification of Mitotic Blockers by Phenotypic Screening of a Clinical Compound Library | You Hwa Son, Chi Hoon Park, and Sang Un Choi | Bulletin of the Korean Chemical Society2016, 37, 1942-1946 | 2016 | http://dx.doi.org/10.1002/bkcs.10999 |
| 24 | Identification of a New Morpholine Scaffold as a P2Y12 Receptor Antagonist | Young Ha Ahn†, Joo-Youn Lee†, Hee Dong Park, Tae Hun Kim, Min Chul Park, Gildon Choi and Sunghoon Kim | Molecules2016, 21, 1114-1124 | 2016 | http://dx.doi.org/10.3390/molecules21091114 |
| 25 | Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection | Young Ha Ahn†, Sunyoung Park†, Jeong June Choi, Bo-Kyung Park, Kyung Hee Rhee, Eunjoo Kang, Soyeon Ahn, Chul-Ho Lee, Jong Soo Lee, Kyung-Soo Inn, Mi-La Cho, Sung-Hwan Park, Kyunghee Park, Hae Jung Park, Jae Hyun Lee, Jung Won Park, Nam Hoon Kwon, Hyunbo Shim, ByungWoo Han, Pilhan Kim, Joo-Youn Lee, Youngho Jeon, Jin Won Huh, Mirim Jin and Sunghoon Kim | Nature Microbiology2016, 2, 1-12 | 2016 | http://dx.doi.org/10.1038/NMICROBIOL.2016.191 |
| 26 | Selective and Efficient Elimination of Vibrio cholerae with a Chemical Modulator that Targets Glucose Metabolism | Young Taek Oh, Hwa Young Kim, Eun Jin Kim, Junhyeok Go, Wontae Hwang, Hyoung Rae Kim, Dong Wook Kim and Sang Sun Yoon | Frontiers in Cellular and Infection Microbiology2016, 6, 156 | 2016 | http://dx.doi.org/10.3389/fcimb.2016.00156 |
2015
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor | Ga Ae Kang, Minji Lee, Dawn Song, Heung Kyoung Lee, Sunjoo Ahn, Chi Hoon Park, Chong Ock Lee, Chang Soo Yun, Heejung Jung, Pilho Kim, Jae Du Ha, Sung Yun Cho, Hyoung Rae Kim, Jong Yeon Hwang | Bioorganic & Medicinal Chemistry Letters2015, 25(18), 3992-3998 | 2015 | http://www.sciencedirect.com/science/article/pii/S0960894X15007088 |
| 2 | Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor | Hyeon Young Kim, Vithal B. Jadhav, Dae Young Jeong, Woo Kyu Park, Jong-Hwan Song, Sunkyung Lee, Heeyeong Cho | Archives of Pharmacal Research2015, 38, 1019-1032 | 2015 | http://link.springer.com/article/10.1007/s12272-015-0560-4 |
| 3 | Praeruptorin A Inhibits in Vitro Migration of Preosteoclasts and in Vivo Bone Erosion, Possibly Due to Its Potential To Target Calmodulin | Jeong-Tae Yeon, Sik-Won Choi, Byung Jun Ryu, Kwang-Jin Kim, Joo Yun Lee, Byung Jin Byun, Young-Jin Son and Seong Hwan Kim | Journal of Natural Products2015, 78, 776-782 | 2015 | http://pubs.acs.org/doi/abs/10.1021/np501017z |
| 4 | A lipophilic fluorescent LipidGreen1-based quantification method for high-throughput screening analysis of intracellular poly-3-hydroxybutyrate | Ji Eun Choi, Hye Young Na, Taek Ho Yang, Sung-Keun Rhee and Jae Kwang Song | AMB Express2015, 5, 482015, 5, 48 | 2015 | http://www.amb-express.com/content/5/1/48 |
| 5 | An indoxyl compound 5-bromo-4-chloro-3-indolyl 1,3-diacetate, CAC-0982, suppresses activation of Fyn kinase in mast cells and IgE-mediated allergic responses in mice | Jun Ho Lee, Tae Hyung Kim, Hyuk Soon Kim, A-Ram Kim, Do-Kyun kim, Seung Taek Nam, HyunWoo Kim, Young Hwan Park, Erk Her, Yeong Min Park, Hyung Sik Kim, Young Mi Kim, Wahn Soo Choi | Toxicology and Applied Pharmacology2015, 285(3), 179-186 | 2015 | http://www.sciencedirect.com/science/article/pii/S0041008X15001398 |
| 6 | Synthesis of 4-(3,4-dicarboxamido-1H-pyrrole)pyrimidines as Anaplastic Lymphoma Kinase Inhibitors | Muhammad Latif, Byung Jin Byun and Kwangho Lee | Bulletin of the Korean Chemical Society2015, 36(2), 520-525 | 2015 | https://onlinelibrary.wiley.com/doi/full/10.1002/bkcs.10097 |
| 7 | Design, Synthesis, and Evaluation of 2-Anilino-4-(3,5-dicarbox- amidespiperidine)-pyrimidines as Anaplastic Lymphoma Kinase Inhibitors | Muhammad Latif, Sangjun Park, Imran Ali, Hyeonjeong Choe, Chong Hak Chae, Chi Hoon Park, Hyoung Rae Kim, Chang-Soo Yun and Kwangho Lee | Bulletin of the Korean Chemical Society2015, 36(2), 2397-2400 | 2015 | http://onlinelibrary.wiley.com/doi/10.1002/bkcs.10454/abstract;jsessionid=6E868AC9024F2D91A18E2354099C25F1.f03t04 |
| 8 | Quinoline Compound KM11073 Enhances BMP-2-Dependent Osteogenic Differentiation of C2C12 Cells via Activation of p38 Signaling and Exhibits In Vivo Bone Forming Activity | Seung-hwa Baek, Sik-Won Choi, Sang-Joon Park, Sang-Han Lee, Hang-Suk Chun, Seong Hwan Kim | PLOS ONE2015, 10(3): e0120150 | 2015 | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120150 |
| 9 | Identification of a novel 11β-HSD1 inhibitor from a high-throughput screen of natural product extracts | Sung Bum Park, Ji Seon Park, Won Hoon Jung, AReum Park, Sae Rom Jo, Hee Youn Kim, Sang Dal Rhee, Shi Yong Ryu, Hye Gwang Jeong, Seongsoon Park, Hyuk Lee, Ki Young Kim | Pharmacological Research2015, 102, 245-253 | 2015 | http://www.sciencedirect.com/science/article/pii/S1043661815002571 |
