연구동향

Benzothiazole scaffold as novel HCV inhibitor

작성자
관리자
작성일
2016-01-29 09:47
조회
2286
The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor

(출처) Chemical Communications, 2016, ASAP. DOI: 10.1039/c5cc10594c

 

A novel anti-HCV benzothiazole scaffold was discovered by phenotypic screening of in house chemical library.

Further target characterization and structural optimization studies revealed that the benzothiazole-disulfoamide derivatives were potent anti-HCV molecules with good selectivity and acted by targeting NS5A.?

 

DOI: 10.1039/c5cc10594c

 

링크:http://pubs.rsc.org/en/content/articlelanding/2016/cc/c5cc10594c