| 10 | Stereoselective Synthesis of 4-Substituted Cyclic Sulfamidate-5-Phosphonates by Using Rh-Catalyzed, Asymmetric Transfer Hydrogenation with Accompanying Dynamic Kinetic Resolution | Yeon Ji Seo, Jin-ah Kim, and Hyeon-Kyu Lee | The Journal of Organic Chemistry2015, 80(17), 8887-8902 | 2015 | http://pubs.acs.org/doi/10.1021/acs.joc.5b01434 |
| 11 | Synthesis and anti-tubercular activity of 2-nitroimidazooxazines with modification at the C-7 position as PA-824 analogs | Young-Goo Kang, Chan-Yong Park, Hongsuk Shin, Ramandeep Singh, Garima Arora, Chan-mo Yu, Ill Young Lee | Bioorganic & Medicinal Chemistry Letters2015, 25(17), 3650-3653 | 2015 | http://www.sciencedirect.com/science/article/pii/S0960894X15006538 |
2014
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | Discovery and the structural basis of a novel p21-activated kinase 4 inhibitor | Byung Jun Ryu, Sunmin Kim, Bora Min, Keon Young Kim, Jin Soo Lee, Whui Jung Park, Hyuk Lee, Seong Hwan Kim, Sang Youn Park | Cancer Letters2014, 349(1), 45-50 | 2014 | https://doi.org/10.1016/j.canlet.2014.03.024 |
| 2 | 4-Substituted quinazoline derivatives as novel EphA2 receptor tyrosine kinase inhibitors | Chae Jo Lim, Kwang-Seok Oh, Jae Du Ha, Jeong Hyun Lee, Ho Won Seo, Chong Hack Chae, Dae-Ghon Kim, Mi-Jin Lee, Byung Ho Lee | Bioorganic & Medicinal Chemistry Letters2014, 24, 4080-4083 | 2014 | https://doi.org/10.1016/j.bmcl.2014.07.081 |
| 3 | Identification of a series of 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl) pyridin-2-amines, as a new class of G-protein-coupled receptor kinase 2 and 5 inhibitor | Cheon Ho Park, Mi Young Lee, Jeong Hyun Lee, Byung Ho Lee, Kwang-seok Oh | Receptors & Clinical Investigation2014, 1(4), 112-114 | 2014 | http://dx.doi.org/10.1172/JCI200524178 |
| 4 | Inhibition of STAT3 activation by KT-18618 via the disruption of the interaction between JAK3 and STAT3 | Dae-Seop Shin, Seung Nam Jung, Jieun Yun, Chang Woo Lee, Dong Cho Han, BumTae Kim, Yong Ki Min, Nam Sook Kang, Byoung-Mog Kwon | Biochemical Pharmacology2014, 89(1), 62-73 | 2014 | https://doi.org/10.1016/j.bcp.2014.02.017 |
| 5 | 6-Trifluoromethyl-2-thiouracil possesses anti-Toxoplasma gondii effect in vitro and in vivo with low hepatotoxicity | Hwa-Jung Choi, Seung-Taek Yu, Kee-In Lee, Joong-Kwon Choi, Bo-Yoon Chang, Sung-Yeon Kim, Mi-Hwa Ko, Hyun-Ok Song, Hyun Park | Experimental Parasitology2014, 143, 24-29 | 2014 | https://doi.org/10.1016/j.exppara.2014.05.002 |
| 6 | ALK inhibitors of bis-ortho-alkoxy-para-piperazinesubstituted-pyrimidines and -triazines for cancer treatment | Hyeon Ji Lee, Muhammad Latif, Hyeonjeong Choe, Imran Ali, Heung Kyoung Lee, Eun Hye Yang, Jeong In Yun, Chong Hak Chae, Jae-Kyung Jung, Hyoung Rae Kim, Chong Ock Lee, Chi Hoon Park, Kwangho Lee | Archives of Pharmacal Research2014 | 2014 | https://doi.org/10.1007/s12272-013-0323-z |
| 7 | 6-Methoxyflavone Inhibits NFAT Translocation into the Nucleus and Suppresses T Cell Activation | Jae-Seon So, Gi-Cheon Kim, Minkyung Song, Choong-Gu Lee, Eunbee Park, Ho Jin Kim, Young Sup Kim, Chang-Duk Jun and Sin-Hyeog Im | The Journal of Immunology2014, 193(6), 2772-2783 | 2014 | https://doi.org/10.4049/jimmunol.1400285 |
| 8 | Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors | Jimin Woo, Hyun-Young Kim, Byung Jin Byun, Chong-Hak Chae, Ji Young Lee, Shi Yong Ryu, Woo-Kyu Park, Heeyeong Cho, Gildon Choi | Bioorganic & Medicinal Chemistry Letters2014, 24(11), 2486-2492 | 2014 | https://doi.org/10.1016/j.bmcl.2014.04.010 |
| 9 | Stereoselective synthesis of 4-substituted-cyclic sulfamidate-5-carboxylates by asymmetric transfer hydrogenation accompanied by dynamic kinetic resolution and applications to concise stereoselective syntheses of (-)-epi-cytoxazone and the taxotere side-chain | Jin-ah Kim, Yeon Ji Seo, Soyeong Kang, Juae Han and Hyeon-Kyu Lee | Chem. Commun.2014, 50, 13706-13709 | 2014 | https://doi.org/10.1039/C4CC06395C |
| 10 | Coumarins reduce biofilm formation and the virulence ofEscherichia coli O157:H7 | Jin-Hyung Lee, Yong-Guy Kim, Hyun Seob Cho, Shi Yong Ryu, Moo Hwan Cho, Jintae Lee | Phytomedicine2014, 21, 1037-1042 | 2014 | https://doi.org/10.1016/j.phymed.2014.04.008 |
| 11 | Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli O157:H7 and Staphylococcus aureus biofilm formation | Jin-Hyung Lee, Yong-Guy Kim, Shi Yong Ryu, Moo Hwan Cho, Jintae Lee | International Journal of Food Microbiology2014, 174, 47-55 | 2014 | https://doi.org/10.1016/j.ijfoodmicro.2013.12.030 |
| 12 | Resveratrol Oligomers Inhibit Biofilm Formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa | Jin-Hyung Lee, Yong-Guy Kim, Shi Yong Ryu, Moo Hwan Cho, Jintae Lee | Journal of Natural Products2014, 77(1), 168-172 | 2014 | https://doi.org/10.1021/np400756g |
| 13 | Stilbenes Reduce Staphylococcus aureus Hemolysis, Biofilm Formation, and Virulence | Lee Kayeon, Lee Jin-Hyung, Ryu Shi Yong, Cho Moo Hwan, and Lee Jintae | Foodborne Pathogens and Disease2014, 11(9), 710-717 | 2014 | https://doi.org/10.1089/fpd.2014.1758 |
| 14 | Dynamic Kinetic Resolution Based Asymmetric Transfer Hydrogenation of α.Alkoxy-β-Ketophosphonates. Diastereo- and Enantioselective Synthesis of Monoprotected 1,2-Dihydroxyphosphonates | Se-Mi Son and Hyeon-Kyu Lee | The Journal of Organic Chemistry2014, 79, 2666-2681 | 2014 | https://doi.org/10.1021/jo500148j |
| 15 | Discovery of substituted 6-pheny-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitors | Seung-Tae Kang, Eun-Young Kim, Raghavendra Archary, Heejung Jung, Chi Hoon Park, Chang-Soo Yun, Jong Yeon Hwang, Sang Un Choi, Chonghak Chae, Chong Ock Lee, Hyoung Rae Kim, Jae Du Ha, Dohyun Ryu, Sung Yun Cho | Bioorganic & Medicinal Chemistry Letters2014, 24, 5093-5097 | 2014 | https://doi.org/10.1016/j.bmcl.2014.08.067 |
| 16 | Synthesis and anti-influenza virus activity of 4-oxo- or thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-ones | Ye Jin Jang, Raghavendra Achary, Hye Won Lee, Hyo Jin Lee, Chong-Kyo Lee, Soo Bong Han, Young-Sik Jung, Nam Sook Kang, Pilho Kim, Meehyein Kim | Antiviral Research2014, 107, 66-75 | 2014 | https://doi.org/10.1016/j.antiviral.2014.04.013 |
| 17 | Xanthene Derivatives Increase Glucose Utilization through Activation of LKB1-Dependent AMP-Activated Protein Kinase | Yonghoon Kwon, Parkyong Song, Jong Hyuk Yoon, Jaewang Ghim, Dayea Kim, Byungjun Kang, Taehoon G. Lee, Jin-Ah Kim, Joong-Kwon Choi, In Kwon Youn, Hyeon-Kyu Lee, Sung Ho Ryu | PLOS One2014, 9(9), e108771 | 2014 | https://doi.org/10.1371/journal.pone.0108771 |
2013
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | Novel bis-ortho-alkoxy-para-piperazinesubstituted-2, 4-dianilinopyrimidines (KRCA-0008) as potent and selective ALK inhibitors for anticancer treatment | Chi Hoon Park, Hyeonjeong Choe, In-Young Jang, So Yeong Kwon, Muhammad Latif, Heung Kyoung Lee, Hyeon Ji Lee, Eun Hye Yang, Jeong In Yun, Chong Hak Chae, Sung Yun Cho, Sang Un Choi, Jae Du Ha, Heejung Jung, Hyoung Rae Kim, Pilho Kim, Chong Ock Lee, Chang-Soo Yun, Kwangho Lee | Bioorganic & Medicinal Chemistry Letters2013, 23(22), 6192-6196 | 2013 | https://doi.org/10.1016/j.bmcl.2013.08.090 |
| 2 | Elicitation of Induced Resistance against Pectobacterium carotovorum and Pseudomonas syringae by Specific Individual Compounds Derived from Native Korean Plant Species | Geun Cheol Song, Shi Yong Ryu, Young Sup Kim, Ji Young Lee, Jung Sup Choi and Choong-Min Ryu | Molecules2013, 18, 12877-12895 | 2013 | https://doi.org/10.3390/molecules181012877 |
| 3 | Identification of Novel Irreversible Inhibitors of UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) from Haemophilus influenzae | Han SG, Lee WK, Jin BS, Lee KI, Lee HH, Yu YG | Journal of Microbiology Biotechnology2013, 23(3), 329-334 | 2013 | https://doi.org/10.4014/jmb.1210.10053 |
| 4 | Inhibition of Pseudomonas aeruginosa and Escherichia coli O157:H7 Biofilm Formation by Plant Metabolite ε-Viniferin | Hyun Seob Cho, Jin-Hyung Lee, Shi Yong Ryu, Sang Woo Joo, Moo Hwan Cho, and Jintae Lee | Journal of Agricultural and Food Chemistry2013, 61(29), 7120-7126 | 2013 | https://doi.org/10.1021/jf4009313 |
| 5 | Biochemical characterization and evaluation of potent inhibitors of the Pseudomonas aeruginosa PA01 acetohydroxyacid synthase | June-Haeng Cho, Mi-Young Lee, Irshad Ahmed Baig, Na-Reum Ha, Joungmok Kim, Moon-Young Yoon | Biochimie2013, 1-11 | 2013 | https://doi.org/10.1016/j.biochi.2013.03.007 |
| 6 | Discovery of Novel Scaffolds for Rho Kinase 2 Inhibitor Through TRFRET- Based High Throughput Screening Assay | Kwang-Seok Oh, Jihye Mun, Jae Eun Cho, Sunghou Lee, Kyu Yang Yi, Chae Jo Lim, Jin Soo Lee, Whui Jung Park and Byung Ho Lee | Combinatorial Chemistry & High Throughput Screening2013, 16(1), 37-46 | 2013 | https://doi.org/10.2174/1386207311316010006 |
| 7 | Inhibition of influenza virus internalization by (-)-epigallocatechin-3-gallate | Meehyein Kim, So-Yeon Kim, Hye Won Lee, Jin Soo Shin, Pilho Kim, Young-Sik Jung, Hyeong-Seop Jeong, Jae-Kyung Hyun, Chong-Kyo Lee | Antiviral Research2013, 100, 460-472 | 2013 | https://doi.org/10.1016/j.antiviral.2013.08.002 |
| 8 | New Natural Herbicide Candidate for Sicyon angulatus Control | New Natural Herbicide Candidate for Sicyon angulatus Control | INTECH2013, chapter 12 | 2013 | https://doi.org/10.5772/54964 |
| 9 | Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors | Sung Yun Cho, Byung Ho Lee, Heejung Jung, Chang Soo Yun, Jae Du Ha, Hyoung Rae Kim, Chong Hak Chae, Jeong Hyun Lee, Ho Won Seo, Kwang-Seok Oh | Journal of Agricultural and Food Chemistry2013, 23(24), 6711-6716 | 2013 | https://doi.org/10.1016/j.bmcl.2013.10.036 |
| 10 | In silico identification of poly(ADP-ribose)polymerase-1 inhibitors and their chemosensitizing effects against cisplatin-resistant human gastric cancer cells | Tuong Vy Thi Le, Jee Hee Suh, Nakjeong Kim, Hyun-Ju Park | Bioorganic & Medicinal Chemistry Letters2013, 23(9), 2642-2646 | 2013 | https://doi.org/10.1016/j.bmcl.2013.02.094 |
| 11 | Efficient synthesis of 3H,3’H-spiro[benzofuran-2,1′-isobenzofuran]-3,3′-dione as novel skeletons specifically for influenza virus type B inhibition | Yashwardhan Malpani, Raghavendra Achary, So Yeon Kim, Hee Chun Jeong, Pilho Kim, Soo Bong Han, Meehyein Kim,, Chong-Kyo Lee, Jae Nyoung Kim, Young-Sik Jung | European Journal of Medicinal Chemistry2013, 62, 534-544 | 2013 | https://doi.org/10.1016/j.ejmech.2013.01.015 |
2012
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | Characterization of DDRI-18 (3,3′-(1H,3′H-5,5′-bibenzo[d]imidazole-2,2′-diyl)dianiline), a novel small molecule inhibitor modulating the DNA damage response | DW Jun, YS Jeong, HJ Kim, K-C Jeong, S Kim, C-H Lee | British Journal of Pharmacology2012, 167(1), 141-150 | 2012 | https://doi.org/10.1111/j.1476-5381.2012.01977.x |
| 2 | Proteolytic assay-based screening identifies a potent inhibitor of anthrax lethal factor | Hae-Chul Park, So-Ra Sung, Su Min Lim, Jong-Sun Lee, Sung-Kun Kim, Moon-Young Yoon | Microbial Pathogenesis2012, 53, 109-112 | 2012 | https://doi.org/10.1016/j.micpath.2012.04.004 |
| 3 | Identification and characterization of triamcinolone acetonide, a microglial-activation inhibitor | Jinpyo Hong, Bo-Kyong Kim, Hyoungsub Lim, Soojin Lee, Sung Joong Lee | Immunopharmacology and Immunotoxicology2012, 34(6), 912-918 | 2012 | https://doi.org/10.3109/08923973.2012.671332 |
| 4 | Plumbagin as a new natural herbicide candidate for Sicyon angulatus control agent with the target 8-amino-7-oxononanoate synthase | Jung-Sup Choi, No-Joong Park, Hee-Kyung Lim, Young-Kwan Ko, Young-Sup Kim, Shi-Yong Ryu, In-Taek Hwang | Pesticide Biochemistry and Physiology2012, 103, 166-172 | 2012 | https://doi.org/10.1016/j.pestbp.2012.04.007 |
| 5 | Inhibitory Effect of 4-Aryl 2-Substituted Aniline-thiazole Analogs on Growth of Human Prostate Cancer LNCap Cells | Seung-hwa Baek, Nakjeong Kim, Seong Hwan Kim, Kwang Hwa Park, Kyung-Chae Jeong, Bae Keun Park and Nam Sook Kang | Bulletin of the Korean Chemical Society2012, 33(1), 111-114 | 2012 | https://doi.org/10.5012/bkcs.2012.33.1.111 |
| 6 | A compound(DW1182v) protecting high glucose/palmitate-induced glucolipotoxicity to INS-1 beta cells preserves islet integrity and improves hyperglycemia in obese db/db mouse | Soo-Jin Lee, Sung-E Choi, Yun Cheong Hwang, Ik-Rak Jung, Sang-A Yi, Jong Gab Jung, Jin-Mo Ku, Kwiwan Jeoung, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Kwan-Woo Lee, Yup Kang | European Journal of Pharmacology2012, 696(1-3), 187-193 | 2012 | https://doi.org/10.1016/j.ejphar.2012.09.023 |
| 7 | Identification of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one derivatives as inhibitors of the phosphatase SerB653 in Porphyromonas gingivalis, implicated in periodontitis | Suk-Kyeong Jung, Youngkyung Ko, Keum Ran Yu, Ju Hee Kim, Joo-Youn Lee, Chong Hak Chae, Suk Ji, Chang Hyen Kim, Hyeon Kyu Lee, Eun Bok Choi, Bo Yeon Kim, Raymond L. Erikson, Sang J. Chung, Seung Jun Kim | Bioorganic and Medicinal Chemistry Letters2012, 22(5), 2084-2088 | 2012 | https://doi.org/10.1016/j.bmcl.2012.01.011 |
| 8 | Identification of novel mPGES-1 inhibitors through screening of a chemical library | Sung-Jun Park, Seong-Gu Han, Hafiz Muhammad Ahsan, Kijae Lee, Jae Yeol Lee, Ji-Sun Shin, Kyung-Tae Lee, Nam-Suk Kang, Yeon Gyu Yu | Bioorganic & Medicinal Chemistry Letters2012, 22, 7335-7339 | 2012 | https://doi.org/10.1016/j.bmcl.2012.10.085 |
| 9 | Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus | Suresh Thareja, Saurabh Aggarwal, T. R. Bhardwaj, Manoj Kumar | Medicinal Research Reviews2012, 32(3), 459-517 | 2012 | https://doi.org/10.1002/med.20219 |
| 10 | Structure-Activity Relationships and Optimization of 3,5-Dichloropyridine Derivatives As Novel P2X7 Receptor Antagonists | Won-Gil Lee, So-Deok Lee, Joong-Heui Cho, Younghwan Jung, Jeong-hyun Kim, Tran T. Hien, Keon-Wook Kang, Hyojin Ko, and Yong-Chul Kim | Journal of Medicinal Chemistry2012, 55, 3687-3698 | 2012 | https://doi.org/10.1021/jm2012326 |
| 11 | An In Vivo C. elegans Model System for Screening EGFR-Inhibiting Anti-Cancer Drugs | Young-Ki Bae, Jee Young Sung, Yong-Nyun Kim, Sunshin Kim, Kyeong Man Hong, Heung Tae Kim, Min Sung Choi, Jae Young Kwon, Jaegal Shim | PLoS ONE2012, 7(9), e42441 | 2012 | https://doi.org/10.1371/journal.pone.0042441 |
2011
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer | Akira Ooki, Keishi Yamashita, Shiro Kikuchi, Shinichi Sakuramoto, Natsuya Katada, Mina Waraya, Hiroshi Kawamata, Hiroshi Nishimiya, Kazunori Nakamura and Masahiko Watanabe | BMC Cancer2011, 11, 122 | 2011 | https://doi.org/10.1186/1471-2407-11-122 |
| 2 | High-Throughput Methods in Identification of Protein Tyrosine Phosphatase Inhibitors and Activators | Elina Mattila and Johanna Ivaska | Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry – Anti-Cancer Agents)2011, 11(1), 141-150 | 2011 | https://doi.org/10.2174/187152011794941235 |
| 3 | Chemical compound 31002 stimulates cardiomyogenic differentiation of embryonic stem cells | Eun Kyoung Kim, Mi-Young Son, Youngkuk Kang, Chang-Hee Lee, Hae Rim Kim, Youngsuk Won, Wonkee Yoon, Hyoung-Chin Kim, and Ki-Hoan Nam | Lab Anim Res2011, 27(3), 205-212 | 2011 | https://doi.org/10.5625/lar.2011.27.3.205 |
| 4 | Development and Comparison of Whole-Cell Assay Systems for Quorum-Sensing Inhibitors Based on TraR, LasR, and QscR | Hai-Bo Liu, Jung Sun Kim and Sunghoon Park | Journal of Biomolecular Screening2011, 16(9), 986-994 | 2011 | https://doi.org/10.1177/1087057111416656 |
| 5 | Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery | Hyun Uk Kim, Soo Young Kim, Haeyoung Jeong, Tae Yong Kim, Jae Jong Kim, Hyon E Choy, Kyu Yang Yi, Joon Haeng Rhee, Sang Yup Lee | Molecular Systems Biology2011, 460, 1-15 | 2011 | https://doi.org/10.1038/msb.2010.115 |
| 6 | Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging | Jae Hong Lee, Ju-Hoon So, Jong Hyun Jeon, Eun Bok Choi, Yu-Ri Lee, Young-Tae Chang, Cheol-Hee Kim, Myung Ae Bae and Jin Hee Ahn | Chemical Communications2011, 47(26), 7500-7502 | 2011 | https://doi.org/10.1039/C1CC11253H |
| 7 | Selective Killing of Bacterial Persisters by a Single Chemical Compound without Affecting Normal Antibiotic-Sensitive Cells | Jun-Seob Kim, Paul Heo, Tae-Jun Yang, Ki-Sing Lee, Da-Hyeong Cho, Bum Tae Kim, Ji-Hee Suh, Hee-Jong Lim, Dongwoo Shin, Sung-Koo Kim, and Dae-Hyuk Kweon | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY2011, 55(11), 5380-5383 | 2011 | https://doi.org/10.1128/AAC.00708-11 |
| 8 | 4-Chlorotetrazolo[1,5-a]quinoxaline inhibits activation of Syk kinase to suppress mast cells in vitro and mast cell-mediated passive cutaneous anaphylaxis in mice | Kui Lea Park, Na Young Ko, Jun Ho Lee, Do Kyun Kim, Hyuk Soon Kim, A-Ram Kim, Erk Her, Bokyung Kim, Hyung Sik Kim, Eun-Yi Moon, Young Mi Kim, Hang-Rae Kim, Wahn Soo Choi | Toxicology and Applied Pharmacology2011, 257, 235-241 | 2011 | https://doi.org/10.1016/j.taap.2011.09.009 |
| 9 | Novel PPARgamma partial agonists with weak activity and no cytotoxicity; identified by a simple PPARgamma ligand screening system | Min-Chul Cho, Dong-Hun Lee, Eun Jin Kim, Jee-young Lee, Jeong-Woo Kang, Jong Hwan Song, Youhoon Chong, Yangmi Kim, Jin-Tae Hong, Do-Young Yoon | Molecular and Cellular Biochemistry2011, 358, 75-83 | 2011 | https://doi.org/10.1007/s11010-011-0923-1 |
| 10 | Development of a High-Content Screening Method for Chemicals Modulating DNA Damage Response | Sunshin Kim, Dong Hwa Jun, Hye Jin Kim, Kyung-Chae Jeong, Chang-Hun Lee | Journal of Biomolecular Screening2011, 16(2), 259-265 | 2011 | https://doi.org/10.1177/1087057110392993 |
| 11 | KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to the hsp70 Promoter | Young Ju Yoon, Joo Ae Kim, Ki Deok Shin, Dae-Seop Shin, Young Min Han, Yu Jin Lee, Jin Soo Lee, Byoung-Mog Kwon, and Dong Cho Han | The Journal of Biological Chemistry2011, 286(3), 1737-1747 | 2011 | https://doi.org/10.1074/jbc.M110.179440 |
2010 ~ 2006
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | Inhibitors of the Pseudomonas aeruginosa quorum-sensing regulator, QscR | Hai-Bo Liu, Joon-Hee Lee, Jung Sun Kim and Sunghoon Park | Biotechnology and Bioengineering2010, 106(1), 119-126 | 2010 | https://doi.org/10.1002/bit.22672 |
| 2 | Autophagonizer, a novel synthetic small molecule, induces autophagic cell death | In-Kwon Choi, Yoon Sun Cho, Hye Jin Jung, Ho Jeong Kwon | Biochemical and Biophysical Research Communications2010, 393, 849-854 | 2010 | https://doi.org/10.1016/j.bbrc.2010.02.097 |
| 3 | Anti-inflammatory effects of synthetic compound KT-14480 in lipopolysaccharide-stimulated microglia cells | Jiyeon Ock, Kyoungho Suk | Journal of Pharmacy and Pharmacology2010, 62(2), 279-285 | 2010 | https://doi.org/10.1211/jpp.62.02.0017 |
| 4 | A novel anti-neuroinflammatory pyridylimidazole compound KR-31360 | Jiyeon Ock, Sangseop Kim, Kyu-Yang Yi, Nak-Jung Kim, Hyung Soo Han, Je-Yoel Cho, Kyoungho Suk | Biochemical Pharmacology2010, 79, 596-609 | 2010 | https://doi.org/10.1016/j.bcp.2009.09.026 |
| 5 | Identification of KT-15073 as an Inhibitor of Lipopolysaccharide-Induced Microglial Activation | Jiyeon Ock, Su Hyung Hong, Kyoungho Suk | Biological and Pharmaceutical Bulletin2010, 33(3), 461-467 | 2010 | https://doi.org/10.1248/bpb.33.461 |
| 6 | Identification of an ABCB/P-glycoprotein-specific Inhibitor of Auxin Transport by Chemical Genomics | Jun-Young Kim, Sina Henrichs, Aurelien Bailly, Vincent Vincenzetti, Valpuri Sovero, Stefano Mancuso, Stephan Pollmann, Daehwang Kim, Markus Geisler,and Hong-Gil Nam | The Journal of Biological Chemistry2010, 285(30), 23309-23317 | 2010 | https://doi.org/10.1074/jbc.M110.105981 |
| 7 | Identification of gp96 as a Novel Target for Treatment of Autoimmune Disease in Mice | Jung Min Han, Nam Hoon Kwon, Jin Young Lee, Seung Jae Jeong, Hee Jung Jung, Hyeong Rae Kim, Zihai Li, Sunghoon Kim | PLoS ONE2010, 5(3), e9792 | 2010 | https://doi.org/10.1371/journal.pone.0009792 |
| 8 | Identification of Novel Scaffolds for IkB Kinase Beta Inhibitor via a High Throughput Screening TR-FRET Assay | Kwang-Seok Oh, Sunghou Lee, Joong Kwon Choi and Byung Ho Lee | Combinatorial Chemistry & High Throughput Screening2010, 13, 790-797 | 2010 | https://doi.org/10.2174/138620710792927367 |
| 9 | Small-molecule inhibitors of c-Myc transcriptional factor suppress proliferation and induce apoptosis of promyelocytic leukemia cell via cell cycle arrest | Kyung-Chae Jeong,Kyung-Ohk Ahn and Chul-Hak Yang | Molecular BioSystems2010, 6(8), 1503-1509 | 2010 | https://doi.org/10.1039/c002534h |
| 10 | Characterization of Acetohydroxyacid Synthesis I from Escherichia coli K-12 and Identification of Its Inhibitors | Pham Ngoc Chien, Ji-Young Moon, Jun-Haeng Cho, Soo-Jae Lee, Joon-Shik Park, Dong-Eun Kim, Yoonkyung Park, and Moon-Young Yoon | Biosci. Biotechnol. Biochem2010, 74(11), 2281-2286 | 2010 | https://chembank.org/%ed%99%9c%ec%9a%a9%eb%85%bc%eb%ac%b8/%E2%80%A2%20https://doi.org/10.1271/bbb.100496 |
| 11 | Discovery of cyclicsulfonamide derivatives as 11b-hydroxysteroid dehydrogenase 1 inhibitors | Se Hoan Kim, Ravirala Ramu, Sung Wook Kwon, Su-Hee Lee, Chi Hyun Kim, Seung Kyu Kang, Sang Dal Rhee, Myung Ae Bae, Sung Hoon Ahn, Duck Chan Ha, Hyae Gyeong Cheon, Ki Young Kim, Jin Hee Ahn | Bioorganic & Medicinal Chemistry Letters2010, 20, 1065-1069 | 2010 | https://doi.org/10.1016/j.bmcl.2009.12.035 |
| 12 | Individual and common inhibitors of coronavirus and picornavirus main proteases | Chih-Jung Kuo, Hun-Ge Liu, Yueh-Kuei Lo, Churl-Min Seong, Kee-In Lee, Young-Sik Jung, Po-Huang Liang | FEBS Letters2009, 583, 549-555 | 2009 | https://doi.org/10.1016/j.febslet.2008.12.059 |
| 13 | Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity | Da-Hye Kang, Kyu-Yeon Jun, Jin Pyo Lee, Chwang Siek Pak, Younghwa Na, and Youngjoo Kwon | Journal of Medicinal Chemistry2009, 52(9), 3093-3097 | 2009 | https://doi.org/10.1021/jm8014734 |
| 14 | Synthesis and structure?activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists | Ga Eun Lee, Ho-Sung Lee, So Deok Lee, Jung-Ho Kim, Won-Ki Kim, Yong-Chul Kim | Bioorganic & Medicinal Chemistry Letters2009, 19, 954-958 | 2009 | https://doi.org/10.1016/j.bmcl.2008.11.088 |
| 15 | Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening | Hendra Gunosewoyo, Mark J. Coster, Maxwell R. Bennett, Michael Kassiou | Bioorganic & Medicinal Chemistry2009, 17, 4861-4865 | 2009 | https://doi.org/10.1016/j.bmc.2009.05.083 |
| 16 | Modulation of Osteocalcin Expression by Purmorphamine Derivatives | Hye-Ryun Kim, So-Hee Jeong, Young-Sam Im, Sung Yun Cho, Joong-Kwon Choi, Hea Kyeong Shin, Yong-Min Kim, Jin-Ook Song, Seong-Ho Jeon and Joong-Kook Choi | GENES & GENOMICS2009, 31(3), 261-266 | 2009 | https://doi.org/10.1007/BF03191198 |
| 17 | Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells | Jiyeon Ock, Sangseop Kim, Kyoungho Suk | Pharmacological Research2009, 59(6), 414-422 | 2009 | https://doi.org/10.1016/j.phrs.2009.02.008 |
| 18 | Induction of neurogenesis in rat bone marrow mesenchymal stem cells using purine structure-based compounds | Mi Hee Cho, Jung Hwa Lee, Hyun Hee Ahn, Ju Young Lee, E Sle Kim, Yun Mi Kang, Byoung Hyun Min, Jae Ho Kim, Hai Bang Lee and Moon Suk Kim | Molecular BioSystems2009, 5, 609-611 | 2009 | https://doi.org/10.1039/B905598N |
| 19 | Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA | Min-Ju Chae, Hye Youn Sung, Eun-Hye Kim, Mira Lee, Hojoong Kwak, Chong Hak Chae, Sunwoo Kim and Woong-Yang Park | EXPERIMENTAL and MOLECULAR MEDICINE2009, 41(11), 824-831 | 2009 | https://doi.org/10.3858/emm.2009.41.11.088 |
| 20 | Identification of Osteogenic Purmorphamine Derivatives | Sung-Jin Lee; Hak-Kyo Lee; Sung Yun Cho; Joong-Kwon Choi; Hea Kyeong Shin; Eun-Jung Kwak; Mi-Ran Cho; Hye-Ryun Kim; Seung-Ryol Kim; Yong-Min Kim; Kyoung-Jin Park; Joong-Kook Choi | Molecules & Cells2008, 26(4), 380-386 | 2008 | http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&i=0578320080260040380&m=VIEW |
| 21 | Identification of the catalytic subunit of acetohydroxyacid synthase in Haemophilus influenzae and its potent inhibitors | Kyoung-Jae Choi, Kyoung Mi Noh, Dong-Eun Kim, Byung Hak Ha, Eunice Eunkyung Kim, Moon-Young Yoon | Archives of Biochemistry and Biophysics2007, 466, 24-30 | 2007 | https://doi.org/10.1016/j.abb.2007.07.011 |
| 22 | What’s new on CDC25 phosphatase inhibitors | Marie-Odile Contour-Galcera, Alban Sidhu, Gregoire Prevost, Dennis Bigg, Bernard Ducommun | Pharmacology & Therapeutics2007, 115, 1-12 | 2007 | https://doi.org/10.1016/j.pharmthera.2007.03.009 |
| 23 | [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs | Yong Joo Na, Heung Su Baek, Soo Mi Ahn, Hyun Jung Shin, Ih-Seop Chang, Jae Sung Hwang | Biochemical Pharmacology2007, 74, 780-786 | 2007 | https://doi.org/10.1016/j.bcp.2007.05.028 |
| 24 | Indenone Derivatives: A Novel Template for Peroxisome Proliferator-Activated Receptor γ (PPARγ) Agonists | Jin Hee Ahn, Mi Sik Shin, Sun Ho Jung, Seung Kyu Kang, Kwang Rok Kim, Sang Dal Rhee, Won Hoon Jung, Sung Don Yang, Seung Jun Kim, Joo Rang Woo, Jeong Hyung Lee, Hyae Gyeong Cheon and Sung Soo Kim | Journal of Medicinal Chemistry2006, 49, 4781-4784 | 2006 | https://doi.org/10.1021/jm060389m |
| 25 | Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors | Jin Hee Ahn, Seung Jun Kim, Woul Seong Park, Sung Yun Cho, Jae Du Ha, Sung Soo Kim, Seung Kyu Kang, Dae Gwin Jeong, Suk-Kyeong Jung, Sang-Hyeup Lee, Hwan Mook Kim, Song Kyu Park, Ki Ho Lee, Chang Woo Lee, Seong Eon Ryu and Joong-Kwon Choi | Bioorganic & Medicinal Chemistry Letters2006, 16, 2996-2999 | 2006 | https://doi.org/10.1016/j.bmcl.2006.02.060 |
| 26 | Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt | Jong Hee Ko, Seung Woo Yeon, Jung Su Ryu, Tae-Yong Kim, Eun-Ha Song, Hea-Jung You, Rae-Eun Park and Chung-Kyu Ryu | Bioorganic & Medicinal Chemistry Letters2006, 16, 6001-6005 | 2006 | https://doi.org/10.1016/j.bmcl.2006.08.120 |
| 27 | PTP-1B inhibitors: Cyclopenta[d][1,2]-oxazine derivatives | Sung Yun Cho, Ji Yoen Baek, Sang Sub Han, Seung Kyu Kang, Jae Du Ha, Jin Hee Ahn, Jae Don Lee, Kwang Rok Kim, Hyae Gyeong Cheon, Sang Dal Rhee, Sung Don Yang, Gyu Hwan Yon, Chwang Siek Pak and Joong-Kwon Choi | Bioorganic & Medicinal Chemistry Letters2006, 16, 499-502 | 2006 | https://doi.org/10.1016/j.bmcl.2005.10.062 |
| 28 | Development of a time-resolved fluorometric assay for the high throughput screening of melanin concentrating hormone receptor antagonists | Sunghou Lee, Gun-Do Kim, Woo-Kyu Park, Heeyeong Cho, Byung Ho Lee, Sung-eun Yoo, Jae Yang Kong | Journal of Pharmacological and Toxicological Methods2006, 53, 242-247 | 2006 | https://doi.org/10.1016/j.vascn.2005.09.001 |
2005 ~
| # | Title | Author(s) | Journal | Year | Link |
|---|---|---|---|---|---|
| 1 | Inhibition of dipeptidyl peptidase IV by novel inhibitors with pyrazolidine scaffold | Hyae Gyeong Cheon, Sung-Soo Kim, Kwang-Rok Kim, Sang-Dal Rhee, Sung-Don Yang, Jin Hee Ahn, Sung-Dae Park, Jae Mok Lee, Won Hoon Jung, Hye Sook Lee, Hee Youn Kim | Biochemical Pharmacology2005, 70, 22-29 | 2005 | https://doi.org/10.1016/j.bcp.2005.04.004 |
| 2 | Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors | Jin Hee Ahn, Jin Ah Kim, Hye-Min Kim, Hyuk-Man Kwon, Sun-Chul Huh, Sang Dal Rhee, Kwang Rok Kim, Sung-Don Yang, Sung-Dae Park ,Jae Mok Lee, Sung Soo Kim and Hyae Gyeong Cheon | Bioorganic & Medicinal Chemistry Letters2005, 15, 1337-1340 | 2005 | https://doi.org/10.1016/j.bmcl.2005.01.020 |
| 3 | Pyrazolidine Derivatives with Heteroaryl Urea as Dipeptidyl Peptidase IV Inhibitors | Jin Hee AHN, Sun Ho JUNG, Jin Ah KIM, Seog Beom SONG, Soon Ji KWON, Kwang Rok KIM, Sang Dal RHEE, Sung-Dae PARK, Jae Mok LEE, Sung Soo KIM, and Hyae Gyeong CHEON | Chem. Pharm. Bull2005, 53(8), 1048-1050 | 2005 | https://doi.org/10.1248/cpb.53.1048 |
| 4 | Blocking Tumor Cell Migration and Invasion with Biphenyl Isoxazole Derivative KRIBB3, a Synthetic Molecule That Inhibits Hsp27 Phosphorylation | Ki Deok Shin, Mi-Young Lee, Dae-Seop Shin, Sangku Lee, Kwang-Hee Son, Sukhoon Koh, Young-Ki Paik, Byoung-Mog Kwon, and Dong Cho Han | The Journal of Biological Chemistry2005, 280(50), 41439-41448 | 2005 | https://doi.org/10.1074/jbc.M507209200 |
| 5 | EK-6136 (3-methyl-4-(O-methyl-oximino)-1-phenylpyrazolin-5-one): A novel Cdc25B inhibitor with antiproliferative activity | Kim, Kwang-Rok; Kwon, Ju-Lee; Kim, Ji-Sun; No, Zaesung; Kim, Hyoung Rae; Cheon, Hyae Gyeong | European Journal of Pharmacology2005, 528(1-3), 37-42 | 2005 | https://doi.org/10.1016/j.ejphar.2005.10.027 |
| 6 | EK-6136 (3-methyl-4-(O-methyl-oximino)-1-phenylpyrazolin-5-one): A novel Cdc25B inhibitor with antiproliferative activity | Kwang-Rok Kim, Ju-Lee Kwon, Ji-Sun Kim, Zaesung No, Hyoung Rae Kim, Hyae Gyeong Cheon | European Journal of Pharmacology2005, 528, 37-42 | 2005 | https://doi.org/10.1016/j.ejphar.2005.10.027 |
| 7 | KR-62436, 6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile, is a novel dipeptidyl peptidase-IV (DPP-IV) inhibitor with anti-hyperglycemic activity | Kwang-Rok Kim, Sang-Dal Rhee, Hee Youn Kim, Won Hoon Jung, Sung-Don Yang, Sung Soo Kim, Jin Hee Ahn, Hyae Gyeong Cheon | European Journal of Pharmacology2005, 518, 63-70 | 2005 | https://doi.org/10.1016/j.ejphar.2005.05.030 |
| 8 | (E)-Phenyl- and -heteroaryl-substituted O-benzoyl- (or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors | Tae-Sook Jeong, Mi Jeong Kim, Hana Yu, Kyung Soon Kim, Joong-Kwon Choi, Sung-Soo Kim and Woo Song Lee | Bioorganic & Medicinal Chemistry Letters2005, 15, 1525-1527 | 2005 | https://doi.org/10.1016/j.bmcl.2004.11.063 |
| 9 | Position of Pro and Ser near Glu7.32 in the Extracellular Loop 3 of Mammalian and Nonmammalian Gonadotropin-Releasing Hormone (GnRH) Receptors Is a Critical Determinant for Differential Ligand Selectivity for Mammalian GnRH and Chicken GnRH-II | CHENGBING WANG, OIM YUN, KAUSHIK MAITI, DA YOUNG OH, KYEONG KYU KIM, CHONG HAK CHAE, CHANG JUN LEE, JAE YOUNG SEONG, AND HYUK BANG KWON | Molecular Endocrinology2004, 18(1), 105-116 | 2004 | https://doi.org/10.1210/me.2003-0101 |
| 10 | Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent | Cheon, Hyae Gyeong; Kim, Sun-Mee; Yang, Sung-Don; Ha, Jae Du; Choi, Joong-Kwon | European Journal of Pharmacology2004, 485(1-3), 333-340 | 2004 | https://doi.org/10.1016/j.ejphar.2003.11.070 |
| 11 | Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent | Hyae Gyeong Cheon, Sun-Mee Kim, Sung-Don Yang, Jae Du Ha, Joong-Kwon Choi | European Journal of Pharmacology2004, 485, 333- 339 | 2004 | https://doi.org/10.1016/j.ejphar.2003.11.070 |
| 12 | Lead discovery of quinoxalinediones as an inhibitor of dipeptidyl peptidase-IV (DPP-IV) by high-throughput screening | Hyae-Gyeong Cheon, Chul-Min Lee, Beom-Tae Kim and Ki-Jun Hwang | Bioorganic & Medicinal Chemistry Letters2004, 14, 2661-2664 | 2004 | https://doi.org/10.1016/j.bmcl.2004.02.065 |
| 13 | Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents | Jin Hee Ahn, Hye-Min Kim, Sun Ho Jung, Seung Kyu Kang, Kwang Rok Kim, Sang Dal Rhee, Sung-Don Yang, Hyae Gyeong Cheon and Sung Soo Kim | Bioorganic & Medicinal Chemistry Letters2004, 14, 4461-4465 | 2004 | https://doi.org/10.1016/j.bmcl.2004.06.046 |
| 14 | Protein Tyrosine Phosphatase 1B Inhibitors: Catechols | Jin Hee Ahn, Sung Yun Cho, Jae Du Ha, Seung Kyu Kang, Sun Ho Jung, Hye-Min Kim, Sung Soo Kim, Kwang Rok Kim, Hyae Gyeong Cheon, Sung-Don Yang, and Joong-Kwon Choi | Bulletin of the Korean Chemical Society2003, 24(10), 1505-1508 | 2003 | https://doi.org/10.5012/bkcs.2003.24.10.1505 |
| 15 | Protein Tyrosine Phosphatase 1B Inhibitors: Heterocyclic Carboxylic Acids | Sung Yun Cho, Jin Hee Ahn, Jae Du Ha, Seung Kyu Kang, Ji Yoen Baek, Sang Sub Han, Eun Young Shin, Sung Soo Kim, Kwang Rok Kim, Hyae Gyeong Cheon, and Joong-Kwon Choi | Bulletin of the Korean Chemical Society2003, 24(10), 1455-1464 | 2003 | https://doi.org/10.5012/bkcs.2003.24.10.1455 |
| 16 | Design, Syntheses and Biological Evaluations of Nonpeptidic Caspase 3 Inhibitors | Eun-sook Kim, Sung-eun Yoo, Kyu Yang Yi, Sunkyung Lee, Jae-sung Noh, Yong-Sam Jung, Eunhee Kim, and Nakcheol Jeong | Bulletin of the Korean Chemical Society2002, 23(7), 1003-1110 | 2002 | https://doi.org/10.5012/bkcs.2002.23.7.1003 |
| 17 | Synthesis and PTP1B Inhibition of 1,2-Naphthoquinone Derivatives as Potent Anti-Diabetic Agents | Jin Hee Ahn,y Sung Yun Cho,y Jae Du Ha,y So Young Chu, Sun Ho Jung, Yoon Sung Jung, Ji Yoen Baek, In Kyung Choi, Eun Young Shin, Seung Kyu Kang, Sung Soo Kim, Hyae Gyeong Cheon, Sung-Don Yang and Joong-Kwon Choi | Bioorganic & Medicinal Chemistry Letters2002, 12, 1941-1946 | 2002 | https://doi.org/10.1016/S0960-894X(02)00331-1 |